Death-associated protein kinase 2 (DAPK2) is a 370-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9UIK4.
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The mean pLDDT of this model is 86.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 75% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421)
Homodimer in its autoinhibited state. Active as monomer (By similarity). Isoform 2 but not isoform 1 can interact with ATF4. Interacts with 14-3-3 proteins YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN; the interaction requires DAPK2 phosphorylation at Thr-369 and suppresses DAPK2 kinase activity and DAPK2-induced apoptosis (PubMed:26047703)
Cytoplasm, Cytoplasmic vesicle, autophagosome lumen
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2A2A | X-ray | 1.47 Å | A/B/C/D=11-330 |
| 1ZUZ | X-ray | 1.91 Å | B=312-330 |
| 1WRZ | X-ray | 2.0 Å | B=312-330 |
| 7A6Y | X-ray | 2.5 Å | J/K/L/M=364-370 |
| 7A6R | X-ray | 2.7 Å | E/F/G/L=364-370 |
| 2CKE | X-ray | 2.8 Å | A/B/C/D=11-330 |
| 1ZWS | X-ray | 2.9 Å | A/B/C/D/E/F/G/H=11-297 |
| 6PAW | X-ray | 2.95 Å | A/B/E/F=12-330 |
| 2A27 | X-ray | 3.0 Å | A/B/C/D/E/F/G/H=11-330 |
| 1WMK | X-ray | 3.6 Å | A/B/C/D/E/F/G/H=11-330 |
| 1Z9X | X-ray | 3.93 Å | A/B/C=11-330 |
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