1KAZ: 70KD heat shock cognate protein

70KD heat shock cognate protein atpase domain, K71E mutant. Determined by X-ray diffraction at 1.7 Å resolution. Released 8 Nov 1996.

Method: X-ray diffraction
Resolution: 1.7 Å
Organism: Bos taurus
Chains: 1
Atoms: 3,381
Mol. weight: 42.72 kDa
Ligands: MG, ATP
Released: 8 Nov 1996

Explore 1KAZ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1KAZ contains 17 α-helices and 19 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 17 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	7-11	5	1
β-strand	15-22	8	1
β-strand	25-28	4	1
α-helix	29-30	2
β-strand	38-39	2	1
β-strand	42-44	3	2
β-strand	49-51	3	2
α-helix	53-56	4
α-helix	63-65	3
β-strand	66-67	2	2
α-helix	70-72	3
α-helix	81-87	7
β-strand	93-97	5	3
β-strand	100-107	8	3
β-strand	110-114	5	3
α-helix	116-135	20
β-strand	141-146	6	1
α-helix	152-164	13
β-strand	168-174	7	1
α-helix	175-182	8
β-strand	193-200	8	4
β-strand	205-213	9	4
β-strand	216-225	10	4
α-helix	230-249	20
α-helix	257-273	17
β-strand	279-288	10	5
β-strand	291-298	8	5
α-helix	299-312	14
α-helix	314-324	11
α-helix	328-330	3
β-strand	333-337	5	4
α-helix	339-342	4
α-helix	344-353	10
α-helix	357-359	3
β-strand	360	1	4
α-helix	368-380	13

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
70KD heat shock cognate protein	A	protein	381	Bos taurus	P19120 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1KAZ_1 70KD HEAT SHOCK COGNATE PROTEIN (chains A)
MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVA
MNPTNTVFDAERLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVS
SMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAA
IAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNH
FIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRA
RFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELN
KSINPDEAVAYGAAVQAAILS

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	1
ATP	Adenosine-5'-triphosphate	C10 H16 N5 O13 P3	1

Water and common crystallization additives (K, CL) are not listed.

Primary citation

Lysine 71 of the chaperone protein Hsc70 Is essential for ATP hydrolysis. O'Brien, M.C., Flaherty, K.M., McKay, D.B. J Biol Chem (1996) 271:15874-15878. DOI 10.1074/jbc.271.27.15874 · PubMed

Other PDB entries of the same protein (UniProt P19120 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7ODB 1.66 Å, Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with triazine-derivative
1BA1 1.7 Å, Heat-shock cognate 70KD protein 44KD atpase N-terminal mutant with cys 17 replaced by lys
1BUP 1.7 Å, T13S mutant of bovine 70 kilodalton heat shock protein
1HPM 1.7 Å, How potassium affects the activity of the molecular chaperone HSC70. II. Potassium binds…
1KAX 1.7 Å, 70KD heat shock cognate protein atpase domain, K71M mutant
1KAY 1.7 Å, 70KD heat shock cognate protein atpase domain, K71A mutant
2BUP 1.7 Å, T13G Mutant of the ATPASE fragment of Bovine HSC70
2QWO 1.7 Å, Crystal structure of disulfide-bond-crosslinked complex of bovine hsc70 (1-394aa)R171C…
2QWL 1.75 Å, Crystal structure of bovine hsc70 (1-394aa)in the ADP state
2QWP 1.75 Å, Crystal structure of disulfide-bond-crosslinked complex of bovine hsc70 (1-394aa)R171C…
7ODI 1.83 Å, Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with methanesulfonamide
2QW9 1.85 Å, Crystal structure of bovine hsc70 (1-394aa)in the apo state

Browse structure collections

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