1BE3: Cytochrome BC1 complex from bovine
Cytochrome BC1 complex from bovine. Determined by X-ray diffraction at 3.0 Å resolution. Released 13 Jan 1999.
- Method
- X-ray diffraction
- Resolution
- 3.0 Å
- Organism
- Bos taurus
- Chains
- 11
- Atoms
- 16,222
- Mol. weight
- 243.17 kDa
- Ligands
- HEM, HEC, FES
- Released
- 13 Jan 1999
Explore 1BE3 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
1BE3 contains 100 α-helices and 54 β-strands across 11 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 22 helices, 15 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-9 | 6 | |
| β-strand | 17-18 | 2 | 1 |
| β-strand | 24-25 | 2 | 1 |
| β-strand | 28-29 | 2 | 1 |
| β-strand | 34-39 | 6 | 1 |
| α-helix | 51-54 | 4 | |
| α-helix | 55-62 | 8 | |
| β-strand | 67 | 1 | 2 |
| β-strand | 70 | 1 | 2 |
| α-helix | 74-82 | 9 | |
| β-strand | 85-90 | 6 | 1 |
| β-strand | 95-102 | 8 | 1 |
| α-helix | 103-105 | 3 | |
| α-helix | 106-118 | 13 | |
| α-helix | 124-141 | 18 | |
| α-helix | 145-157 | 13 | |
| α-helix | 162-164 | 3 | |
| α-helix | 171-176 | 6 | |
| α-helix | 179-190 | 12 | |
| β-strand | 196-201 | 6 | 1 |
| α-helix | 205-211 | 7 | |
| β-strand | 239-245 | 7 | 3 |
| β-strand | 251-256 | 6 | 3 |
| α-helix | 266-277 | 12 | |
| β-strand | 279-281 | 3 | 3 |
| α-helix | 287-289 | 3 | |
| α-helix | 293-300 | 8 | |
| β-strand | 306-313 | 8 | 3 |
| β-strand | 318-326 | 9 | 3 |
| α-helix | 331-348 | 18 | |
| α-helix | 351-367 | 17 | |
| α-helix | 372-384 | 13 | |
| α-helix | 392-400 | 9 | |
| α-helix | 404-414 | 11 | |
| β-strand | 421-425 | 5 | 3 |
| α-helix | 434-438 | 5 | |
| α-helix | 439-441 | 3 | |
Chain B: 21 helices, 15 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 28 | 1 | 4 |
| β-strand | 34-37 | 4 | 4 |
| β-strand | 44-51 | 8 | 4 |
| α-helix | 55-57 | 3 | |
| α-helix | 65-71 | 7 | |
| β-strand | 77 | 1 | 5 |
| α-helix | 82-92 | 11 | |
| β-strand | 95 | 1 | 4 |
| β-strand | 97-100 | 4 | 6 |
| β-strand | 105-112 | 8 | 4 |
| α-helix | 113-115 | 3 | |
| α-helix | 116-128 | 13 | |
| β-strand | 130 | 1 | 5 |
| α-helix | 134-140 | 7 | |
| α-helix | 142-151 | 10 | |
| α-helix | 155-167 | 13 | |
| α-helix | 183-185 | 3 | |
| α-helix | 188-198 | 11 | |
| α-helix | 201-203 | 3 | |
| β-strand | 204-208 | 5 | 4 |
| α-helix | 213-223 | 11 | |
| β-strand | 243-247 | 5 | 7 |
| β-strand | 252-260 | 9 | 7 |
| α-helix | 261-263 | 3 | |
| α-helix | 267-279 | 13 | |
| β-strand | 285 | 1 | 1 |
| α-helix | 294-302 | 9 | |
| β-strand | 308-315 | 8 | 7 |
| β-strand | 320-329 | 10 | 7 |
| α-helix | 333-348 | 16 | |
| α-helix | 355-372 | 18 | |
| α-helix | 375-388 | 14 | |
| α-helix | 395-404 | 10 | |
| α-helix | 407-418 | 12 | |
| β-strand | 423-428 | 6 | 7 |
| α-helix | 436-438 | 3 | |
Chain C: 20 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10-14 | 5 | |
| α-helix | 15-18 | 4 | |
| β-strand | 22-24 | 3 | 8 |
| α-helix | 33-51 | 19 | |
| α-helix | 62-72 | 11 | |
| β-strand | 73 | 1 | 9 |
| α-helix | 76-104 | 29 | |
| α-helix | 106-108 | 3 | |
| α-helix | 110-130 | 21 | |
| β-strand | 136 | 1 | 10 |
| α-helix | 137-149 | 13 | |
| α-helix | 150-152 | 3 | |
| α-helix | 157-165 | 9 | |
| α-helix | 172-200 | 29 | |
| α-helix | 214-216 | 3 | |
| β-strand | 217-219 | 3 | 8 |
| α-helix | 222-245 | 24 | |
| β-strand | 258 | 1 | 10 |
| α-helix | 272-282 | 11 | |
| α-helix | 287-307 | 21 | |
| α-helix | 315-317 | 3 | |
| α-helix | 319-339 | 21 | |
| α-helix | 345-360 | 16 | |
| α-helix | 361-365 | 5 | |
| α-helix | 366-376 | 11 | |
Chain D: 11 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 23-32 | 10 | |
| α-helix | 33-37 | 5 | |
| β-strand | 47 | 1 | 11 |
| α-helix | 58-71 | 14 | |
| α-helix | 74-76 | 3 | |
| α-helix | 89 | 1 | |
| β-strand | 90 | 1 | 11 |
| α-helix | 91-93 | 3 | |
| α-helix | 98-104 | 7 | |
| α-helix | 113-115 | 3 | |
| α-helix | 123-131 | 9 | |
| α-helix | 179-194 | 16 | |
| α-helix | 198-231 | 34 | |
| β-strand | 234-237 | 4 | 3 |
Chain E: 6 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 14 | 1 | 12 |
| α-helix | 16-18 | 3 | |
| α-helix | 26-60 | 35 | |
| β-strand | 65 | 1 | 9 |
| α-helix | 66-73 | 8 | |
| β-strand | 86 | 1 | 13 |
| β-strand | 89-91 | 3 | 13 |
| β-strand | 94-100 | 7 | 13 |
| α-helix | 103-110 | 8 | |
| α-helix | 123-125 | 3 | |
| β-strand | 129 | 1 | 13 |
| β-strand | 132-136 | 5 | 13 |
| α-helix | 151-153 | 3 | |
| β-strand | 156-158 | 3 | 14 |
| β-strand | 163-165 | 3 | 14 |
| β-strand | 171-173 | 3 | 14 |
| β-strand | 185-187 | 3 | 15 |
| β-strand | 193-195 | 3 | 15 |
Chain F: 9 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-11 | 3 | |
| α-helix | 13-23 | 11 | |
| α-helix | 25-29 | 5 | |
| α-helix | 33-36 | 4 | |
| α-helix | 41-48 | 8 | |
| α-helix | 52-71 | 20 | |
| α-helix | 74-76 | 3 | |
| α-helix | 77-79 | 3 | |
| α-helix | 90-106 | 17 | |
Chain G: 2 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 11-18 | 8 | 3 |
| β-strand | 23 | 1 | 12 |
| α-helix | 29-66 | 38 | |
| α-helix | 67-71 | 5 | |
Chain H: 4 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 16-25 | 10 | |
| α-helix | 28-40 | 13 | |
| α-helix | 50-52 | 3 | |
| α-helix | 55-75 | 21 | |
3 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Cytochrome BC1 complex | A | protein | 446 | Bos taurus | P31800 (AlphaFold model) |
| Cytochrome BC1 complex | B | protein | 439 | Bos taurus | P23004 (AlphaFold model) |
| Cytochrome BC1 complex | C | protein | 379 | Bos taurus | P00157 (AlphaFold model) |
| Cytochrome BC1 complex | D | protein | 241 | Bos taurus | P00125 (AlphaFold model) |
| Cytochrome BC1 complex | E | protein | 196 | Bos taurus | P13272 |
| Cytochrome BC1 complex | F | protein | 110 | Bos taurus | P00129 |
| Cytochrome BC1 complex | G | protein | 81 | Bos taurus | P13271 |
| Cytochrome BC1 complex | H | protein | 78 | Bos taurus | P00126 |
| Cytochrome BC1 complex | I | protein | 78 | Bos taurus | P13272 |
| Cytochrome BC1 complex | J | protein | 62 | Bos taurus | P00130 |
| Cytochrome BC1 complex | K | protein | 56 | Bos taurus | P07552 |
Sequence of entity 1 (A), FASTA
>1BE3_1 CYTOCHROME BC1 COMPLEX (chains A)
TATYAQALQSVPETQVSQLDNGLRVASEQSSQPTCTVGVWIDAGSRYESEKNNGAGYFVE
HLAFKGTKNRPGNALEKEVESMGAHLNAYSTREHTAYYIKALSKDLPKAVELLADIVQNC
SLEDSQIEKERDVILQELQENDTSMRDVVFNYLHATAFQGTPLAQSVEGPSENVRKLSRA
DLTEYLSRHYKAPRMVLAAAGGLEHRQLLDLAQKHFSGLSGTYDEDAVPTLSPCRFTGSQ
ICHREDGLPLAHVAIAVEGPGWAHPDNVALQVANAIIGHYDCTYGGGAHLSSPLASIAAT
NKLCQSFQTFNICYADTGLLGAHFVCDHMSIDDMMFVLQGQWMRLCTSATESEVLRGKNL
LRNALVSHLDGTTPVCEDIGRSLLTYGRRIPLAEWESRIAEVDARVVREVCSKYFYDQCP
AVAGFGPIEQLPDYNRIRSGMFWLRF
Sequence of entity 2 (B), FASTA
>1BE3_2 CYTOCHROME BC1 COMPLEX (chains B)
SLKVAPKVKATEAPAGVPPHPQDLEFTRLPNGLVIASLENYAPASRIGLFIKAGSRYENS
NNLGTSHLLRLASSLTTKGASSFKITRGIEAVGGKLSVTSTRENMAYTVECLRDDVDILM
EFLLNVTTAPEFRRWEVAALQPQLRIDKAVALQNPQAHVIENLHAAAYRNALANSLYCPD
YRIGKVTPVELHDYVQNHFTSARMALIGLGVSHPVLKQVAEQFLNIRGGLGLSGAKAKYH
GGEIREQNGDSLVHAALVAESAAIGSAEANAFSVLQHVLGAGPHVKRGSNATSSLYQAVA
KGVHQPFDVSAFNASYSDSGLFGFYTISQAASAGDVIKAAYNQVKTIAQGNLSNPDVQAA
KNKLKAGYLMSVESSEGFLDEVGSQALAAGSYTPPSTVLQQIDAVADADVINAAKKFVSG
RKSMAASGNLGHTPFIDEL
Sequence of entity 3 (C), FASTA
>1BE3_3 CYTOCHROME BC1 COMPLEX (chains C)
MTNIRKSHPLMKIVNNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTT
TAFSSVTHICRDVNYGWIIRYMHANGASMFFICLYMHVGRGLYYGSYTFLETWNIGVILL
LTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFA
FHFILPFIIMAIAMVHLLFLHETGSNNPTGISSDVDKIPFHPYYTIKDILGALLLILALM
LLVLFAPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAFSILI
LALIPLLHTSKQRSMMFRPLSQCLFWALVADLLTLTWIGGQPVEHPYITIGQLASVLYFL
LILVLMPTAGTIENKLLKW
Sequence of entity 4 (D), FASTA
>1BE3_4 CYTOCHROME BC1 COMPLEX (chains D)
SDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCSSCHSMDYVAYRHLVGVCYTEDE
AKALAEEVEVQDGPNEDGEMFMRPGKLSDYFPKPYPNPEAARAANNGALPPDLSYIVRAR
HGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIGMAPPIYNEVLEFDDGTPATMS
QVAKDVCTFLRWAAEPEHDHRKRMGLKMLLMMGLLLPLVYAMKRHKWSVLKSRKLAYRPP
K
Sequence of entity 5 (E), FASTA
>1BE3_5 CYTOCHROME BC1 COMPLEX (chains E)
SHTDIKVPDFSDYRRPEVLDSTKSSKESSEARKGFSYLVTATTTVGVAYAAKNVVSQFVS
SMSASADVLAMSKIEIKLSDIPEGKNMAFKWRGKPLFVRHRTKKEIDQEAAVEVSQLRDP
QHDLERVKKPEWVILIGVCTHLGCVPIANAGDFGGYYCPCHGSHYDASGRIRKGPAPLNL
EVPSYEFTSDDMVIVG
Sequence of entity 6 (F), FASTA
>1BE3_6 CYTOCHROME BC1 COMPLEX (chains F)
AGRPAVSASSRWLEGIRKWYYNAAGFNKLGLMRDDTIHENDDVKEAIRRLPENLYDDRVF
RIKRALDLSMRQQILPKEQWTKYEEDKSYLEPYLKEVIRERKEREEWAKK
Sequence of entity 7 (G), FASTA
>1BE3_7 CYTOCHROME BC1 COMPLEX (chains G)
GRQFGHLTRVRHVITYSLSPFEQRAFPHYFSKGIPNVLRRTRACILRVAPPFVAFYLVYT
WGTQEFEKSKRKNPAAYENDR
Sequence of entity 8 (H), FASTA
>1BE3_8 CYTOCHROME BC1 COMPLEX (chains H)
GDPKEEEEEEEELVDPLTTVREQCEQLEKCVKARERLELCDERVSSRSQTEEDCTEELLD
FLHARDHCVAHKLFNSLK
Sequence of entity 9 (I), FASTA
>1BE3_9 CYTOCHROME BC1 COMPLEX (chains I)
MLSVAARSGPFAPVLSATSRGVAGALRPLVQAAVPATSESPVLDLKRSVLCRESLRGQAA
GRPLVASVSLNVPASVRY
Sequence of entity 10 (J), FASTA
>1BE3_10 CYTOCHROME BC1 COMPLEX (chains J)
VAPTLTARLYSLLFRRTSTFALTIVVGALFFERAFDQGADAIYEHINEGKLWKHIKHKYE
NK
Sequence of entity 11 (K), FASTA
>1BE3_11 CYTOCHROME BC1 COMPLEX (chains K)
MLTRFLGPRYRQLARNWVPTAQLWGAVGAVGLVSATDSRLILDWVPYINGKFKKDD
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| HEM | Protoporphyrin IX containing FE | C34 H32 Fe N4 O4 | 2 |
| HEC | Heme C | C34 H36 Fe N4 O4 | 1 |
| FES | FE2/S2 (inorganic) cluster | Fe2 S2 | 1 |
Primary citation
Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex. Iwata, S., Lee, J.W., Okada, K. et al. Science (1998) 281:64-71. DOI 10.1126/science.281.5373.64 · PubMed
Other PDB entries of the same protein (UniProt P31800 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 1PP9 2.1 Å, Bovine cytochrome bc1 complex with stigmatellin bound
- 1PPJ 2.1 Å, Bovine cytochrome bc1 complex with stigmatellin and antimycin
- 2A06 2.1 Å, Bovine cytochrome bc1 complex with stigmatellin bound
- 9W2X 2.2 Å, Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-1
- 2FYU 2.26 Å, Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor
- 1L0L 2.35 Å, structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone
- 1NTM 2.4 Å, Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom
- 9W2Y 2.4 Å, Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-2
- 1L0N 2.6 Å, native structure of bovine mitochondrial cytochrome bc1 complex
- 1NTK 2.6 Å, Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1
- 1NTZ 2.6 Å, Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone
- 1SQX 2.6 Å, Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A
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