The high-resolution X-ray crystal structure of the complex formed between subtilisin carlsberg and eglin C, an elastase inhibitor from the leech hirudo medicinalis. Structural analysis, subtilisin structure and interface geometry. Determined by X-ray diffraction at 1.2 Å resolution. Released 16 Jul 1988.
Explore 1CSE in 3D Show helices and sheets RCSB PDB PDBe
1CSE contains 15 α-helices and 23 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 7-11 | 5 | |
| α-helix | 13-19 | 7 | |
| β-strand | 27-32 | 6 | 1 |
| β-strand | 44-49 | 6 | 1 |
| α-helix | 64-73 | 10 | |
| β-strand | 89-94 | 6 | 1 |
| β-strand | 101 | 1 | 2 |
| α-helix | 104-116 | 13 | |
| β-strand | 121-124 | 4 | 1 |
| β-strand | 126-127 | 2 | 2 |
| β-strand | 128 | 1 | 3 |
| α-helix | 133-145 | 13 | |
| β-strand | 148-152 | 5 | 1 |
| β-strand | 167 | 1 | 3 |
| β-strand | 175-180 | 6 | 1 |
| α-helix | 185 | 1 | |
| β-strand | 186 | 1 | 1 |
| α-helix | 187 | 1 | |
| β-strand | 198-201 | 4 | 1 |
| β-strand | 205-209 | 5 | 4 |
| β-strand | 213-217 | 5 | 4 |
| α-helix | 220-237 | 18 | |
| α-helix | 243-252 | 10 | |
| α-helix | 254 | 1 | |
| β-strand | 255 | 1 | 1 |
| α-helix | 256 | 1 | |
| α-helix | 260-263 | 4 | |
| β-strand | 267 | 1 | 1 |
| α-helix | 270-273 | 4 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 9 | 1 | 5 |
| α-helix | 11-13 | 3 | |
| β-strand | 17 | 1 | 5 |
| α-helix | 18-28 | 11 | |
| β-strand | 33-38 | 6 | 5 |
| β-strand | 43-44 | 2 | 2 |
| β-strand | 51-57 | 7 | 5 |
| β-strand | 62-63 | 2 | 5 |
| β-strand | 68-69 | 2 | 5 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Subtilisin carlsberg | E | protein | 274 | Bacillus subtilis | P00780 (AlphaFold model) |
| Eglin C | I | protein | 70 | Hirudo medicinalis | P01051 (AlphaFold model) |
>1CSE_1 SUBTILISIN CARLSBERG (chains E) AQTVPYGIPLIKADKVQAQGFKGANVKVAVLDTGIQASHPDLNVVGGASFVAGEAYNTDG NGHGTHVAGTVAALDNTTGVLGVAPSVSLYAVKVLNSSGSGSYSGIVSGIEWATTNGMDV INMSLGGASGSTAMKQAVDNAYARGVVVVAAAGNSGNSGSTNTIGYPAKYDSVIAVGAVD SNSNRASFSSVGAELEVMAPGAGVYSTYPTNTYATLNGTSMASPHVAGAAALILSKHPNL SASQVRNRLSSTATYLGSSFYYGKGLINVEAAAQ
>1CSE_2 EGLIN C (chains I) TEFGSELKSFPEVVGKTVDQAREYFTLHYPQYNVYFLPEGSPVTLDLRYNRVRVFYNPGT NVVNHVPHVG
| ID | Name | Formula | Copies |
|---|---|---|---|
| CA | Calcium ion | Ca | 2 |
The high-resolution X-ray crystal structure of the complex formed between subtilisin Carlsberg and eglin c, an elastase inhibitor from the leech Hirudo medicinalis. Structural analysis, subtilisin structure and interface geometry. Bode, W., Papamokos, E., Musil, D. Eur J Biochem (1987) 166:673-692. DOI 10.1111/j.1432-1033.1987.tb13566.x · PubMed
Other PDB entries of the same protein (UniProt P00780 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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