REST corepressor 1 (RCOR1) is a 485-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9UKL0.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 68.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 37% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 38% |
What pLDDT means and how to read it
Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a…
Interacts directly with GFI1 and GFI1B in a RCOR/GFI/KDM1A/HDAC complex. Interacts with INMS1 (By similarity). Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with REST. Interacts with the SMARCE1/BAF57, suggesting that the BHC complex…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5H6Q | X-ray | 2.53 Å | B=311-443 |
| 2IW5 | X-ray | 2.57 Å | B=289-485 |
| 5H6R | X-ray | 2.6 Å | B=311-443 |
| 5L3D | X-ray | 2.6 Å | B=4-485 |
| 6TUY | X-ray | 2.6 Å | B=1-485 |
| 8Q1G | X-ray | 2.6 Å | B=308-485 |
| 6KGM | X-ray | 2.62 Å | B=311-443 |
| 6KGN | X-ray | 2.62 Å | B=311-443 |
| 7CDC | X-ray | 2.64 Å | B=311-443 |
| 9DBP | X-ray | 2.66 Å | B=312-442 |
| 7CDE | X-ray | 2.68 Å | B=311-443 |
| 7CDF | X-ray | 2.68 Å | B=311-443 |
| 5X60 | X-ray | 2.69 Å | B=311-443 |
| 6KGK | X-ray | 2.7 Å | B=311-443 |
| 6KGL | X-ray | 2.7 Å | B=311-443 |
| 7ZRY | X-ray | 2.7 Å | B=308-485 |
| 2UXN | X-ray | 2.72 Å | B=289-485 |
| 8FRV | X-ray | 2.72 Å | B=308-443 |
| 2UXX | X-ray | 2.74 Å | B=289-485 |
| 8BOP | X-ray | 2.74 Å | B=308-443 |
Showing 20 of 102 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.