DNA polymerase eta (POLH) is a 713-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9Y253.
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The mean pLDDT of this model is 76.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 61% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 29% |
What pLDDT means and how to read it
DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:16357261, PubMed:20388628, PubMed:24449906, PubMed:24553286, PubMed:38212351). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124,…
Interacts with REV1 (via C-terminal domain) (PubMed:22691049). Interacts with monoubiquitinated PCNA, but not unmodified PCNA (PubMed:15149598). Interacts with POLI; this interaction targets POLI to the replication machinery (PubMed:12606586). Interacts with PALB2 and BRCA2; the interactions are direct and are required to sustain the recruitment of POLH at blocked replication forks and to…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7M7N | X-ray | 1.31 Å | A=1-432 |
| 5KFZ | X-ray | 1.44 Å | A=1-432 |
| 5KFN | X-ray | 1.45 Å | A=1-432 |
| 5KFS | X-ray | 1.46 Å | A=1-432 |
| 7M7M | X-ray | 1.46 Å | A=1-432 |
| 7M7T | X-ray | 1.46 Å | A=1-432 |
| 7M84 | X-ray | 1.47 Å | A=1-432 |
| 7U7L | X-ray | 1.47 Å | A=1-432 |
| 4ECQ | X-ray | 1.5 Å | A=1-432 |
| 5KFC | X-ray | 1.5 Å | A=1-432 |
| 5KFA | X-ray | 1.51 Å | A=1-432 |
| 4ECV | X-ray | 1.52 Å | A=1-432 |
| 4ED8 | X-ray | 1.52 Å | A=1-432 |
| 5KFO | X-ray | 1.52 Å | A=1-432 |
| 5KFT | X-ray | 1.52 Å | A=1-432 |
| 5KFX | X-ray | 1.52 Å | A=1-432 |
| 7U74 | X-ray | 1.52 Å | A=1-432 |
| 8V7G | X-ray | 1.52 Å | A=1-432 |
| 7U72 | X-ray | 1.53 Å | A=1-432 |
| 7U7U | X-ray | 1.54 Å | A=1-432 |
Showing 20 of 241 experimental structures (best resolution first).
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