ALK tyrosine kinase receptor (ALK) is a 1620-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9UM73.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 68.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 20% |
| 70 to 90 | Confident: backbone generally right | 37% |
| 50 to 70 | Low: treat with caution | 15% |
| Below 50 | Very low: often disordered regions | 27% |
What pLDDT means and how to read it
Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:11121404, PubMed:11387242, PubMed:16317043, PubMed:17274988, PubMed:30061385, PubMed:34646012, PubMed:34819673). Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity). Following activation by ALKAL2 ligand at the cell surface, transduces an…
Homodimer; homodimerizes following heparin- and ligand-binding (PubMed:16317043, PubMed:25605972, PubMed:34646012, PubMed:34819673). Interacts with CBL, IRS1, PIK3R1 and PLCG1 (PubMed:15226403). Interacts with FRS2 and SHC1 (PubMed:15226403, PubMed:16878150, PubMed:17274988). Interacts with PTN and MDK (PubMed:11278720, PubMed:12122009)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7MZY | X-ray | 1.5 Å | A/B=673-986 |
| 4Z55 | X-ray | 1.55 Å | A=1072-1410 |
| 9GBE | X-ray | 1.58 Å | A=1069-1411 |
| 5A9U | X-ray | 1.6 Å | A=1093-1411 |
| 8ARJ | X-ray | 1.65 Å | A=1093-1411 |
| 4CLJ | X-ray | 1.66 Å | A=1093-1411 |
| 2YFX | X-ray | 1.7 Å | A=1093-1411 |
| 4ANL | X-ray | 1.7 Å | A=1093-1411 |
| 4FNX | X-ray | 1.7 Å | A=1084-1410 |
| 4FOC | X-ray | 1.7 Å | A=1058-1410 |
| 5AAC | X-ray | 1.7 Å | A=1093-1411 |
| 5FTQ | X-ray | 1.7 Å | A=1094-1407 |
| 4CMT | X-ray | 1.73 Å | A=1093-1411 |
| 5AAA | X-ray | 1.73 Å | A=1093-1411 |
| 3AOX | X-ray | 1.75 Å | A=1069-1411 |
| 4FNW | X-ray | 1.75 Å | A=1084-1410 |
| 4ANQ | X-ray | 1.76 Å | A=1093-1411 |
| 4CTB | X-ray | 1.79 Å | A=1093-1411 |
| 3L9P | X-ray | 1.8 Å | A=1072-1410 |
| 4CMU | X-ray | 1.8 Å | A=1093-1411 |
Showing 20 of 79 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.