Neuronal acetylcholine receptor subunit alpha-9 (CHRNA9) is a 479-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9UGM1.
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The mean pLDDT of this model is 80.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 46% |
| 70 to 90 | Confident: backbone generally right | 32% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:11752216, PubMed:18723036, PubMed:25282151). Forms either homopentamers or heteropentamers with CHRNA10. Expressed in the…
Forms homo- or heteropentameric channels in conjunction with CHRNA10 (PubMed:11752216). The native outer hair cell receptor is composed of CHRNA9:CHRNA10 heterooligomers. Found in the stoichiometric form (CHRNA9)2:(CHRNA10)3 (By similarity)
Synaptic cell membrane, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4UXU | X-ray | 1.71 Å | A/B=26-237 |
| 4D01 | X-ray | 1.8 Å | A=26-237 |
| 6HY7 | X-ray | 2.26 Å | A=26-237 |
| 4UY2 | X-ray | 2.7 Å | A/B=26-237 |
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