1KXG: B lymphocyte stimulator

The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator. Determined by X-ray diffraction at 2.0 Å resolution. Released 20 Mar 2002.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: Homo sapiens
Chains: 6
Atoms: 7,473
Mol. weight: 104.66 kDa
Ligands: MG, CIT, DIO
Released: 20 Mar 2002

Explore 1KXG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1KXG contains 12 α-helices and 78 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	146-151	6	1
α-helix	156-157	2
β-strand	158-160	3	2
β-strand	163-165	3	2
α-helix	166-167	2
β-strand	168-174	7	1
β-strand	178-181	4	2
β-strand	184-187	4	2
β-strand	191-201	11	1
β-strand	207-215	9	2
β-strand	226-235	10	2
β-strand	243-253	11	1
β-strand	258-263	6	2
β-strand	270-271	2	1
β-strand	278-283	6	1

Chains B, D and E: 2 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	146-151	6	3
α-helix	156-157	2
β-strand	158-160	3	4
β-strand	163-165	3	4
α-helix	166-167	2
β-strand	168-174	7	3
β-strand	178-181	4	4
β-strand	184-187	4	4
β-strand	191-201	11	3
β-strand	208-215	8	4
β-strand	226-234	9	4
β-strand	243-253	11	3
β-strand	258-263	6	4
β-strand	270	1	3
β-strand	278-283	6	3

Chain C: 2 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	146-151	6	5
α-helix	156-157	2
β-strand	158-160	3	6
β-strand	163-165	3	6
α-helix	166-167	2
β-strand	168-174	7	5
β-strand	178-181	4	6
β-strand	184-187	4	6
β-strand	191-201	11	5
β-strand	207-215	9	6
β-strand	226-235	10	6
β-strand	243-253	11	5
β-strand	258-263	6	6
β-strand	270	1	5
β-strand	278-283	6	5

Chain F: 2 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	146-151	6	11
α-helix	156-157	2
β-strand	158-160	3	12
β-strand	163-165	3	12
α-helix	166-167	2
β-strand	168-174	7	11
β-strand	178-181	4	12
β-strand	184-187	4	12
β-strand	191-201	11	11
β-strand	208-215	8	12
β-strand	226-234	9	12
β-strand	243-253	11	11
β-strand	258-263	6	12
β-strand	270-271	2	11
β-strand	278-283	6	11

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
B lymphocyte stimulator	A, B, C, D, E, F	protein	152	Homo sapiens	Q9Y275 (AlphaFold model)

Sequence of entity 1 (A, B, C, D, E, F), FASTA

>1KXG_1 B lymphocyte stimulator (chains A, B, C, D, E, F)
AVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYF
FIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKL
EEGDELQLAIPRENAQISLDGDVTFFGALKLL

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	7
CIT	Citric acid	C6 H8 O7	2
DIO	1,4-diethylene dioxide	C4 H8 O2	20

Primary citation

Structural basis of BLyS receptor recognition. Oren, D.A., Li, Y., Volovik, Y. et al. Nat Struct Biol (2002) 9:288-292. DOI 10.1038/nsb769 · PubMed

Other PDB entries of the same protein (UniProt Q9Y275 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5Y9J 2.05 Å, BAFF in complex with belimumab
4ZCH 2.43 Å, Single-chain human APRIL-BAFF-BAFF Heterotrimer
1OQE 2.5 Å, Crystal structure of sTALL-1 with BAFF-R
8ZUJ 2.58 Å, Pentagonal cluster of BAFF-BAFFR ectodomain complex
1OQD 2.6 Å, Crystal structure of sTALL-1 and BCMA
1KD7 2.8 Å, Crystal structure of an extracellular domain fragment of human BAFF
6FXN 2.9 Å, Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody…
1JH5 3.0 Å, Crystal Structure of sTALL-1 of TNF family ligand
1OSG 3.0 Å, Complex between BAFF and a BR3 derived peptide presented in a beta-hairpin scaffold
3V56 3.0 Å, Re-refinement of PDB entry 1OSG - Complex between BAFF and a BR3 derived peptide…
4V46 3.3 Å, Crystal structure of the BAFF-BAFF-R complex

Browse structure collections

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