1KSG: Complex of Arl2 and PDE delta, Crystal Form 1

Complex of Arl2 and PDE delta, Crystal Form 1. Determined by X-ray diffraction at 2.3 Å resolution. Released 8 May 2002.

Method: X-ray diffraction
Resolution: 2.3 Å
Organisms: Mus musculus, Homo sapiens
Chains: 2
Atoms: 2,597
Mol. weight: 39.17 kDa
Ligands: MG, GTP
Released: 8 May 2002

Explore 1KSG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1KSG contains 11 α-helices and 18 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	2-12	11
α-helix	14-15	2
β-strand	16-22	7	1
α-helix	29-35	7
β-strand	50-54	5	1
β-strand	57	1	2
β-strand	60	1	2
β-strand	61-67	7	1
α-helix	71-80	10
β-strand	86-92	7	1
α-helix	99-110	12
α-helix	113-115	3
β-strand	119-125	7	1
α-helix	135-141	7
α-helix	144-146	3
β-strand	152-156	5	1
β-strand	158	1	3
β-strand	163	1	3
α-helix	165-178	14

Chain B: 2 helices, 8 β-strands

Element	Residues	Length	Sheet
α-helix	6-14	9
β-strand	15-24	10	1
β-strand	29-34	6	1
α-helix	51-55	5
β-strand	59-67	9	1
β-strand	71-80	10	4
β-strand	88-97	10	4
β-strand	101-108	8	1
β-strand	130-135	6	4
β-strand	138-144	7	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
arf-like protein 2	A	protein	186	Mus musculus	Q9D0J4 (AlphaFold model)
Retinal rod rhodopsin-sensitive cgmp 3',5'-cyclic phosphodiesterase delta-subunit	B	protein	152	Homo sapiens	O43924 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1KSG_1 arf-like protein 2 (chains A)
GSMGLLTILKKMKQKERELRLLMLGLDNAGKTTILKKFNGEDVDTISPTLGFNIKTLEHR
GFKLNIWDVGGQKSLRSYWRNYFESTDGLIWVVDSADRQRMQDCQRELQSLLVEERLAGA
TLLIFANKQDLPGALSCNAIQEALELDSIRSHHWRIQGCSAVTGEDLLPGIDWLLDDISS
RVFTAD

Sequence of entity 2 (B), FASTA

>1KSG_2 RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE DELTA-SUBUNIT (chains B)
GSMSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKA
VSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMM
PASVLTGNVIIETKFFDDDLLVSTSRVRLFYV

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	1
GTP	Guanosine-5'-triphosphate	C10 H16 N5 O14 P3	1

Primary citation

The complex of Arl2-GTP and PDE delta: from structure to function. Hanzal-Bayer, M., Renault, L., Roversi, P. et al. EMBO J (2002) 21:2095-2106. DOI 10.1093/emboj/21.9.2095 · PubMed

Other PDB entries of the same protein (UniProt Q9D0J4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1KSH 1.8 Å, Complex of Arl2 and PDE delta, Crystal Form 2 (native)
1KSJ 2.6 Å, Complex of Arl2 and PDE delta, Crystal Form 2 (SeMet)
4GOK 2.6 Å, The Crystal structure of Arl2GppNHp in complex with UNC119a

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