Anti-P24 (HIV-1) FAB fragment CB41 complexed with an epitope-unrelated peptide. Determined by X-ray diffraction at 2.75 Å resolution. Released 31 Mar 1999.
Explore 1CFS in 3D Show helices and sheets RCSB PDB PDBe
1CFS contains 9 α-helices and 43 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 4-7 | 4 | 1 |
| β-strand | 10-13 | 4 | 2 |
| β-strand | 19-25 | 7 | 1 |
| β-strand | 33-38 | 6 | 2 |
| β-strand | 45-49 | 5 | 2 |
| β-strand | 53-54 | 2 | 2 |
| α-helix | 55 | 1 | |
| β-strand | 62-64 | 3 | 1 |
| β-strand | 67 | 1 | 1 |
| β-strand | 70-75 | 6 | 1 |
| α-helix | 80-82 | 3 | |
| β-strand | 85-90 | 6 | 2 |
| α-helix | 96 | 1 | |
| β-strand | 97-98 | 2 | 2 |
| β-strand | 102-106 | 5 | 2 |
| β-strand | 111 | 1 | 3 |
| β-strand | 114-118 | 5 | 4 |
| α-helix | 119-121 | 3 | |
| α-helix | 122-125 | 4 | |
| β-strand | 129-139 | 11 | 4 |
| β-strand | 140 | 1 | 3 |
| β-strand | 144-150 | 7 | 5 |
| β-strand | 153-154 | 2 | 5 |
| β-strand | 159-163 | 5 | 4 |
| β-strand | 173-182 | 10 | 4 |
| α-helix | 183-186 | 4 | |
| β-strand | 191-198 | 8 | 5 |
| β-strand | 201-210 | 10 | 5 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 4-6 | 3 | 6 |
| β-strand | 10-12 | 3 | 7 |
| β-strand | 18-24 | 7 | 6 |
| α-helix | 29-31 | 3 | |
| β-strand | 34-40 | 7 | 7 |
| β-strand | 44-51 | 8 | 7 |
| β-strand | 58-60 | 3 | 7 |
| α-helix | 62-64 | 3 | |
| β-strand | 68-73 | 6 | 6 |
| β-strand | 78-83 | 6 | 6 |
| α-helix | 88-90 | 3 | |
| β-strand | 92-97 | 6 | 7 |
| β-strand | 102 | 1 | 7 |
| β-strand | 106-110 | 5 | 7 |
| β-strand | 116 | 1 | 8 |
| β-strand | 119-123 | 5 | 9 |
| β-strand | 135-144 | 10 | 9 |
| β-strand | 145 | 1 | 8 |
| β-strand | 150-153 | 4 | 10 |
| β-strand | 162-164 | 3 | 9 |
| β-strand | 168-170 | 3 | 9 |
| β-strand | 173-182 | 10 | 9 |
| β-strand | 193-198 | 6 | 10 |
| β-strand | 203-208 | 6 | 10 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Protein (IGG2A kappa antibody CB41 (light chain)) | A | protein | 214 | Mus musculus | P01837 (AlphaFold model) |
| Protein (IGG2A kappa antibody CB41 (heavy chain)) | B | protein | 213 | Mus musculus | P01864 (AlphaFold model) |
| Protein (antigen bound peptide) | C | protein | 11 |
>1CFS_1 PROTEIN (IGG2A KAPPA ANTIBODY CB41 (LIGHT CHAIN)) (chains A) DIKMTQSPSSMYTSLGERVTITCKASQDINSFLTWFLQKPGKSPKTLIYRANRLMIGVPS RFSGSGSGQTYSLTISSLEYEDMGIYYCLQYDDFPLTFGAGTKLDLKRADAAPTVSIFPP SSEQLTSGGASVVCFLNNFYPKEINVKWKIDGSERQNGVLDSWTEQDSKDSTYSMSSTLT LTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC
>1CFS_2 PROTEIN (IGG2A KAPPA ANTIBODY CB41 (HEAVY CHAIN)) (chains B) QDQLQQSGAELVRPGASVKLSCKALGYIFTDYEIHWVKQTPVHGLEWIGGIHPGSSGTAY NQKFKGKATLTADKSSTTAFMELSSLTSEDSAVYYCTRKDYWGQGTLVTVSAAKTTAPSV YPLVPVCGGTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPALLQSGLYTLSSSV TVTSNTWPSQTITCNVAHPASSTKVDKKIEPRV
>1CFS_3 PROTEIN (ANTIGEN BOUND PEPTIDE) (chains C) GLYEWGGARIT
Crystallographic analysis of anti-p24 (HIV-1) monoclonal antibody cross-reactivity and polyspecificity. Keitel, T., Kramer, A., Wessner, H. et al. Cell (1997) 91:811-820. DOI 10.1016/S0092-8674(00)80469-9 · PubMed
Other PDB entries of the same protein (UniProt P01837 (AlphaFold model), which also has an AlphaFold model), best resolution first:
MolViewer shows 1CFS directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.