Suppressor of tumorigenicity 14 protein (ST14) is a 855-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9Y5Y6.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 80.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 34% |
| 70 to 90 | Confident: backbone generally right | 47% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (PubMed:10373424). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing (PubMed:18843291). Proteolytically cleaves and therefore activates TMPRSS13 (PubMed:28710277)
Interacts with CDCP1. May interact with TMEFF1. Interacts with iripin-3, a serine protease inhibitor from Ixodes ricinus saliva (PubMed:33732248). Interacts with iripin-1, a serine protease inhibitor from Ixodes ricinus saliva (PubMed:36756125)
Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3NCL | X-ray | 1.19 Å | A=615-855 |
| 3P8G | X-ray | 1.2 Å | A=615-855 |
| 8G1W | X-ray | 1.2 Å | A=615-855 |
| 1EAX | X-ray | 1.3 Å | A=615-855 |
| 8G1V | X-ray | 1.35 Å | A=615-855 |
| 4IS5 | X-ray | 1.48 Å | A=615-855 |
| 3NPS | X-ray | 1.5 Å | A=615-855 |
| 6T9T | X-ray | 1.69 Å | A=615-855 |
| 4JZ1 | X-ray | 1.9 Å | A=615-855 |
| 4O9V | X-ray | 1.9 Å | A=615-855, B=604-607 |
| 4R0I | X-ray | 1.9 Å | A=615-855 |
| 6N4T | X-ray | 1.95 Å | A=615-855 |
| 3P8F | X-ray | 2.0 Å | A=615-855 |
| 4JYT | X-ray | 2.0 Å | A=615-855 |
| 4JZI | X-ray | 2.0 Å | A=615-855 |
| 4ISO | X-ray | 2.01 Å | A=615-855 |
| 2GV6 | X-ray | 2.1 Å | A=615-855 |
| 3SO3 | X-ray | 2.1 Å | A=615-855 |
| 3BN9 | X-ray | 2.17 Å | A/B=615-855 |
| 2GV7 | X-ray | 2.2 Å | A=615-855 |
Showing 20 of 25 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.