Crystal structure of the human CDK2 kinase complex with cell cycle-regulatory protein CKSHS1. Determined by X-ray diffraction at 2.6 Å resolution. Released 9 Sept 1998.
Explore 1BUH in 3D Show helices and sheets RCSB PDB PDBe
1BUH contains 23 α-helices and 17 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 4-12 | 9 | 1 |
| β-strand | 17-23 | 7 | 1 |
| β-strand | 29-36 | 8 | 1 |
| α-helix | 49-53 | 5 | |
| α-helix | 54-57 | 4 | |
| β-strand | 63 | 1 | 2 |
| β-strand | 66-72 | 7 | 1 |
| β-strand | 75-80 | 6 | 1 |
| β-strand | 85-86 | 2 | 2 |
| α-helix | 87-93 | 7 | |
| α-helix | 101-120 | 20 | |
| α-helix | 130-132 | 3 | |
| β-strand | 133-135 | 3 | 2 |
| β-strand | 141-143 | 3 | 2 |
| α-helix | 149-152 | 4 | |
| β-strand | 157 | 1 | 3 |
| α-helix | 162 | 1 | |
| β-strand | 163 | 1 | 3 |
| α-helix | 164 | 1 | |
| α-helix | 171-174 | 4 | |
| α-helix | 183-198 | 16 | |
| α-helix | 208-219 | 12 | |
| α-helix | 230-232 | 3 | |
| β-strand | 245 | 1 | 4 |
| α-helix | 246-247 | 2 | |
| α-helix | 248-251 | 4 | |
| α-helix | 257-266 | 10 | |
| α-helix | 275-276 | 2 | |
| α-helix | 277-280 | 4 | |
| α-helix | 284-288 | 5 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 7-8 | 2 | 5 |
| α-helix | 9-11 | 3 | |
| β-strand | 12-13 | 2 | 5 |
| β-strand | 17-23 | 7 | 5 |
| α-helix | 24-25 | 2 | |
| α-helix | 26-29 | 4 | |
| α-helix | 37-39 | 3 | |
| α-helix | 40-45 | 6 | |
| β-strand | 55-58 | 4 | 5 |
| β-strand | 66-72 | 7 | 5 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Protein (CDK2 human) | A | protein | 298 | Homo sapiens | P24941 (AlphaFold model) |
| Protein (CKSHS1 human) | B | protein | 79 | Homo sapiens | P61024 (AlphaFold model) |
>1BUH_1 PROTEIN (CDK2 HUMAN) (chains A) MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
>1BUH_2 PROTEIN (CKSHS1 HUMAN) (chains B) MSHKQIYYSDKYDDEEFEYRHVMLPKDIAKLVPKTHLMSESEWRNLGVQQSQGWVHYMIH EPEPHILLFRRPLPKKPKK
Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1. Bourne, Y., Watson, M.H., Hickey, M.J. et al. Cell (1996) 84:863-874. DOI 10.1016/S0092-8674(00)81065-X · PubMed
Other PDB entries of the same protein (UniProt P24941 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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