1BFS: Nf-kb P50 homodimer

Structure of nf-kb P50 homodimer bound to a kb site. Determined by X-ray diffraction at 2.2 Å resolution. Released 28 Jan 1998.

Method: X-ray diffraction
Resolution: 2.2 Å
Organism: Mus musculus
Chains: 1
Atoms: 936
Mol. weight: 12.26 kDa
Released: 28 Jan 1998

Explore 1BFS in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1BFS contains 4 α-helices and 11 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	250-253	4	1
β-strand	257-259	3	2
β-strand	265-270	6	1
β-strand	279-285	7	2
α-helix	287-289	3
β-strand	291-295	5	2
β-strand	297	1	1
α-helix	300-302	3
β-strand	303	1	1
β-strand	308-312	5	1
α-helix	313-316	4
β-strand	325-332	8	2
β-strand	339	1	2
α-helix	340-342	3
β-strand	343-348	6	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Nuclear factor nf-kappa-B P50	A	protein	106	Mus musculus	P25799 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1BFS_1 NUCLEAR FACTOR NF-KAPPA-B P50 (chains A)
ASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSPTDVH
RQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPE

Primary citation

The role of DNA in the mechanism of NFkappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits. Huang, D.B., Huxford, T., Chen, Y.Q. et al. Structure (1997) 5:1427-1436. DOI 10.1016/S0969-2126(97)00293-1 · PubMed

Other PDB entries of the same protein (UniProt P25799 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1U36 1.89 Å, Crystal structure of WLAC mutant of dimerisation domain of NF-kB p50 transcription factor
1U3Z 1.9 Å, Crystal structure of MLAC mutant of dimerisation domain of NF-kB p50 transcription factor
1U3J 1.9 Å, Crystal structure of MLAV mutant of dimerisation domain of NF-kB p50 transcription factor
1U3Y 1.9 Å, Crystal structure of ILAC mutant of dimerisation domain of NF-kB p50 transcription factor
9BOR 2.0 Å, IkappaBzeta ankyrin repeat domain:NF-kappaB p50 homodimer complex at 2.0 Angstrom…
1U41 2.2 Å, Crystal structure of YLGV mutant of dimerisation domain of NF-kB p50 transcription factor
1IKN 2.3 Å, Ikappabalpha/nf-kappab complex
1NFK 2.3 Å, Structure of the nuclear factor kappa-B (nf-kb) P50 homodimer
1OOA 2.45 Å, Crystal structure of nf-kB(p50)2 complexed to a high-affinity RNA aptamer
1U42 2.7 Å, Crystal structure of MLAM mutant of dimerisation domain of NF-kB p50 transcription factor
1LEI 2.7 Å, The kB DNA sequence from the HLV-LTR functions as an allosteric regulator of HIV…
1LE5 2.75 Å, Crystal structure of a NF-kB heterodimer bound to an IFNb-kB

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