Unconventional myosin-XV (Myo15a) is a 2306-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9QZZ4.
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The mean pLDDT of this model is 70.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 12% |
| 70 to 90 | Confident: backbone generally right | 57% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Required for the arrangement of stereocilia in mature hair bundles
Interacts with the third PDZ domain of WHRN which is necessary for localization of WHRN to stereocilium tips. Interacts with FASLG (By similarity). Interacts with EPS8
Cell projection, stereocilium, Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6Y38 | X-ray | 1.7 Å | C/D=3499-3511 |
| 6Y9N | X-ray | 1.93 Å | B=3499-3511 |
| 7R91 | EM | 2.83 Å | D=1205-1889 |
| 7UDT | EM | 3.17 Å | D=1205-1923 |
| 7RB8 | EM | 3.63 Å | D=1205-1889 |
| 7RB9 | EM | 3.76 Å | D=1205-1889 |
| 7UDU | EM | 4.15 Å | D=1205-1923 |
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