Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) is a 329-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9Y5K5.
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The mean pLDDT of this model is 90.3 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 74% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1
Component of the 19S (PA700) regulatory complex of the 26S proteasome. Interacts with ADRM1 and NFRKB; in vitro ADRM1 and NFRKB compete for interaction with UCHL5. Component of the INO80 complex; specifically part of a complex module associated with N-terminus of INO80
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3RII | X-ray | 2.0 Å | A/B=1-228 |
| 3A7S | X-ray | 2.2 Å | A=1-228 |
| 3TB3 | X-ray | 2.3 Å | A/B=1-227 |
| 4UEL | X-ray | 2.3 Å | A=1-329 |
| 3RIS | X-ray | 2.4 Å | A/B/C/D=1-240 |
| 9E7K | X-ray | 2.41 Å | A=1-329 |
| 4UEM | X-ray | 2.82 Å | A=1-329 |
| 3IHR | X-ray | 2.95 Å | A=1-329 |
| 4WLP | X-ray | 3.1 Å | A=5-322 |
| 4UF6 | X-ray | 3.69 Å | A/D/G/J=1-329 |
| 4UF5 | X-ray | 3.7 Å | A=1-329 |
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