Tudor and KH domain-containing protein (TDRKH) is a 561-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9Y2W6.
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The mean pLDDT of this model is 74.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 48% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 26% |
What pLDDT means and how to read it
Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules
Interacts with (symmetrically methylated) PIWIL1, PIWIL2 and PIWIL4
Cytoplasm, Mitochondrion
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3FDR | X-ray | 1.75 Å | A=327-420 |
| 6B57 | X-ray | 1.93 Å | A/B=309-497 |
| 5J39 | X-ray | 1.95 Å | A/B=309-498 |
| 6PI7 | X-ray | 2.8 Å | A/D=305-525 |
| 2DIQ | NMR | A=329-425 |
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