Protein DBF4 homolog A (DBF4) is a 674-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9UBU7.
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The mean pLDDT of this model is 54.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 23% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 63% |
What pLDDT means and how to read it
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle
Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4A or DBF4B. Such complexes are stable upon replication stress. Interacts with MEN1, MCM2, ORC2, ORC4 and ORC6. Interacts (via IBM motifs) with PSIP1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (PubMed:29997176)
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6YA6 | X-ray | 1.44 Å | B=210-350 |
| 6YA7 | X-ray | 1.67 Å | B=210-350 |
| 6YA8 | X-ray | 1.79 Å | B=210-350 |
| 4F9C | X-ray | 2.08 Å | B=210-350 |
| 4F9A | X-ray | 2.17 Å | B/D=210-350 |
| 4F99 | X-ray | 2.33 Å | B=210-350 |
| 4F9B | X-ray | 2.5 Å | B/D=210-350 |
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