1I50: RNA polymerase II crystal form II

RNA polymerase II crystal form II at 2.8 a resolution. Determined by X-ray diffraction at 2.8 Å resolution. Released 23 Apr 2001.

Method
X-ray diffraction
Resolution
2.8 Å
Organism
Saccharomyces cerevisiae
Chains
10
Atoms
28,366
Mol. weight
470.2 kDa
Ligands
MN, ZN
Released
23 Apr 2001

Explore 1I50 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1I50 contains 164 α-helices and 198 β-strands across 10 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 72 helices, 70 β-strands

ElementResiduesLengthSheet
α-helix101
β-strand1111
β-strand16-1832
β-strand2113
α-helix24-307
β-strand4314
β-strand4614
β-strand8215
β-strand85-9176
α-helix93-953
α-helix96-1038
β-strand10617
β-strand11317
α-helix120-1278
α-helix133-14210
β-strand14718
β-strand151-15339
β-strand161-16339
β-strand17018
α-helix171-1722
β-strand173-177510
β-strand180-185610
β-strand198-202510
α-helix2031
α-helix204-2118
α-helix216-2216
β-strand225111
β-strand229111
α-helix231-2344
β-strand235-23846
β-strand24115
α-helix261-27717
α-helix286-30419
α-helix325-3295
β-strand348-355812
β-strand363-367512
α-helix368-3714
β-strand375-379513
α-helix385-39410
β-strand402-406513
β-strand412-414313
β-strand431-435513
α-helix4361
β-strand441-445512
α-helix452-4543
β-strand455-463912
β-strand468-470312
α-helix472-4743
α-helix475-4784
β-strand486-490512
α-helix495-5006
α-helix501-5055
β-strand506112
α-helix507-5104
β-strand512-513214
β-strand518-519214
α-helix525-53511
β-strand540-542315
α-helix543-55210
α-helix561-5633
β-strand565115
β-strand571-573315
α-helix574-5818
α-helix5831
β-strand588-590316
β-strand605-607316
β-strand612-614316
α-helix619-6224
α-helix629-6379
α-helix639-65820
α-helix666-6694
α-helix673-69927
α-helix702-7054
α-helix710-73627
α-helix742-7498
α-helix755-7628
β-strand766-767217
β-strand770118
β-strand773118
α-helix775-7762
β-strand779119
β-strand782119
β-strand799-800217
α-helix810-84536
β-strand849-850220
β-strand856-857220
β-strand863-865320
α-helix868-8703
β-strand873121
α-helix875-8773
β-strand878-882522
α-helix884-8863
α-helix890-8978
β-strand913123
α-helix914-9196
α-helix923-94624
β-strand953-957522
α-helix960-97011
α-helix9781
β-strand979123
α-helix983-99412
α-helix1005-101410
α-helix1016-102510
α-helix1028-10292
α-helix1030-10356
α-helix1039-105416
β-strand1057121
α-helix1058-10592
α-helix1064-107310
α-helix1075-10773
α-helix1097-110610
β-strand1116-1119424
β-strand1120125
α-helix1128-113811
β-strand1141-1142226
α-helix1143-11453
β-strand1147-1154827
α-helix1164-11663
α-helix1167-11715
β-strand1191-1197727
α-helix1199-12046
α-helix1209-12179
β-strand1224-1228527
β-strand1236-1242727
α-helix1256-126510
α-helix1266-12705
β-strand1272-1274326
β-strand1282-1287624
β-strand1290-1292328
β-strand1298-1300328
β-strand1303-1308624
α-helix1313-13175
β-strand1322125
β-strand1328-1329224
α-helix1332-13398
α-helix1341-135717
α-helix1365-137410
α-helix1405-141511
β-strand1418-141922
α-helix1424-14296
α-helix1437-14393
β-strand1442-1445429
Chain B: 49 helices, 68 β-strands
ElementResiduesLengthSheet
β-strand24130
α-helix251
α-helix27-293
α-helix30-4112
α-helix45-539
α-helix54-585
α-helix59-624
β-strand68131
β-strand91-1001031
β-strand101-102232
α-helix108-1092
β-strand110-111232
α-helix114-1196
β-strand125-133931
β-strand166-171631
α-helix172-1732
α-helix186-1916
β-strand203-205333
β-strand208-212533
β-strand214-218534
β-strand224-227435
β-strand234-241835
β-strand253-259735
β-strand269-272435
β-strand280-281235
α-helix282-2887
α-helix294-3018
α-helix308-31912
α-helix327-33610
α-helix345-35814
α-helix371-38919
α-helix394-3963
α-helix401-4033
β-strand404-407434
α-helix409-42921
α-helix451-46313
β-strand480-482333
α-helix483-4842
α-helix488-4947
β-strand497-499334
α-helix516-5183
β-strand522136
β-strand536-538334
β-strand539136
β-strand544-545237
α-helix552-5609
β-strand564-565238
α-helix566-5683
α-helix571-5733
β-strand578-582538
β-strand585-590638
α-helix593-60614
β-strand614-618538
β-strand623-627538
β-strand633-639737
β-strand654130
α-helix655-66612
α-helix681-6866
β-strand690-694537
α-helix695-6984
β-strand703-704237
α-helix707-7104
β-strand740-741237
α-helix745-7484
α-helix753-7553
α-helix759-7613
β-strand762139
α-helix764-77310
α-helix774-7763
β-strand777140
β-strand779141
β-strand792-796541
β-strand800142
β-strand804-805243
α-helix808-8103
β-strand821-827744
β-strand838-842544
α-helix843-8475
β-strand853-861941
β-strand873145
β-strand898145
β-strand904141
β-strand910-916745
β-strand935-940645
α-helix941-9422
β-strand948-956941
β-strand962-9721141
β-strand979-981344
β-strand987-994844
α-helix996-9983
β-strand1001-1002246
β-strand1010-1012344
α-helix1014-10163
β-strand1022139
α-helix1023-103816
β-strand1042-1043243
α-helix1052-106110
β-strand1069-1070244
β-strand1072-1073246
α-helix10791
β-strand1080146
α-helix10811
β-strand1085-10941044
β-strand1095140
α-helix1099-11013
β-strand1105-1106212
α-helix1132-11409
α-helix1144-11518
β-strand1157-116371
β-strand1172-1174347
β-strand1179-1181347
β-strand1182148
β-strand1187148
β-strand1191-119771
α-helix1198-120912
β-strand121213
β-strand1215-121732
Chain C: 13 helices, 13 β-strands
ElementResiduesLengthSheet
β-strand7149
β-strand17-22650
β-strand23149
α-helix27-3913
β-strand43-541251
α-helix60-6910
β-strand72-74352
α-helix77-793
β-strand97-104851
α-helix1101
β-strand111-114453
α-helix115-1173
β-strand119-120251
β-strand129-132452
α-helix1331
β-strand143-147553
β-strand152-1621151
α-helix168-1703
β-strand173-180850
α-helix197-2004
α-helix202-2043
α-helix205-2073
α-helix211-2144
α-helix217-2193
β-strand228-234750
α-helix240-26324
Chain E: 14 helices, 14 β-strands
ElementResiduesLengthSheet
α-helix3-2624
β-strand28154
α-helix32-354
α-helix39-468
β-strand47155
β-strand53155
α-helix55-573
β-strand60-62356
β-strand64154
α-helix66-694
β-strand78-82556
β-strand87-88257
α-helix90-10213
β-strand107-112656
β-strand115-116257
α-helix118-1214
β-strand131-136656
α-helix137-1404
α-helix144-1463
α-helix1511
β-strand152-155458
α-helix156-1572
α-helix158-16710
α-helix172-1743
β-strand177-178258
α-helix183-1886
β-strand195-201758
β-strand207-214858
Chain F: 4 helices, 4 β-strands
ElementResiduesLengthSheet
β-strand84159
α-helix85-862
α-helix87-10216
α-helix105-1073
α-helix117-12610
β-strand132-137629
β-strand143-147529
β-strand152159
Chain H: 3 helices, 9 β-strands
ElementResiduesLengthSheet
β-strand9-16815
β-strand23-30815
β-strand37-43715
α-helix44-463
β-strand54-58515
α-helix83-864
β-strand95-98415
β-strand100-101215
β-strand112-118715
β-strand121-127715
α-helix129-1324
β-strand141-145515
Chain I: 1 helix, 10 β-strands
ElementResiduesLengthSheet
β-strand6160
β-strand13160
β-strand15-19561
β-strand24-28561
β-strand35-37361
β-strand42-47627
α-helix60-645
β-strand70-71262
β-strand83-87562
β-strand99-103562
β-strand109-111362
Chain J: 4 helices, 3 β-strands
ElementResiduesLengthSheet
β-strand6163
β-strand13163
α-helix18-258
α-helix32-387
α-helix44-529
β-strand53142
α-helix57-604

2 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
DNA-directed RNA polymerase II largest subunitAprotein1733Saccharomyces cerevisiaeP04050 (AlphaFold model)
DNA-directed RNA polymerase II 140KD polypeptideBprotein1224Saccharomyces cerevisiaeP08518 (AlphaFold model)
DNA-directed RNA polymerase II 45KD polypeptideCprotein318Saccharomyces cerevisiaeP16370 (AlphaFold model)
DNA-directed RNA polymerase II 27KD polypeptideEprotein215Saccharomyces cerevisiaeP20434 (AlphaFold model)
DNA-directed RNA polymerase II 23KD polypeptideFprotein155Saccharomyces cerevisiaeP20435
DNA-directed RNA polymerase II 14.5KD polypeptideHprotein146Saccharomyces cerevisiaeP20436
DNA-directed RNA polymerase II 14.2KD polypeptideIprotein122Saccharomyces cerevisiaeP27999
DNA-directed RNA polymerase II 8.3KD polypeptideJprotein70Saccharomyces cerevisiaeP22139
DNA-directed RNA polymerase II 13.6KD polypeptideKprotein120Saccharomyces cerevisiaeP38902
DNA-directed RNA polymerase II 7.7KD polypeptideLprotein70Saccharomyces cerevisiaeP40422
Sequence of entity 1 (A), FASTA
>1I50_1 DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT (chains A)
MVGQQYSSAPLRTVKEVQFGLFSPEEVRAISVAKIRFPETMDETQTRAKIGGLNDPRLGS
IDRNLKCQTCQEGMNECPGHFGHIDLAKPVFHVGFIAKIKKVCECVCMHCGKLLLDEHNE
LMRQALAIKDSKKRFAAIWTLCKTKMVCETDVPSEDDPTQLVSRGGCGNTQPTIRKDGLK
LVGSWKKDRATGDADEPELRVLSTEEILNIFKHISVKDFTSLGFNEVFSRPEWMILTCLP
VPPPPVRPSISFNESQRGEDDLTFKLADILKANISLETLEHNGAPHHAIEEAESLLQFHV
ATYMDNDIAGQPQALQKSGRPVKSIRARLKGKEGRIRGNLMGKRVDFSARTVISGDPNLE
LDQVGVPKSIAKTLTYPEVVTPYNIDRLTQLVRNGPNEHPGAKYVIRDSGDRIDLRYSKR
AGDIQLQYGWKVERHIMDNDPVLFNRQPSLHKMSMMAHRVKVIPYSTFRLNLSVTSPYNA
DFDGDEMNLHVPQSEETRAELSQLCAVPLQIVSPQSNKPCMGIVQDTLCGIRKLTLRDTF
IELDQVLNMLYWVPDWDGVIPTPAIIKPKPLWSGKQILSVAIPNGIHLQRFDEGTTLLSP
KDNGMLIIDGQIIFGVVEKKTVGSSNGGLIHVVTREKGPQVCAKLFGNIQKVVNFWLLHN
GFSTGIGDTIADGPTMREITETIAEAKKKVLDVTKEAQANLLTAKHGMTLRESFEDNVVR
FLNEARDKAGRLAEVNLKDLNNVKQMVMAGSKGSFINIAQMSACVGQQSVEGKRIAFGFV
DRTLPHFSKDDYSPESKGFVENSYLRGLTPQEFFFHAMGGREGLIDTAVKTAETGYIQRR
LVKALEDIMVHYDNTTRNSLGNVIQFIYGEDGMDAAHIEKQSLDTIGGSDAAFEKRYRVD
LLNTDHTLDPSLLESGSEILGDLKLQVLLDEEYKQLVKDRKFLREVFVDGEANWPLPVNI
RRIIQNAQQTFHIDHTKPSDLTIKDIVLGVKDLQENLLVLRGKNEIIQNAQRDAVTLFCC
LLRSRLATRRVLQEYRLTKQAFDWVLSNIEAQFLRSVVHPGEMVGVLAAQSIGEPATQMT
LNTFHFAGVASKKVTSGVPRLKEILNVAKNMKTPSLTVYLEPGHAADQEQAKLIRSAIEH
TTLKSVTIASEIYYDPDPRSTVIPEDEEIIQLHFSLLDEEAEQSFDQQSPWLLRLELDRA
AMNDKDLTMGQVGERIKQTFKNDLFVIWSEDNDEKLIIRCRVVRPKSLDAETEAEEDHML
KKIENTMLENITLRGVENIERVVMMKYDRKVPSPTGEYVKEPEWVLETDGVNLSEVMTVP
GIDPTRIYTNSFIDIMEVLGIEAGRAALYKEVYNVIASDGSYVNYRHMALLVDVMTTQGG
LTSVTRHGFNRSNTGALMRCSFEETVEILFEAGASAELDDCRGVSENVILGQMAPIGTGA
FDVMIDEESLVKYMPEQKITEIEDGQDGGVTPYSNESGLVNADLDVKDELMFSPLVDSGS
NDAMAGGFTAYGGADYGEATSPFGAYGEAPTSPGFGVSSPGFSPTSPTYSPTSPAYSPTS
PSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYS
PTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPAYSPTSPSYSPTSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPGYSPGSPAYSPKQDEQKHNENENSR
Sequence of entity 2 (B), FASTA
>1I50_2 DNA-DIRECTED RNA POLYMERASE II 140KD POLYPEPTIDE (chains B)
MSDLANSEKYYDEDPYGFEDESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYTLQ
DIICEDSTLILEQLAQHTTESDNISRKYEISFGKIYVTKPMVNESDGVTHALYPQEARLR
NLTYSSGLFVDVKKRTYEAIDVPGRELKYELIAEESEDDSESGKVFIGRLPIMLRSKNCY
LSEATESDLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEI
RSALEKGSRFISTLQVKLYGREGSSARTIKATLPYIKQDIPIVIIFRALGIIPDGEILEH
ICYDVNDWQMLEMLKPCVEDGFVIQDRETALDFIGRRGTALGIKKEKRIQYAKDILQKEF
LPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTL
FKKLTKDIFRYMQRTVEEAHDFNMKLAINAKTITSGLKYALATGNWGEQKKAMSSRAGVS
QVLNRYTYSSTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLS
LMSCISVGTDPMPIITFLSEWGMEPLEDYVPHQSPDATRVFVNGVWHGVHRNPARLMETL
RTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDESLGHKELKVRKGHIAK
LMATEYQDIEGGFEDVEEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPAEANEEND
LDVDPAKRIRVSHHATTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGV
FLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMI
MNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPQRTNTLRMKHGTYDKLDDDGLIA
PGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQDG
LKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSR
MTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQSRGFEVMYNGHTGKK
LMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIA
HGAASFLKERLMEASDAFRVHICGICGLMTVIAKLNHNQFECKGCDNKIDIYQIHIPYAA
KLLFQELMAMNITPRLYTDRSRDF
Sequence of entity 3 (C), FASTA
>1I50_3 DNA-DIRECTED RNA POLYMERASE II 45KD POLYPEPTIDE (chains C)
MSEEGPQVKIREASKDNVDFILSNVDLAMANSLRRVMIAEIPTLAIDSVEVETNTTVLAD
EFIAHRLGLIPLQSMDIEQLEYSRDCFCEDHCDKCSVVLTLQAFGESESTTNVYSKDLVI
VSNLMGRNIGHPIIQDKEGNGVLICKLRKGQELKLTCVAKKGIAKEHAKWGPAAAIEFEY
DPWNKLKHTDYWYEQDSAKEWPQSKNCEYEDPPNEGDPFDYKAQADTFYMNVESVGSIPV
DQVVVRGIDTLQKKVASILLALTQMDQDKVNFASGDNNTASNMLGSNEDVMMTGAEQDPY
SNASQMGNTGSGGYDNAW
Sequence of entity 4 (E), FASTA
>1I50_4 DNA-DIRECTED RNA POLYMERASE II 27KD POLYPEPTIDE (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM
Sequence of entity 5 (F), FASTA
>1I50_5 DNA-DIRECTED RNA POLYMERASE II 23KD POLYPEPTIDE (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL
Sequence of entity 6 (H), FASTA
>1I50_6 DNA-DIRECTED RNA POLYMERASE II 14.5KD POLYPEPTIDE (chains H)
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIA
SSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGG
LLMRLEGNYRNLNNLKQENAYLLIRR
Sequence of entity 7 (I), FASTA
>1I50_7 DNA-DIRECTED RNA POLYMERASE II 14.2KD POLYPEPTIDE (chains I)
MTTFRFCRDCNNMLYPREDKENNRLLFECRTCSYVEEAGSPLVYRHELITNIGETAGVVQ
DIGSDPTLPRSDRECPKCHSRENVFFQSQQRRKDTSMVLFFVCLSCSHIFTSDQKNKRTQ
FS
Sequence of entity 8 (J), FASTA
>1I50_8 DNA-DIRECTED RNA POLYMERASE II 8.3KD POLYPEPTIDE (chains J)
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKF
LRYNPLEKRD
Sequence of entity 9 (K), FASTA
>1I50_9 DNA-DIRECTED RNA POLYMERASE II 13.6KD POLYPEPTIDE (chains K)
MNAPDRFELFLLGEGESKLKIDPDTKAPNAVVITFEKEDHTLGNLIRAELLNDRKVLFAA
YKVEHPFFARFKLRIQTTEGYDPKDALKNACNSIINKLGALKTNFETEWNLQTLAADDAF
Sequence of entity 10 (L), FASTA
>1I50_10 DNA-DIRECTED RNA POLYMERASE II 7.7KD POLYPEPTIDE (chains L)
MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKAR
TKRLVQFEAR

Ligands and cofactors

IDNameFormulaCopies
MNManganese (II) ionMn1
ZNZinc ionZn8

Primary citation

Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. Cramer, P., Bushnell, D.A., Kornberg, R.D. Science (2001) 292:1863-1876. DOI 10.1126/science.1059493 · PubMed

Other PDB entries of the same protein (UniProt P04050 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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1I50 is part of these collections:

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