1EQH: The 2.7 Å model of ovine cox-1

The 2.7 Å model of ovine cox-1 complexed with flurbiprofen. Determined by X-ray diffraction at 2.7 Å resolution. Released 11 Apr 2001.

Method

X-ray diffraction

Resolution

2.7 Å

Organism

Ovis aries

Chains

2

Atoms

9,530

Mol. weight

138 kDa

Ligands

NAG, BOG, HEM, FLP

Released

11 Apr 2001

Explore 1EQH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1EQH contains 91 α-helices and 60 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 45 helices, 31 β-strands

Molecules and chains

>1EQH_1 PROSTAGLANDIN H2 SYNTHASE-1 (chains A, B)
PVFSADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPEIWTWLRT
TLRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVRSNLIPSPPTYNIAHDYISWE
SFSNVSYYTRILPSVPRDCPTPMGTKGKKQLPDAEFLSRRFLLRRKFIPDPQGTNLMFAF
FAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQMLNGE
VYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATIWLREHNRVCDLLKAEH
PTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGAQFQYRNRIAME
FNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQPAGRIGGGRNI
DHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQELTGEKEMAAELEELYGDIDA
LEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKASTFGGEVGFNLVK
TATLKKLVCLNTKTCPYVSFHVPDPRQEDRPGVERPPTEL

Ligands and cofactors

Primary citation

Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations. Selinsky, B.S., Gupta, K., Sharkey, C.T. et al. Biochemistry (2001) 40:5172-5180. DOI 10.1021/bi010045s · PubMed

Related structures

Other PDB entries of the same protein (UniProt P05979 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 1Q4G 2.0 Å, 2.0 Angstrom Crystal Structure of Ovine Prostaglandin H2 Synthase-1, in complex with…
• 2AYL 2.0 Å, 2.0 Angstrom Crystal Structure of Manganese Protoporphyrin IX-reconstituted Ovine…
• 4O1Z 2.4 Å, Crystal Structure of Ovine Cyclooxygenase-1 Complex with Meloxicam
• 3N8Y 2.6 Å, Structure of Aspirin Acetylated Cyclooxygenase-1 in Complex with Diclofenac
• 1EQG 2.61 Å, The 2.6 Å model of ovine cox-1 complexed with ibuprofen
• 1HT8 2.69 Å, The 2.7 Å resolution model of ovine cox-1 complexed with alclofenac
• 2OYU 2.7 Å, Indomethacin-(S)-alpha-ethyl-ethanolamide bound to Cyclooxygenase-1
• 1HT5 2.75 Å, The 2.75 Å resolution model of ovine cox-1 complexed with methyl ester flurbiprofen
• 3KK6 2.75 Å, Crystal Structure of Cyclooxygenase-1 in complex with celecoxib
• 3N8W 2.75 Å, Crystal Structure of R120Q/Native Cyclooxygenase-1 Heterodimer mutant in complex with…
• 3N8X 2.75 Å, Crystal Structure of Cyclooxygenase-1 in Complex with Nimesulide
• 5WBE 2.75 Å, Cox-1:MOFEZOLAC complex structure

Browse structure collections

About this viewer

MolViewer shows 1EQH directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.