Human RNase PNK bound to ATPyS ligand. Determined by electron microscopy at 3.6 Å resolution. Released 26 Aug 2026.
Explore 10RN in 3D Show helices and sheets RCSB PDB PDBe
10RN contains 52 α-helices and 78 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 48-58 | 11 | |
| α-helix | 65-76 | 12 | |
| α-helix | 89-103 | 15 | |
| α-helix | 109-127 | 19 | |
| α-helix | 152-158 | 7 | |
| α-helix | 166-183 | 18 | |
| α-helix | 622-632 | 11 | |
| β-strand | 639-640 | 2 | 1 |
| α-helix | 641-642 | 2 | |
| α-helix | 647-649 | 3 | |
| β-strand | 671-673 | 3 | 2 |
| β-strand | 680 | 1 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 116-117 | 2 | 4 |
| β-strand | 123-128 | 6 | 4 |
| β-strand | 134-138 | 5 | 5 |
| β-strand | 139-146 | 8 | 4 |
| β-strand | 148-151 | 4 | 6 |
| β-strand | 154-157 | 4 | 6 |
| α-helix | 161-162 | 2 | |
| β-strand | 163-166 | 4 | 4 |
| β-strand | 174-176 | 3 | 5 |
| α-helix | 188-200 | 13 | |
| α-helix | 208-213 | 6 | |
| β-strand | 220-225 | 6 | 4 |
| α-helix | 230-237 | 8 | |
| α-helix | 256-264 | 9 | |
| β-strand | 266-268 | 3 | 5 |
| α-helix | 281-288 | 8 | |
| β-strand | 301-304 | 4 | 7 |
| β-strand | 305 | 1 | 8 |
| α-helix | 312-323 | 12 | |
| β-strand | 330-332 | 3 | 9 |
| β-strand | 333-335 | 3 | 7 |
| β-strand | 347-350 | 4 | 10 |
| β-strand | 351-353 | 3 | 9 |
| β-strand | 370-373 | 4 | 10 |
| α-helix | 386-394 | 9 | |
| β-strand | 403-407 | 5 | 7 |
| α-helix | 414-423 | 10 | |
| β-strand | 430 | 1 | 7 |
| β-strand | 433 | 1 | 8 |
| α-helix | 447-451 | 5 | |
| β-strand | 454 | 1 | 11 |
| β-strand | 459 | 1 | 11 |
| β-strand | 497 | 1 | 7 |
| β-strand | 500 | 1 | 8 |
| α-helix | 512-528 | 17 | |
| α-helix | 529-531 | 3 | |
| α-helix | 542-544 | 3 | |
| β-strand | 548-549 | 2 | 1 |
| β-strand | 551 | 1 | 12 |
| α-helix | 552-554 | 3 | |
| β-strand | 556-557 | 2 | 2 |
| β-strand | 559 | 1 | 12 |
| α-helix | 566-571 | 6 | |
| β-strand | 577-578 | 2 | 12 |
| β-strand | 582 | 1 | 13 |
| β-strand | 595-597 | 3 | 2 |
| β-strand | 601 | 1 | 3 |
| β-strand | 604 | 1 | 13 |
| β-strand | 609-615 | 7 | 12 |
| β-strand | 620-624 | 5 | 12 |
| α-helix | 629-632 | 4 | |
| β-strand | 640 | 1 | 12 |
| α-helix | 647-651 | 5 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Ribosomal biogenesis protein LAS1L | A, D | protein | 777 | Homo sapiens | Q9Y4W2 (AlphaFold model) |
| Polynucleotide 5'-hydroxyl-kinase NOL9 | B, E | protein | 605 | Homo sapiens | Q5SY16 (AlphaFold model) |
>10RN_1 Ribosomal biogenesis protein LAS1L (chains A, D) MASWSHPQFEKGGGARGGSGGGSWSHPQFEKGFDYKDDDDKGTMSWESGAGPGLGSQGMD LVWSAWYGKCVKGKGSLPLSAHGIVVAWLSRAEWDQVTVYLFCDDHKLQRYALNRITVWR SRSGNELPLAVASTADLIRCKLLDVTGGLGTDELRLLYGMALVRFVNLISERKTKFAKVP LKCLAQEVNIPDWIVDLRHELTHKKMPHINDCRRGCYFVLDWLQKTYWCRQLENSLRETW ELEEFREGIEEEDQEEDKNIVVDDITEQKPEPQDDGKSTESDVKADGDSKGSEEVDSHCK KALSHKELYERARELLVSYEEEQFTVLEKFRYLPKAIKAWNNPSPRVECVLAELKGVTCE NREAVLDAFLDDGFLVPTFEQLAALQIEYEDGQTEVQRGEGTDPKSHKNVDLNDVLVPKP FSQFWQPLLRGLHSQNFTQALLERMLSELPALGISGIRPTYILRWTVELIVANTKTGRNA RRFSAGQWEARRGWRLFNCSASLDWPRMVESCLGSPCWASPQLLRIIFKAMGQGLPDEEQ EKLLRICSIYTQSGENSLVQEGSEASPIGKSPYTLDSLYWSVKPASSSFGSEAKAQQQEE QGSVNDVKEEEKEEKEVLPDQVEEEEENDDQEEEEEDEDDEDDEEEDRMEVGPFSTGQES PTAENARLLAQKRGALQGSAWQVSSEDVRWDTFPLGRMPGQTEDPAELMLENYDTMYLLD QPVLEQRLEPSTCKTDTLGLSCGVGSGNCSNSSSSNFEGLLWSQGQLHGLKTGLQLF
>10RN_2 Polynucleotide 5'-hydroxyl-kinase NOL9 (chains B, E) GGGGGTASSCHRPLLIPPVRPVGPGRALLLLPVEQGFTFSGICRVTCLYGQVQVFGFTIS QGQPAQDIFSVYTHSCLSIHALHYSQPEKSKKELKREARNLLKSHLNLDDRRWSMQNFSP QCSIVLLEHLKTATVNFITSYPGSSYIFVQESPTPQIKPEYLALRSVGIRREKKRKGLQL TESTLSALEELVNVSCEEVDGCPVILVCGSQDVGKSTFNRYLINHLLNSLPCVDYLECDL GQTEFTPPGCISLLNITEPVLGPPFTHLRTPQKMVYYGKPSCKNNYENYIDIVKYVFSAY KRESPLIVNTMGWVSDQGLLLLIDLIRLLSPSHVVQFRSDHSKYMPDLTPQYVDDMDGLY TKSKTKMRNRRFRLAAFADALEFADEEKESPVEFTGHKLIGVYTDFAFRITPRNRESHNK ILRDLSILSYLSQLQPPMPKPLSPLHSLTPYQVPFNAVALRITHSDVAPTHILYAVNASW VGLCKIQDDVRGYTNGPILLAQTPICDCLGFGICRGIDMEKRLYHILTPVPPEELRTVNC LLVGAIAIPHCVLKCQRGIEGTVPYVTTDYNFKLPGASEKIGAREPEEAHKEKPYRRPKF CRKMK
| ID | Name | Formula | Copies |
|---|---|---|---|
| MG | Magnesium ion | Mg | 2 |
| AGS | Phosphothiophosphoric acid-adenylate ester | C10 H16 N5 O12 P3 S | 2 |
Structural insights into RNA phosphorylation by the RNase PNK module of the human rixosome complex. Gordon, J., Seely, S.M., Wang, H. et al. Nucleic Acids Res (2026) 54. DOI 10.1093/nar/gkag826 · PubMed
Other PDB entries of the same protein (UniProt Q9Y4W2 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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