1AJJ: Low-density lipoprotein receptor

Name: PDB 1AJJ: Ldl receptor ligand-binding module 5, calcium-coordinating
Published: 1997-07-07
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: receptor

Ldl receptor ligand-binding module 5, calcium-coordinating. Determined by X-ray diffraction at 1.7 Å resolution. Released 7 Jul 1997.

Method: X-ray diffraction
Resolution: 1.7 Å
Organism: Homo sapiens
Chains: 1
Atoms: 315
Mol. weight: 4.21 kDa
Ligands: CA
Released: 7 Jul 1997

Explore 1AJJ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1AJJ contains 3 α-helices and 2 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	5-6	2
β-strand	10-11	2	1
β-strand	17-18	2	1
α-helix	20-22	3
α-helix	34-36	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Low-density lipoprotein receptor	A	protein	37	Homo sapiens	P01130 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1AJJ_1 LOW-DENSITY LIPOPROTEIN RECEPTOR (chains A)
PCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCA

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	1

Water and common crystallization additives (SO4) are not listed.

Primary citation

Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module. Fass, D., Blacklow, S., Kim, P.S. et al. Nature (1997) 388:691-693. DOI 10.1038/41798 · PubMed

Other PDB entries of the same protein (UniProt P01130 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2FCW 1.26 Å, Structure of a Complex Between the Pair of the LDL Receptor Ligand-Binding Modules 3-4…
3SO6 1.37 Å, Crystal structure of the LDL receptor tail in complex with autosomal recessive…
1IJQ 1.5 Å, Crystal Structure of the LDL Receptor YWTD-EGF Domain Pair
5OYL 2.25 Å, Vsv G CR2
2W2N 2.3 Å, WT PCSK9-deltaC bound to EGF-A H306Y mutant of LDLR
2W2Q 2.33 Å, PCSK9-deltaC D374H mutant bound to WT EGF-A of LDLR
2W2M 2.4 Å, Wt PCSK9-deltac bound to wt egf-a of ldlr
3BPS 2.41 Å, PCSK9:EGF-A complex
4NE9 2.6 Å, PCSK9 in complex with LDLR peptide
2W2O 2.62 Å, PCSK9-deltaC D374Y mutant bound to WT EGF-A of LDLR
2W2P 2.62 Å, PCSK9-deltaC D374A mutant bound to WT EGF-A of LDLR
3GCW 2.7 Å, PCSK9:EGFA(H306Y)

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