Nuclear receptor coactivator 3 (NCOA3) is a 1424-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9Y6Q9.
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The mean pLDDT of this model is 48.2 (very low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 9% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 70% |
What pLDDT means and how to read it
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit
Present in a complex containing NCOA2, IKKA, IKKB, IKBKG and the histone acetyltransferase protein CREBBP (PubMed:11971985, PubMed:9346901). Found in a complex containing NCOA3, AR and MAK (PubMed:16951154). Interacts with ATAD2; the interaction is enhanced by estradiol (PubMed:17998543). Interacts with CARM1 (By similarity). Interacts with CASP8AP2 (PubMed:15698540). Interacts with ESR…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3L3X | X-ray | 1.55 Å | B=618-629 |
| 9HFW | X-ray | 1.7 Å | B=91-107 |
| 3L3Z | X-ray | 2.0 Å | B=735-746 |
| 6SQC | X-ray | 2.28 Å | B=1045-1091 |
| 1KBH | NMR | A=1045-1091 | |
| 6ES7 | NMR | A=1045-1086 |
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