Coiled-coil and C2 domain-containing protein 1-like (l(2)gd1) is a 816-residue protein from Drosophila melanogaster. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9VKJ9.
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The mean pLDDT of this model is 74.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 35% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
Phosphatidyl inositol monophosphate binding protein involved in endosomal protein sorting through regulation of the endosomal sorting required for transport (ESCRT) pathway (PubMed:17084357, PubMed:28564595, PubMed:33349255). Required for full activity of the ESCRT-III complex core component shrb/shrub, probably by preventing its inappropriate polymerization (PubMed:28564595, PubMed:33349255). Required, but not essential, for the efficient generation of intraluminal vesicles (ILVs) in multivesicular bodies (MVBs) (PubMed:33349255). Involved in a late stage of the endosomal pathway targeting transmembrane proteins of the plasma membrane for lysosomal degradation (PubMed:17084357,…
Interacts (via DM14 domains 1 and 3) with shrb; the interaction is direct and blocks access to the surface involved in shrb polymerization (PubMed:22389409, PubMed:27452459, PubMed:28564595). This interaction may be required for the ESCRT-III complex role in multivesicular body formation (PubMed:22389409)
Cytoplasm, Cytoplasm, cytosol, Apicolateral cell membrane, Cytoplasm, cell cortex, Endosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5VNY | X-ray | 1.1 Å | A=359-423 |
| 5VO5 | X-ray | 2.0 Å | A=359-423 |
| 6EI6 | X-ray | 2.46 Å | A/B=550-816 |
| 7ZSS | EM | 2.63 Å | D/P/h=359-423 |
| 7ZRV | EM | 2.8 Å | E/F=356-423 |
| 7ZSD | EM | 3.29 Å | P=359-423 |
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