1CDM: Peptide calmodulin-dependent protein kinase II

Modulation of calmodulin plasticity in molecular recognition on the basis of X-ray structures. Determined by X-ray diffraction at 2.0 Å resolution. Released 31 Aug 1994.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: Bos taurus
Chains: 2
Atoms: 1,236
Mol. weight: 19.32 kDa
Ligands: CA
Released: 31 Aug 1994

Explore 1CDM in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1CDM contains 9 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	26-27	2	1
α-helix	29-38	10
α-helix	45-53	9
β-strand	63-64	2	1
α-helix	65-72	8
α-helix	85-92	8
β-strand	99-100	2	2
α-helix	102-111	10
α-helix	118-128	11
β-strand	136-137	2	2
α-helix	138-145	8

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	295-309	15

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Peptide calmodulin-dependent protein kinase II	A	protein	144	Bos taurus	P62157 (AlphaFold model)
Calmodulin	B	protein	25		P11275 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1CDM_1 PEPTIDE CALMODULIN-DEPENDENT PROTEIN KINASE II (chains A)
LTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTI
DFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDE
MIREADIDGDGQVNYEEFVQMMTA

Sequence of entity 2 (B), FASTA

>1CDM_2 CALMODULIN (chains B)
LKKFNARRKLKGAILTTMLATRNFS

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	4

Primary citation

Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures. Meador, W.E., Means, A.R., Quiocho, F.A. Science (1993) 262:1718-1721. PubMed

Other PDB entries of the same protein (UniProt P62157 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3IF7 1.6 Å, Structure of Calmodulin complexed with its first endogenous inhibitor,…
1FW4 1.7 Å, Crystal structure of E. Coli fragment TR2C from calmodulin to 1.7 a resolution
1PRW 1.7 Å, Crystal structure of bovine brain Ca++ calmodulin in a compact form
1CM1 2.0 Å, Motions of calmodulin-single-conformer refinement
1CM4 2.0 Å, Motions of calmodulin-four-conformer refinement
1LIN 2.0 Å, Calmodulin complexed with trifluoperazine (1:4 complex)
1XA5 2.12 Å, Structure of Calmodulin in complex with KAR-2, a bis-indol alkaloid
2F2O 2.17 Å, Structure of calmodulin bound to a calcineurin peptide: a new way of making an old…
1QIW 2.3 Å, Calmodulin complexed with N-(3,3,-diphenylpropyl)-N'-[1-R-(3,4-bis-butoxyphenyl)-ethyl]-p…
2FOT 2.45 Å, Crystal structure of the complex between calmodulin and alphaII-spectrin
2F2P 2.6 Å, Structure of calmodulin bound to a calcineurin peptide: a new way of making an old…
1QIV 2.64 Å, Calmodulin complexed with N-(3,3,-diphenylpropyl)-N'-[1-R-(3,4-bis-butoxyphenyl)-ethyl]-p…

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