Phosphatidylinositol 4-kinase beta (PI4KB) is a 816-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9UBF8.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 71.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 47% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 32% |
What pLDDT means and how to read it
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) (PubMed:10559940, PubMed:11277933, PubMed:12749687, PubMed:9405935). May play an important role in the inner ear development
Interacts with ARF1 and ARF3 in the Golgi complex, but not with ARF4, ARF5 or ARF6 (PubMed:17555535). Interacts with NCS1/FREQ in a calcium-independent manner. Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner; this interaction competes with NCS1/FREQ binding (By similarity). Interacts with ACBD3 (PubMed:22124328, PubMed:22258260, PubMed:23572552, PubMed:27009356,…
Endomembrane system, Mitochondrion outer membrane, Rough endoplasmic reticulum membrane, Golgi apparatus, Golgi apparatus membrane, Cytoplasm, perinuclear region
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8Q6F | X-ray | 1.51 Å | A=291-816 |
| 8Q6G | X-ray | 1.54 Å | A=291-816 |
| 8Q6H | X-ray | 1.94 Å | A=291-816 |
| 5NAS | X-ray | 2.08 Å | C/D=289-297 |
| 5LX2 | X-ray | 2.58 Å | B=292-297 |
| 5C46 | X-ray | 2.65 Å | E=121-799 |
| 6GL3 | X-ray | 2.77 Å | A/B=317-428, A/B=532-798 |
| 4D0L | X-ray | 2.94 Å | A/C/E=121-799 |
| 8VOF | X-ray | 3.0 Å | A=121-799 |
| 5C4G | X-ray | 3.2 Å | E=121-799 |
| 5EUQ | X-ray | 3.2 Å | E=121-248, E=523-799 |
| 5FBR | X-ray | 3.28 Å | A=128-799 |
| 5FBV | X-ray | 3.29 Å | A=128-799 |
| 4WAE | X-ray | 3.32 Å | A=128-799 |
| 5FBL | X-ray | 3.37 Å | A=128-799 |
| 4WAG | X-ray | 3.41 Å | A=128-799 |
| 5FBW | X-ray | 3.49 Å | A=128-799 |
| 5FBQ | X-ray | 3.79 Å | A=128-799 |
| 4D0M | X-ray | 6.0 Å | A/C/G/I/M/O/Q/S/W/Y/c/g=121-799 |
| 2N73 | NMR | B=1-68 |
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