1IBR: Complex of ran with importin beta

Complex of ran with importin beta. Determined by X-ray diffraction at 2.3 Å resolution. Released 3 Jun 1999.

Method: X-ray diffraction
Resolution: 2.3 Å
Organism: Homo sapiens
Chains: 4
Atoms: 10,117
Mol. weight: 152.95 kDa
Ligands: GNP, MG
Released: 3 Jun 1999

Explore 1IBR in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1IBR contains 71 α-helices and 14 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	10-17	8	1
α-helix	23-32	10
β-strand	45-52	8	1
β-strand	55	1	2
β-strand	57	1	2
β-strand	59-66	8	1
α-helix	70-72	3
α-helix	76-80	5
β-strand	85-91	7	1
α-helix	95-99	5
α-helix	101-109	9
β-strand	117-122	6	1
α-helix	133-135	3
α-helix	138-142	5
β-strand	145-148	4	1
α-helix	159-169	11

Chain B: 28 helices, 0 β-strands

Element	Residues	Length
α-helix	3-9	7
α-helix	15-45	31
α-helix	51-65	15
α-helix	70-81	12
α-helix	85-98	14
α-helix	109-120	12
α-helix	121-123	3
α-helix	129-138	10
α-helix	144-160	17
α-helix	163-165	3
α-helix	167-169	3
α-helix	170-181	12
α-helix	188-201	14
α-helix	206-209	4
α-helix	212-225	14
α-helix	231-247	17
α-helix	249-251	3
α-helix	260-269	10
α-helix	273-297	25
α-helix	314-329	16
α-helix	344-358	15
α-helix	363-374	12
α-helix	380-392	13
α-helix	409-415	7
α-helix	416-418	3
α-helix	422-438	17
α-helix	439-442	4
α-helix	449-457	9

Chain C: 8 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	10-17	8	3
α-helix	23-31	9
β-strand	45-52	8	3
β-strand	59-66	8	3
α-helix	70-72	3
α-helix	76-80	5
β-strand	85-91	7	3
α-helix	95-99	5
α-helix	101-109	9
β-strand	117-122	6	3
α-helix	133-135	3
α-helix	138-142	5
β-strand	145-148	4	3
α-helix	159-169	11

Chain D: 27 helices, 0 β-strands

Element	Residues	Length
α-helix	3-9	7
α-helix	15-31	17
α-helix	33-45	13
α-helix	51-65	15
α-helix	70-81	12
α-helix	85-98	14
α-helix	109-120	12
α-helix	121-123	3
α-helix	129-138	10
α-helix	144-160	17
α-helix	163-165	3
α-helix	167-169	3
α-helix	170-181	12
α-helix	188-201	14
α-helix	206-209	4
α-helix	212-225	14
α-helix	231-247	17
α-helix	249-251	3
α-helix	260-269	10
α-helix	273-298	26
α-helix	314-329	16
α-helix	344-358	15
α-helix	363-374	12
α-helix	380-392	13
α-helix	403-415	13
α-helix	416-418	3
α-helix	422-437	16

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
GTP-binding nuclear protein RAN	A, C	protein	216	Homo sapiens	P62826 (AlphaFold model)
Importin beta-1 subunit	B, D	protein	462	Homo sapiens	Q14974 (AlphaFold model)

Sequence of entity 1 (A, C), FASTA

>1IBR_1 GTP-binding nuclear protein RAN (chains A, C)
MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIK
FNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLC
GNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMP
ALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL

Sequence of entity 2 (B, D), FASTA

>1IBR_2 Importin beta-1 subunit (chains B, D)
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQ
IKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE
IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQG
MRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQN
LVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEA
AEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE
DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDP
SVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSA

Ligands and cofactors

ID	Name	Formula	Copies
GNP	Phosphoaminophosphonic acid-guanylate ester	C10 H17 N6 O13 P3	2
MG	Magnesium ion	Mg	2

Primary citation

Structural view of the Ran-Importin beta interaction at 2.3 A resolution. Vetter, I.R., Arndt, A., Kutay, U. et al. Cell (1999) 97:635-646. DOI 10.1016/S0092-8674(00)80774-6 · PubMed

Other PDB entries of the same protein (UniProt P62826 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3GJ0 1.48 Å, Crystal structure of human RanGDP
7MO5 1.55 Å, Crystal Structure of the ZnF4 of Nucleoporin NUP153 in complex with Ran-GDP
7MO1 1.6 Å, Crystal Structure of the ZnF1 of Nucleoporin NUP153 in complex with Ran-GDP
5CIQ 1.65 Å, Ran GDP wild type tetragonal crystal form
7MO2 1.65 Å, Crystal Structure of the ZnF2 of Nucleoporin NUP153 in complex with Ran-GDP
5CIT 1.75 Å, Ran GDP wild type monoclinic crystal form
5CIW 1.75 Å, Ran GDP Y39A mutant monoclinic crystal form
5CJ2 1.75 Å, Ran GDP Y39A mutant triclinic crystal form
1I2M 1.76 Å, Ran-RCC1-SO4 complex
4HAT 1.78 Å, Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1-Ran-RanBP1
3GJ3 1.79 Å, Crystal structure of human RanGDP-Nup153ZnF2 complex
3GJ5 1.79 Å, Crystal structure of human RanGDP-Nup153ZnF4 complex

Browse structure collections

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