1FMD: Foot-and-mouth disease virus

Name: PDB 1FMD: The structure and antigenicity of a type C foot-and-mouth disease virus
Published: 1994-08-31
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: virus

The structure and antigenicity of a type C foot-and-mouth disease virus. Determined by X-ray diffraction at 3.5 Å resolution. Released 31 Aug 1994.

Method: X-ray diffraction
Resolution: 3.5 Å
Organism: Foot-and-mouth disease virus
Chains: 4
Atoms: 5,168
Mol. weight: 79.79 kDa
Released: 31 Aug 1994

Explore 1FMD in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1FMD contains 22 α-helices and 35 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 1: 7 helices, 8 β-strands

Element	Residues	Length	Sheet
α-helix	5-7	3
β-strand	11	1	1
α-helix	15-18	4
α-helix	27-30	4
α-helix	32-35	4
β-strand	39-42	4	2
β-strand	48-50	3	2
α-helix	53-55	3
α-helix	61-66	6
β-strand	69-89	21	2
α-helix	95-99	5
β-strand	105-106	2	2
β-strand	112-117	6	2
β-strand	126-127	2	2
β-strand	167-188	22	2

Chain 2: 5 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	16-19	4	3
β-strand	22-25	4	3
β-strand	33-34	2	4
α-helix	46-48	3
β-strand	53-54	2	4
β-strand	62-69	8	4
β-strand	78-82	5	5
α-helix	89-97	9
β-strand	98-112	15	4
β-strand	118-127	10	5
α-helix	135-137	3
β-strand	145-148	4	5
β-strand	155-160	6	4
β-strand	169	1	4
α-helix	171-173	3
β-strand	177-188	12	5
β-strand	197-213	17	4
α-helix	214-215	2

Chain 3: 6 helices, 13 β-strands

Element	Residues	Length	Sheet
α-helix	31-33	3
α-helix	44-50	7
α-helix	52	1
β-strand	53-54	2	6
α-helix	55	1
β-strand	65	1	7
β-strand	73-78	6	8
α-helix	90-95	6
β-strand	98-102	5	9
β-strand	105-111	7	6
β-strand	118-126	9	8
α-helix	136-139	4
β-strand	143-148	6	8
β-strand	156-159	4	6
β-strand	168-169	2	9
β-strand	183-192	10	8
β-strand	198	1	7
β-strand	199-205	7	6
β-strand	210-214	5	9

Chain 4: 4 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	23-24	2
α-helix	28-31	4
α-helix	33-35	3
α-helix	68-73	6
β-strand	76	1	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Foot-and-mouth disease virus (subunit VP1)	1	protein	208	Foot-and-mouth disease virus	Q65095
Foot-and-mouth disease virus (subunit VP2)	2	protein	218	Foot-and-mouth disease virus	P15072 (AlphaFold model)
Foot-and-mouth disease virus (subunit VP3)	3	protein	219	Foot-and-mouth disease virus	P15072 (AlphaFold model)
Foot-and-mouth disease virus (subunit VP4)	4	protein	85	Foot-and-mouth disease virus	P49303

Sequence of entity 1 (1), FASTA

>1FMD_1 FOOT-AND-MOUTH DISEASE VIRUS (SUBUNIT VP1) (chains 1)
TTTTGESADPVTTTVENYGGETQVQRRHHTDVAFVLDRFVKVTVSDNQHTLDVMQAHKDN
IVGALLRAATYYFSDLEIAVTHTGKLTWVPNGAPVSALNNTTNPTAYHKGPVTRLALPYT
APHRVLATAYTGTTTYTASARGDLAHLTTTHAAHLPTSFNFGAVKAETITELLVRMKRAE
LYCPRPILPIQPTGDRHKQPLVAPAKQL

Sequence of entity 2 (2), FASTA

>1FMD_2 FOOT-AND-MOUTH DISEASE VIRUS (SUBUNIT VP2) (chains 2)
DKKTEETTLLEDRILTTRNGHTTSTTQSSVGVTFGYATAEDSTSGPNTSALETRVHQAER
FFKMALFDWVPSQNFGHMHKVVLPHEPKGVYGGLVKSYAYMRNGWDVEVTAVGNQFNGGC
LLVALVPEMGDISDREKYQLTLYPHQFINPRTNMTAHITVPYVGVNRYDQYKQHRPWTLV
VMVVAPLTTNTAGAQQIKVYANIAPTNVHVAGELPSKE

Sequence of entity 3 (3), FASTA

>1FMD_3 FOOT-AND-MOUTH DISEASE VIRUS (SUBUNIT VP3) (chains 3)
GIFPVACSDGYGNMVTTDPKTADPAYGKVYNPPRTALPGRFTNYLDVAEACPTFLMFENV
PYVSTRTDGQRLLAKFDVSLAAKHMSNTYLAGLAQYYTQYTGTINLHFMFTGPTDAKARY
MVAYVPPGMDAPDNPEEAAHCIHAEWDTGLNSKFTFSIPYISAADYTYTASHEAETTCVQ
GWVCVYQITHGKADADALVVSASAGKDFELRLPVDARQQ

Sequence of entity 4 (4), FASTA

>1FMD_4 FOOT-AND-MOUTH DISEASE VIRUS (SUBUNIT VP4) (chains 4)
GAGQSSPATGSQNQSGNTGSIINNYYMQQYQNSMDTQLGDNAISGGSNEGSTDTTSTHTT
NTQNNDWFSKLASSAFSGLFGALLA

Primary citation

The structure and antigenicity of a type C foot-and-mouth disease virus. Lea, S., Hernandez, J., Blakemore, W. et al. Structure (1994) 2:123-139. DOI 10.1016/S0969-2126(00)00014-9 · PubMed

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