1JRH: Complex

Name: PDB 1JRH: Complex (antibody/antigen)
Published: 1998-03-25
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: complex (antibody/antigen)

Complex (antibody/antigen). Determined by X-ray diffraction at 2.8 Å resolution. Released 25 Mar 1998.

Method: X-ray diffraction
Resolution: 2.8 Å
Organisms: Mus musculus, Homo sapiens
Chains: 3
Atoms: 3,465
Mol. weight: 59.28 kDa
Released: 25 Mar 1998

Explore 1JRH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1JRH contains 11 α-helices and 52 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain H: 5 helices, 21 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	7
β-strand	11-12	2	8
β-strand	18-25	8	7
β-strand	35-39	7	9
β-strand	46-52	7	9
β-strand	57-59	3	9
α-helix	64-66	3
β-strand	67-72	6	7
β-strand	77-82	6	7
α-helix	84-86	3
β-strand	88-95	8	9
α-helix	96	1
β-strand	100D-103	4	9
β-strand	107-109	3	9
β-strand	110-111	2	8
β-strand	143	1	10
β-strand	153-156	3	11
β-strand	171-173	3	12
α-helix	174-176	3
β-strand	177-178	2	13
β-strand	185-186	2	13
β-strand	188	1	10
β-strand	189-191	3	12
β-strand	209-212	4	11
α-helix	213-215	3
β-strand	217-219	3	11

Chain I: 3 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	12-15	4
β-strand	16-21	6	14
β-strand	28-32	5	14
β-strand	41-49	9	15
β-strand	53	1	15
β-strand	57-63	7	15
β-strand	67-69	3	14
α-helix	71-73	3
β-strand	80-89	10	15
β-strand	92-93	2	15
α-helix	94-96	3
β-strand	97-98	2	15
β-strand	102	1	15

Chain L: 3 helices, 21 β-strands

Element	Residues	Length	Sheet
β-strand	4-7	4	1
β-strand	10-13	4	2
β-strand	19-25	7	1
β-strand	33-38	6	2
β-strand	45-49	5	2
β-strand	53-54	2	2
α-helix	55	1
β-strand	62-67	6	1
β-strand	70-75	6	1
α-helix	80-82	3
β-strand	85-90	6	2
β-strand	97-98	2	2
β-strand	102-106	5	2
β-strand	111	1	3
β-strand	114-116	3	4
β-strand	135-139	5	4
β-strand	140	1	3
β-strand	145-146	2	5
β-strand	162-163	2	4
α-helix	164-167	4
β-strand	173-176	4	4
β-strand	195	1	6
β-strand	196-197	2	5
β-strand	206	1	6

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Antibody A6	L	protein	213	Mus musculus	P01837 (AlphaFold model)
Antibody A6	H	protein	219	Mus musculus	P01869 (AlphaFold model)
Interferon-gamma receptor alpha chain	I	protein	108	Homo sapiens	P15260 (AlphaFold model)

Sequence of entity 1 (L), FASTA

>1JRH_1 ANTIBODY A6 (chains L)
SVEMTQSPSSFSVSLGDRVTITCKASEDIYNRLAWYQQKPGNAPRLLISGATSLETEVPS
RFSGSGSGKDYTLSITSLQTEDVATYYCQQYWSTWTFGGGTKLEIKRADAAPTVSIFPPS
SEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTL
TKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC

Sequence of entity 2 (H), FASTA

>1JRH_2 ANTIBODY A6 (chains H)
AVKLQESGPGILKPSQTLSLTCSFSGFSLTTYGMGVGWIRQSSGKGLEWLAHIWWDDDKY
YNPSLKSRLTISKDTSRNQVFLKITSVATADTATYYCARRAPFYGNHAMDYWGQGTTVTV
SSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQ
SDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKI

Sequence of entity 3 (I), FASTA

>1JRH_3 INTERFERON-GAMMA RECEPTOR ALPHA CHAIN (chains I)
EMGTADLGPSSVPTPTNVTIESYNMNPIVYWEYQIMPQVPVFTVEVKNYGVKNSEWIDAC
INISHHYCNISDHVGDPSNSLWVRVKARVGQKESAYAKSEEFAVSRDG

Primary citation

Neutralizing epitopes on the extracellular interferon gamma receptor (IFNgammaR) alpha-chain characterized by homolog scanning mutagenesis and X-ray crystal structure of the A6 fab-IFNgammaR1-108 complex. Sogabe, S., Stuart, F., Henke, C. et al. J Mol Biol (1997) 273:882-897. DOI 10.1006/jmbi.1997.1336 · PubMed

Other PDB entries of the same protein (UniProt P01837 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3D9A 1.2 Å, High Resolution Crystal Structure Structure of HyHel10 Fab Complexed to Hen Egg Lysozyme
1RUR 1.5 Å, Crystal Structure (I) of native Diels-Alder antibody 13G5 Fab at pH 8.0 with a data set…
2AJU 1.5 Å, Cyrstal structure of cocaine catalytic antibody 7A1 Fab'
2AJV 1.5 Å, Crystal Structure of Cocaine catalytic Antibody 7A1 Fab' in Complex with Cocaine
2W60 1.5 Å, Anti citrullinated Collagen type 2 antibody acc4
2W9D 1.57 Å, Structure of Fab fragment of the ICSM 18 - anti-Prp therapeutic antibody at 1.57 A…
3BKJ 1.59 Å, Crystal structure of Fab wo2 bound to the n terminal domain of amyloid beta peptide (1-16)
3BAE 1.59 Å, Crystal structure of Fab WO2 bound to the N terminal domain of Amyloid beta peptide (1-28)
2R1Y 1.6 Å, Crystal structure of S25-2 Fab in complex with Kdo analogues
2R2B 1.6 Å, Crystal structure of S25-2 Fab in complex with Kdo analogues
3BKM 1.6 Å, Structure of anti-amyloid-beta Fab WO2 (Form A, P212121)
3CFB 1.6 Å, High-resolution structure of blue fluorescent antibody EP2-19G2 in complex with stilbene…

Browse structure collections

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