1IGA: IGA1

Model of human IGA1 determined by solution scattering curve-fitting and homology modelling. Determined by solution scattering. Released 15 Jun 1999.

Method

Solution scattering

Organism

Homo sapiens

Chains

4

Atoms

1,378

Mol. weight

148.57 kDa

Released

15 Jun 1999

Explore 1IGA in 3D Show helices and sheets RCSB PDB PDBe

Molecules and chains

>1IGA_1 IGA1 (chains A, B)
QVKLLEQSGAEVKKPGASVKVSCKASGYSFTSYGLHWVRQAPGQRLEWMGWISAGTGNTK
YSQKFRGRVTFTRDTSATTAYMGLSSLRPEDTAVYYCARDPYGGGKSEFDYWGQGTLVTV
SSASPTSPKVFPLSLCSTQPDGNVVIACLVQGFFPQEPLSVTWSESGQGVTARNFPPSQD
ASGDLYTTSSQLTLPATQCLAGKSVTCHVKHYTNPSQDVTVPCPVPSTPPTPSPSTPPTP
SPSCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERD
LCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKSGNTFRPEVHLLPPPSE
ELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSIL
RVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMAEVDGTCY

>1IGA_2 IGA1 (chains C, D)
ELVMTQSPSSLSASVGDRVNIACRASQGISSALAWYQQKPGKAPRLLIYDASNLESGVPS
RFSGSGSGTDFTLTISSLQPEDFAIYYCQQFNSYPLTFGGGTKVEIKRTVAAPSVFIFPP
SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLT
LSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

Primary citation

The Fab and Fc fragments of IgA1 exhibit a different arrangement from that in IgG: a study by X-ray and neutron solution scattering and homology modelling. Boehm, M.K., Woof, J.M., Kerr, M.A. et al. J Mol Biol (1999) 286:1421-1447. DOI 10.1006/jmbi.1998.2556 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P01876 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 9R2E 2.54 Å, Structure of ARGX-121 Fab fragment in complex with the Fc fragment of IgA1
• 9OFR 2.65 Å, Crystal structure of the human IGA1 fc fragment-fc-alpha receptor (CD89) complex
• 6UE7 2.9 Å, Structure of dimeric sIgA complex
• 1OW0 3.1 Å, Crystal structure of human FcaRI bound to IgA1-Fc
• 8SKV 3.1 Å, Structure of human SIgA1 in complex with Streptococcus pyogenes protein M4 (Arp4)
• 6LX3 3.15 Å, Cryo-EM structure of human secretory immunoglobulin A
• 2QEJ 3.2 Å, Crystal structure of a Staphylococcus aureus protein (SSL7) in complex with Fc of human…
• 8SKU 3.2 Å, Structure of human SIgA1 in complex with human CD89 (FcaR1)
• 6LXW 3.27 Å, Cryo-EM structure of human secretory immunoglobulin A in complex with the N-terminal…
• 9MBZ 3.3 Å, Cryo-EM structure of human FcRL4 bound to IgA-Fc/J
• 7UVL 3.56 Å, IgA1 Protease with IgA1 substrate
• 6XJA 4.0 Å, Streptococcus Pneumoniae IgA1 Protease with IgA1 substrate

Browse structure collections

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