1BR8: Protein

Implications for function and therapy of a 2.9A structure of binary-complexed antithrombin. Determined by X-ray diffraction at 2.9 Å resolution. Released 2 Sept 1998.

Method: X-ray diffraction
Resolution: 2.9 Å
Organism: Homo sapiens
Chains: 3
Atoms: 6,526
Mol. weight: 99.29 kDa
Released: 2 Sept 1998

Explore 1BR8 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1BR8 contains 29 α-helices and 46 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain I: 15 helices, 21 β-strands

Element	Residues	Length	Sheet
β-strand	24	1	8
α-helix	25-26	2
α-helix	48-68	21
β-strand	76-78	3	9
α-helix	80-90	11
α-helix	91-93	3
α-helix	96-105	10
α-helix	108-111	4
β-strand	115	1	8
α-helix	118-130	13
β-strand	138-149	12	10
β-strand	154	1	11
α-helix	156-166	11
α-helix	168	1
β-strand	169-173	5	10
α-helix	179-192	14
β-strand	213-223	11	10
β-strand	225	1	12
α-helix	228-230	3
α-helix	231-233	3
β-strand	235-238	4	13
β-strand	248-257	10	13
β-strand	259-263	5	9
β-strand	267-273	7	9
β-strand	274	1	12
β-strand	279-285	7	9
α-helix	292-298	7
α-helix	301-309	9
β-strand	315-321	7	13
β-strand	323-330	8	10
α-helix	332-338	7
β-strand	355	1	11
β-strand	364-375	12	10
β-strand	400-403	4	13
β-strand	408-414	7	9
β-strand	419-426	8	9

Chain L: 14 helices, 24 β-strands

Element	Residues	Length	Sheet
α-helix	46-68	23
β-strand	76-78	3	1
α-helix	80-91	12
α-helix	96-105	10
α-helix	108-110	3
α-helix	119-131	13
β-strand	139-142	4	2
β-strand	145	1	2
β-strand	146	1	3
β-strand	149	1	4
β-strand	153-154	2	5
α-helix	156-164	9
β-strand	170	1	3
β-strand	173	1	4
α-helix	175-193	19
β-strand	214-224	11	2
β-strand	225	1	6
β-strand	235-238	4	7
α-helix	239-241	3
β-strand	248-251	4	7
β-strand	254-262	9	1
α-helix	264-266	3
β-strand	268-273	6	1
β-strand	274	1	6
β-strand	279-285	7	1
α-helix	286	1
α-helix	293-297	5
α-helix	301-310	10
β-strand	312-318	7	1
β-strand	321	1	7
β-strand	323-330	8	2
α-helix	332-338	7
α-helix	342-344	3
β-strand	355-357	3	5
β-strand	364-375	12	2
β-strand	379-390	12	2
β-strand	409-414	6	1
β-strand	419-425	7	1

Chain P: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	2-11	10	10

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Protein (antithrombin-III)	I, L	protein	432	Homo sapiens	P01008 (AlphaFold model)
Protein (peptide)	P	protein	12

Sequence of entity 1 (I, L), FASTA

>1BR8_1 PROTEIN (ANTITHROMBIN-III) (chains I, L)
HGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFAT
TFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIH
FFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAE
QSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFY
KADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELT
PEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRD
DLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTI
IFMGRVANPCVK

Sequence of entity 2 (P), FASTA

>1BR8_2 PROTEIN (PEPTIDE) (chains P)
SEAAASTAVVIA

Primary citation

Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin. Skinner, R., Chang, W.S., Jin, L. et al. J Mol Biol (1998) 283:9-14. DOI 10.1006/jmbi.1998.2083 · PubMed

Other PDB entries of the same protein (UniProt P01008 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3KCG 1.7 Å, Crystal structure of the antithrombin-factor IXa-pentasaccharide complex
2B5T 2.1 Å, 2.1 Angstrom structure of a nonproductive complex between antithrombin, synthetic…
1TB6 2.5 Å, 2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex
1E04 2.6 Å, Plasma beta antithrombin-III
1JVQ 2.6 Å, Crystal structure at 2.6A of the ternary complex between antithrombin, a P14-P8 reactive…
1NQ9 2.6 Å, Crystal Structure of Antithrombin in the Pentasaccharide-Bound Intermediate State
2ANT 2.6 Å, The 2.6 a structure of antithrombin indicates a conformational change at the heparin…
1E05 2.62 Å, Plasma alpha antithrombin-III
1OYH 2.62 Å, Crystal Structure of P13 Alanine Variant of Antithrombin
1R1L 2.7 Å, Structure of dimeric antithrombin complexed with a P14-P9 reactive loop peptide and an…
2BEH 2.7 Å, Crystal structure of antithrombin variant S137A/V317C/T401C with plasma latent…
1T1F 2.75 Å, Crystal Structure of Native Antithrombin in its Monomeric Form

Browse structure collections

About this viewer

MolViewer shows 1BR8 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.