11IQ: Rabbit 80S with eEF2,eIF5A and SERBP1

Rabbit 80S with eEF2,eIF5A and SERBP1. Determined by electron microscopy at 2.4 Å resolution. Released 2 Sept 2026.

Method: Electron microscopy
Resolution: 2.4 Å
Organism: Oryctolagus cuniculus
Chains: 87
Atoms: 224,491
Mol. weight: 5454.26 kDa
Ligands: GDP, ZN
Released: 2 Sept 2026

Explore 11IQ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

11IQ contains 696 α-helices and 652 β-strands across 82 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 10: 10 helices, 13 β-strands

Element	Residues	Length	Sheet
α-helix	6-9	4
α-helix	15-16	2
β-strand	18	1	137
α-helix	26-29	4
β-strand	35-37	3	138
α-helix	43-45	3
β-strand	48-54	7	138
β-strand	58-61	4	137
α-helix	62-80	19
β-strand	85-89	5	138
β-strand	95-99	5	137
α-helix	119-120	2
β-strand	121-129	9	137
β-strand	134-140	7	138
α-helix	142-144	3
α-helix	145-156	12
β-strand	163-167	5	138
β-strand	170	1	139
β-strand	177	1	139
α-helix	181-186	6
β-strand	190-193	4	140
β-strand	196-199	4	140
α-helix	206-213	8

Chain 11: 7 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	11-13	3
β-strand	16-25	10	200
α-helix	31-44	14
β-strand	49-52	4	200
β-strand	57	1	201
β-strand	62	1	201
β-strand	67-74	8	200
α-helix	76-89	14
β-strand	93-95	3	202
α-helix	96-98	3
β-strand	99	1	200
β-strand	105-109	5	200
α-helix	112-115	4
β-strand	128-135	8	200
α-helix	139-142	4
α-helix	159-170	12
β-strand	173-175	3	202

Chain 13: 14 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	18-21	4
β-strand	22-24	3	102
α-helix	28-46	19
β-strand	55	1	103
α-helix	56-57	2
β-strand	58-60	3	104
α-helix	63-66	4
β-strand	70-72	3	104
β-strand	76	1	105
α-helix	78-84	7
α-helix	88-91	4
α-helix	92-94	3
β-strand	96	1	103
β-strand	98	1	105
β-strand	106	1	106
α-helix	107-123	17
β-strand	124-126	3	107
α-helix	127-128	2
α-helix	139-140	2
α-helix	141-146	6
β-strand	167	1	108
α-helix	168-170	3
α-helix	171-175	5
α-helix	178-210	33

Chain 14: 5 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	7-8	2	116
β-strand	11-15	5	117
β-strand	24-30	7	117
β-strand	35-40	6	117
β-strand	45-51	7	117
α-helix	52-54	3
β-strand	55-61	7	117
α-helix	70-80	11
α-helix	82-88	7
α-helix	90-102	13
α-helix	106-138	33

Chain 15: 13 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	3-11	9
α-helix	17-32	16
β-strand	36-39	4	128
α-helix	45-50	6
β-strand	59-67	9	128
α-helix	76-78	3
α-helix	84-86	3
α-helix	98-109	12
β-strand	114-123	10	128
β-strand	127-135	9	128
α-helix	140-143	4
α-helix	149-152	4
α-helix	154-156	3
α-helix	159-162	4
α-helix	166-171	6
α-helix	178-183	6
α-helix	188-195	8
β-strand	198-200	3	102

Chain 17: 11 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	11-13	3
β-strand	14-22	9	1
α-helix	26-36	11
β-strand	40	1	1
α-helix	41-52	12
α-helix	57	1
β-strand	58-59	2	2
β-strand	69	1	3
α-helix	71-76	6
β-strand	80	1	3
β-strand	81-82	2	2
α-helix	85-105	21
α-helix	109-111	3
β-strand	112-121	10	1
α-helix	122-124	3
β-strand	125	1	4
α-helix	126	1
β-strand	128-131	4	5
β-strand	135-138	4	5
β-strand	141	1	4
β-strand	144-152	9	1
α-helix	157-160	4
α-helix	172-182	11

Chain 19: 10 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	5-15	11
β-strand	22-24	3	20
α-helix	29-33	5
α-helix	38-47	10
β-strand	50-52	3	20
α-helix	53-57	5
α-helix	61-70	10
α-helix	78-80	3
α-helix	85-88	4
α-helix	91-111	21
α-helix	117-128	12
α-helix	135-180	46

Chain 20: 8 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	8-16	9	142
α-helix	17-18	2
α-helix	25-27	3
β-strand	28-34	7	142
α-helix	37-51	15
β-strand	59-66	8	142
β-strand	76-85	10	143
β-strand	90-99	10	143
α-helix	102-117	16
α-helix	121-123	3
β-strand	124-132	9	143
α-helix	134-136	3
α-helix	140-143	4
β-strand	151-152	2	116
β-strand	168	1	136
α-helix	171-173	3

74 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Large ribosomal subunit protein uL22	17	protein	183	Oryctolagus cuniculus	G1SCJ6 (AlphaFold model)
Small ribosomal subunit protein uS17	DD	protein	151	Oryctolagus cuniculus	G1TRM4 (AlphaFold model)
5.8S rRNA	58	RNA	156	Oryctolagus cuniculus
5S rRNA	5	RNA	120	Oryctolagus cuniculus
60S ribosomal protein L8	L8	protein	248	Oryctolagus cuniculus	G1TT27 (AlphaFold model)
60S ribosomal protein L3	L3	protein	394	Oryctolagus cuniculus	G1TL06 (AlphaFold model)
60S ribosomal protein L4	L4	protein	362	Oryctolagus cuniculus	A0A5F9DCT1
60S ribosomal protein L5	L5	protein	293	Oryctolagus cuniculus	P19949
60S ribosomal protein L6	L6	protein	291	Oryctolagus cuniculus	G1SKF7
60S ribosomal protein L7	L7	protein	253	Oryctolagus cuniculus
Large ribosomal subunit protein eL8	aa	protein	240	Oryctolagus cuniculus
Large ribosomal subunit protein eL13	13	protein	241	Oryctolagus cuniculus

75 more molecules are not listed.

Sequence of entity 1 (17), FASTA

>11IQ_1 Large ribosomal subunit protein uL22 (chains 17)
VRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLKKQCVPFR
RYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNK
APKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLM
ARE

Sequence of entity 2 (DD), FASTA

>11IQ_2 Small ribosomal subunit protein uS17 (chains DD)
DIQTERAYQKQPTIFQNKKRVLLGETGKEKLPRYYKNIGLGFKTPKEAIEGTYIDKKCPF
TGNVSIRGRILSGVVTKMKMQRTIVIRRDYLHYIRKYNRFEKRHKNMSVHLSPCFRDVQI
GDIVTVGECRPLSKTVRFNVLKVTKAAGTKK

Sequence of entity 3 (58), FASTA

>11IQ_3 5.8S rRNA (chains 58)
CGACUCUUAGCGGUGGAUCACUCGGCUCGUGCGUCGAUGAAGAACGCAGCUAGCUGCGAG
AAUUAAUGUGAAUUGCAGGACACAUUGAUCAUCGACACUUCGAACGCACUUGCGGCCCCG
GGUUCCUCCCGGGGCUACGCCUGUCUGAGCGUCGCU

Sequence of entity 4 (5), FASTA

>11IQ_4 5S rRNA (chains 5)
GUCUACGGCCAUACCACCCUGAACGCGCCCGAUCUCGUCUGAUCUCGGAAGCUAAGCAGG
GUCGGGCCUGGUUAGUACUUGGAUGGGAGACCGCCUGGGAAUACCGGGUGCUGUAGGCUU

Sequence of entity 5 (L8), FASTA

>11IQ_5 60S ribosomal protein L8 (chains L8)
GRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKV
VFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPG
DRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPILK
AGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAAR
RTGRLRGT

Sequence of entity 6 (L3), FASTA

>11IQ_6 60S ribosomal protein L3 (chains L3)
SHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREVD
RPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYKN
WHKSKKKAFTKYCKKWQDDAGKRQLDKDFSSMKKYCQVIRVLAHTQMRLLPLRQKKAHLM
EIQVNGGTVAEKLDWARERLEQQVPVSQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKLP
RKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIKN
NASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRALE
KIDLKFIDTTSKFGHGRFQTVEEKKAFMGPLKKD

Sequence of entity 7 (L4), FASTA

>11IQ_7 60S ribosomal protein L4 (chains L4)
ACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGHQ
TSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQKR
YAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDIK
KVYASQRMRAGKGKMRNRRRIQRRGPCVIYNEDNGIVKAFRNIPGITLLNVTKLNILKLA
PGGHVGRFCIWTESAFRKLDDLYGTWRKAASLKSNYNLPMHKMLNTDLSRILKSPEIQRA
LRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVERAAAALAAK
SD

Sequence of entity 8 (L5), FASTA

>11IQ_8 60S ribosomal protein L5 (chains L5)
FVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIIC
QIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQ
VEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPG
YDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNNVTPDMMEEMYKK
AHAAIRENPVYEKKPKREVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAA

Sequence of entity 9 (L6), FASTA

>11IQ_9 60S ribosomal protein L6 (chains L6)
MAGEKAPAAKPDATKKSPAKKADHARGKAKKKTLAEKKPKKGKPHCSRNPVLVRGIGRYS
RSAMYSRKALYKRKYAAPKSRIERKKKREKVLATVTKPVGGDKNGGTRVVKLRKMPRYYP
TEDVPRKLLSHGKKPFSQHVRKLRASITPGTILIILTGRHRGKRVVFLKQLSSGLLLVTG
PLSLNRVPLRRTHQKFVIATSTKIDISGVKIPKHLTDAYFKKKKLRKPRHQEGEIFDTEK
EKYEITEQRKVDQKAVDSQILPKIKAVPQLQGYLRSVFALTNGVYPHKLVF

Sequence of entity 10 (L7), FASTA

>11IQ_10 60S ribosomal protein L7 (chains L7)
NFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYV
PAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWG
YPNLKSVNELIYKRGYGKINKKRIALTDNTLIARSLGKYNIICMEDLIHEIYTVGKHFKE
ANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRMNKKKTTHFVEGGDAGN
REDQINRLIRRMN

Sequence of entity 11 (aa), FASTA

>11IQ_11 Large ribosomal subunit protein eL8 (chains aa)
VVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKVPPAINQFTQV
LDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGKGDVPTKRPPVLRAGVNTVTTL
VENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCILKGKARLGRLVHRKTCTTVAFTQ
VNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG

Sequence of entity 12 (13), FASTA

>11IQ_12 Large ribosomal subunit protein eL13 (chains 13)
APSRNGMILKPHFHKDWQRRVATWFNQPARKIRRRKARQARARRIAPRPAAGPIRPIVRC
PTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPRRRNKSTESLQANVQRLKEYR
SKLVLFPRKPSAPKKGDSSAEELKLATQLTGPVMPIRNVFKKEKARVITEEEKNFKAFAS
LRMARANARLFGIRAKRAKEAAEQDVEKKKSLRMARANAHLFGIRAKRAKEAAEQDVEKK
K

Ligands and cofactors

ID	Name	Formula	Copies
GDP	Guanosine-5'-diphosphate	C10 H15 N5 O11 P2	1
ZN	Zinc ion	Zn	5

Primary citation

In extracto cryo-EM reveals eEF2 as a major hibernation factor on 60S and 80S particles. Seraj, Z., Zottig, X., Huang, C. et al. Elife (2026) 15. DOI 10.7554/eLife.110114 · PubMed

Other PDB entries of the same protein (UniProt G1SCJ6 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7O7Y 2.2 Å, Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a…
7OYD 2.3 Å, Cryo-EM structure of a rabbit 80S ribosome with zebrafish Dap1b
7O7Z 2.4 Å, Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a…
8SCB 2.5 Å, Terminating ribosome with SRI-41315
9MR4 2.65 Å, NAC: Ribosome nascent chain complex(Oxa1L)
9RHU 2.65 Å, Rabbit 80S ribosome in complex with eRF1-AAQ, stalled at the Stop codon in mutated F2A…
8RJB 2.69 Å, Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in…
8VVQ 2.7 Å, Codon sampling state of elongation inhibitor-treated mammalian ribosomes obtained from…
8RJD 2.79 Å, Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in…
8B6C 2.79 Å, Cryo-EM structure of ribosome-Sec61 in complex with cyclotriazadisulfonamide derivative…
6SGC 2.8 Å, Rabbit 80S ribosome stalled on a poly(A) tail
7OBR 2.8 Å, RNC-SRP early complex

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