1KC5: Antibody PC287

Crystal structure of antibody PC287 in complex with PS1 peptide. Determined by X-ray diffraction at 2.5 Å resolution. Released 24 Jul 2002.

Method: X-ray diffraction
Resolution: 2.5 Å
Organism: Mus musculus
Chains: 3
Atoms: 3,517
Mol. weight: 48.27 kDa
Released: 24 Jul 2002

Explore 1KC5 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1KC5 contains 8 α-helices and 44 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain H: 3 helices, 23 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	6
β-strand	11-12	2	7
β-strand	18-25	8	6
β-strand	34-40	7	8
β-strand	46-53	8	8
β-strand	58-60	3	8
β-strand	68-73	6	6
β-strand	78-83	6	6
α-helix	88-90	3
β-strand	92-100	9	8
β-strand	102-106	5	8
β-strand	110-112	3	8
β-strand	113-114	2	7
β-strand	120	1	9
β-strand	123-127	5	10
β-strand	138-148	11	10
β-strand	149	1	9
β-strand	154-157	4	11
α-helix	158-160	3
β-strand	162	1	11
β-strand	166-168	3	10
α-helix	169-171	3
β-strand	172-174	3	10
β-strand	177-187	11	10
β-strand	197-202	6	11
β-strand	207-212	6	11

Chain L: 5 helices, 21 β-strands

Element	Residues	Length	Sheet
β-strand	5-6	2	1
β-strand	10-13	4	2
β-strand	19-24	6	1
β-strand	33-38	6	2
β-strand	45-48	4	2
β-strand	54	1	2
β-strand	62-67	6	1
β-strand	70-75	6	1
α-helix	80-82	3
β-strand	85-90	6	2
β-strand	97-98	2	2
β-strand	102-106	5	2
β-strand	111	1	3
β-strand	114-118	5	4
α-helix	119-121	3
α-helix	122-125	4
β-strand	129-139	11	4
β-strand	140	1	3
β-strand	145-150	6	5
β-strand	153-154	2	5
β-strand	160-164	5	4
α-helix	165-167	3
β-strand	173-182	10	4
α-helix	183-186	4
β-strand	191-197	7	5
β-strand	205-210	6	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
PC287 Immunoglobulin	L	protein	214	Mus musculus	P01837 (AlphaFold model)
PC287 Immunoglobulin	H	protein	217	Mus musculus	P01869 (AlphaFold model)
PS1 peptide	P	protein	15		Q91C35

Sequence of entity 1 (L), FASTA

>1KC5_1 PC287 Immunoglobulin (chains L)
DIVLTQSPKSMSMSVGEKVTLSCKASENVDTYVSWYQQRPEQPPALLIYGASNRYTGVPD
RFTGSGSATDFTLTISSVQAEDLADYHCGQSYSYPLTFGGGTKLELKRADAAPTVSIFPP
SSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVANSWTAQDSKDSTYSMSSTLT
LTKDEYERHNSYTCEATHKTSTSPVVKSFNRNEC

Sequence of entity 2 (H), FASTA

>1KC5_2 PC287 Immunoglobulin (chains H)
QVKLQQSGPGLVKPSQSLSLTCTVTGYSITSDYAWNWIRQFPGNKLEWMAYISYSGSTTY
NPSLKSRISITRDTSKNQFFLQLNSVTTEDTAIYYCARGGTGFDYWGAGTTLTVSAAATT
PPSVYPLAPGSATAAASMVTLGCLVKGYFPEPVTVTWNSGALSSGVHTFPAVLQSDLYTL
SSSVTVPSSPWPSETVTCNVAHPASSTKVDKKIVPRD

Sequence of entity 3 (P), FASTA

>1KC5_3 PS1 peptide (chains P)
HQLDPAFGANSTNPD

Primary citation

Epitope recognition by diverse antibodies suggests conformational convergence in an antibody response. Nair, D.T., Singh, K., Siddiqui, Z. et al. J Immunol (2002) 168:2371-2382. PubMed

Other PDB entries of the same protein (UniProt P01837 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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3BKJ 1.59 Å, Crystal structure of Fab wo2 bound to the n terminal domain of amyloid beta peptide (1-16)
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2R1Y 1.6 Å, Crystal structure of S25-2 Fab in complex with Kdo analogues
2R2B 1.6 Å, Crystal structure of S25-2 Fab in complex with Kdo analogues
3BKM 1.6 Å, Structure of anti-amyloid-beta Fab WO2 (Form A, P212121)
3CFB 1.6 Å, High-resolution structure of blue fluorescent antibody EP2-19G2 in complex with stilbene…

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