5AAC: C1156Y Mutant Human Anaplastic Lymphoma Kinase

Structure of C1156Y Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib. Determined by X-ray diffraction at 1.7 Å resolution. Released 8 Jun 2016.

Method: X-ray diffraction
Resolution: 1.7 Å
Organism: HOMO SAPIENS
Chains: 1
Atoms: 2,590
Mol. weight: 37.42 kDa
Ligands: VGH
Released: 8 Jun 2016

Explore 5AAC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5AAC contains 21 α-helices and 12 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 21 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	1095-1098	4	1
β-strand	1101-1104	4	1
α-helix	1105-1107	3
β-strand	1110	1	2
α-helix	1113-1115	3
β-strand	1117-1121	5	2
β-strand	1130-1134	5	2
β-strand	1146-1151	6	2
α-helix	1158-1173	16
β-strand	1179	1	3
α-helix	1180-1181	2
β-strand	1182-1186	5	2
α-helix	1192	1
β-strand	1193-1197	5	2
β-strand	1202-1203	2	3
α-helix	1204-1210	7
α-helix	1223-1242	20
α-helix	1252-1254	3
β-strand	1255-1257	3	3
β-strand	1266-1268	3	3
α-helix	1272-1278	7
α-helix	1288-1290	3
α-helix	1293-1295	3
α-helix	1298-1303	6
α-helix	1308-1323	16
α-helix	1327-1328	2
α-helix	1335-1343	9
α-helix	1348-1351	4
α-helix	1356-1365	10
α-helix	1370-1372	3
α-helix	1376-1388	13
α-helix	1390-1393	4
α-helix	1395-1398	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Alk tyrosine kinase receptor	A	protein	327	HOMO SAPIENS	Q9UM73 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>5AAC_1 ALK TYROSINE KINASE RECEPTOR (chains A)
MAHHHHHHNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSP
LQVAVKTLPEVYSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDL
KSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGR
VAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFS
LGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIE
YCTQDPDVINTALPIEYGPLVEEEEKV

Ligands and cofactors

ID	Name	Formula	Copies
VGH	3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4…	C21 H22 Cl2 F N5 O	1

Primary citation

Resensitization to Crizotinib by the Lorlatinib Alk Resistance Mutation L1198F. Shaw, A.T., Friboulet, L., Leshchiner, I. et al. N Engl J Med (2016) 374:54. DOI 10.1056/NEJMOA1508887 · PubMed

Other PDB entries of the same protein (UniProt Q9UM73 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7MZY 1.5 Å, Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 673-986
4Z55 1.55 Å, Anaplastic lymphoma kinase catalytic domain complexed with pyrazolopyrimidine derivative…
9GBE 1.58 Å, Structure of Human Anaplastic Lymphoma Kinase (ALK) harboring the G1202R/L1196M Compound…
5A9U 1.6 Å, Structure of C1156Y Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922…
8ARJ 1.65 Å, Anaplastic Lymphoma Kinase with a novel carboline inhibitor
4CLJ 1.66 Å, Structure of L1196M Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922…
2YFX 1.7 Å, Structure of L1196M Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib
4ANL 1.7 Å, Structure of G1269A Mutant Anaplastic Lymphoma Kinase
4FNX 1.7 Å, Crystal structure of the apo R1275Q anaplastic lymphoma kinase catalytic domain
4FOC 1.7 Å, Crystal structure of human anaplastic lymphoma kinase in complex with…
5FTQ 1.7 Å, Crystal structure of the ALK kinase domain in complex with Cmpd 17
4CMT 1.73 Å, Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor…

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