2ANT: Antithrombin

The 2.6 a structure of antithrombin indicates a conformational change at the heparin binding site. Determined by X-ray diffraction at 2.6 Å resolution. Released 16 Jun 1997.

Method: X-ray diffraction
Resolution: 2.6 Å
Organism: Homo sapiens
Chains: 2
Atoms: 6,636
Mol. weight: 98.64 kDa
Ligands: NAA
Released: 16 Jun 1997

Explore 2ANT in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2ANT contains 26 α-helices and 40 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain I: 14 helices, 20 β-strands

Element	Residues	Length	Sheet
α-helix	49-68	20
β-strand	76-78	3	6
α-helix	80-90	11
α-helix	91-93	3
α-helix	98-105	8
α-helix	118-130	13
β-strand	140-149	10	7
α-helix	156-161	6
α-helix	162-166	5
β-strand	169-173	5	7
α-helix	175-192	18
β-strand	213-221	9	7
β-strand	223-224	2	7
β-strand	225	1	8
α-helix	231-233	3
β-strand	235-240	6	9
β-strand	246-252	7	9
β-strand	255-262	8	6
β-strand	268-273	6	6
β-strand	274	1	8
β-strand	279-285	7	6
α-helix	292-298	7
α-helix	301-310	10
β-strand	312-319	8	6
β-strand	320-321	2	9
β-strand	323-330	8	7
α-helix	332-338	7
α-helix	342-344	3
α-helix	352-354	3
β-strand	364-375	12	7
β-strand	379-380	2	7
β-strand	401-403	3	6
β-strand	408-414	7	6
β-strand	419-426	8	6

Chain L: 12 helices, 20 β-strands

Element	Residues	Length	Sheet
α-helix	45-69	25
β-strand	76-78	3	1
α-helix	80-91	12
α-helix	98-105	8
α-helix	108-110	3
α-helix	116-131	16
β-strand	138-146	9	2
β-strand	149	1	3
β-strand	154	1	4
α-helix	156-165	10
β-strand	169-170	2	2
β-strand	173	1	3
α-helix	175-193	19
β-strand	214-224	11	2
β-strand	225	1	5
β-strand	235-240	6	1
β-strand	246-262	17	1
α-helix	264-266	3
β-strand	268-273	6	1
β-strand	274	1	5
β-strand	279-285	7	1
α-helix	292-297	6
α-helix	301-310	10
β-strand	312-321	10	1
β-strand	323-330	8	2
α-helix	332-337	6
α-helix	342-344	3
β-strand	355	1	4
β-strand	364-375	12	2
β-strand	379-390	12	2
β-strand	409-414	6	1
β-strand	419-425	7	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Antithrombin	I, L	protein	432	Homo sapiens	P01008 (AlphaFold model)

Sequence of entity 1 (I, L), FASTA

>2ANT_1 ANTITHROMBIN (chains I, L)
HGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFAT
TFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIH
FFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAE
QSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFY
KADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELT
PEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRD
DLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTI
IFMGRVANPCVK

Ligands and cofactors

ID	Name	Formula	Copies
NAA	2-acetamido-2-deoxy-beta-D-allopyranose	C8 H15 N O6	2

Primary citation

The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site. Skinner, R., Abrahams, J.P., Whisstock, J.C. et al. J Mol Biol (1997) 266:601-609. DOI 10.1006/jmbi.1996.0798 · PubMed

Other PDB entries of the same protein (UniProt P01008 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3KCG 1.7 Å, Crystal structure of the antithrombin-factor IXa-pentasaccharide complex
2B5T 2.1 Å, 2.1 Angstrom structure of a nonproductive complex between antithrombin, synthetic…
1TB6 2.5 Å, 2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex
1E04 2.6 Å, Plasma beta antithrombin-III
1JVQ 2.6 Å, Crystal structure at 2.6A of the ternary complex between antithrombin, a P14-P8 reactive…
1NQ9 2.6 Å, Crystal Structure of Antithrombin in the Pentasaccharide-Bound Intermediate State
1E05 2.62 Å, Plasma alpha antithrombin-III
1OYH 2.62 Å, Crystal Structure of P13 Alanine Variant of Antithrombin
1R1L 2.7 Å, Structure of dimeric antithrombin complexed with a P14-P9 reactive loop peptide and an…
2BEH 2.7 Å, Crystal structure of antithrombin variant S137A/V317C/T401C with plasma latent…
1T1F 2.75 Å, Crystal Structure of Native Antithrombin in its Monomeric Form
1DZG 2.8 Å, N135Q-S380C-antithrombin-III

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2ANT is part of these collections:

Blood clotting

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