1OSG: PDB entry 1OSG

Complex between BAFF and a BR3 derived peptide presented in a beta-hairpin scaffold. Determined by X-ray diffraction at 3.0 Å resolution. Released 27 May 2003.

Method: X-ray diffraction
Resolution: 3.0 Å
Organism: Homo sapiens
Chains: 12
Atoms: 7,531
Mol. weight: 146 kDa
Ligands: MG
Released: 27 May 2003

Explore 1OSG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1OSG contains 6 α-helices and 101 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 14 β-strands

Element	Residues	Length	Sheet
β-strand	146-151	6	1
α-helix	156-157	2
β-strand	158-160	3	2
β-strand	163-165	3	2
β-strand	168-174	7	1
β-strand	178-181	4	3
β-strand	184-187	4	3
β-strand	191-201	11	1
β-strand	207-215	9	3
β-strand	226-235	10	3
β-strand	243-253	11	1
β-strand	258-262	5	3
β-strand	263	1	2
β-strand	270	1	1
β-strand	278-283	6	1

Chain B: 1 helix, 16 β-strands

Element	Residues	Length	Sheet
β-strand	146-151	6	4
α-helix	156-157	2
β-strand	158-160	3	5
β-strand	163-165	3	5
β-strand	168-174	7	4
β-strand	178-181	4	6
β-strand	184-187	4	6
β-strand	191-201	11	4
β-strand	207-208	2	7
β-strand	211-215	5	6
β-strand	226-231	6	6
β-strand	234-235	2	7
β-strand	243-253	11	4
β-strand	258-262	5	6
β-strand	263	1	5
β-strand	270-271	2	4
β-strand	278-283	6	4

Chain C: 1 helix, 13 β-strands

Element	Residues	Length	Sheet
β-strand	146-151	6	8
α-helix	156-157	2
β-strand	158-160	3	9
β-strand	163-165	3	9
β-strand	168-174	7	8
β-strand	178-181	4	9
β-strand	184-187	4	9
β-strand	191-201	11	8
β-strand	207-215	9	9
β-strand	226-235	10	9
β-strand	243-253	11	8
β-strand	258-263	6	9
β-strand	270	1	8
β-strand	278-283	6	8

Chain D: 1 helix, 17 β-strands

Element	Residues	Length	Sheet
β-strand	146-151	6	10
α-helix	156-157	2
β-strand	158	1	11
β-strand	164	1	12
β-strand	165	1	11
β-strand	168-174	7	10
β-strand	178-180	3	13
β-strand	185-187	3	13
β-strand	191-201	11	10
β-strand	207-208	2	14
β-strand	211-215	5	13
β-strand	226-231	6	13
β-strand	234-235	2	14
β-strand	243-253	11	10
β-strand	258-262	5	13
β-strand	263	1	12
β-strand	270-271	2	10
β-strand	278-283	6	10

Chain E: 0 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	146-151	6	15
β-strand	158-159	2	16
β-strand	164-165	2	16
β-strand	168-174	7	15
β-strand	178-180	3	17
β-strand	185-187	3	17
β-strand	191-201	11	15
β-strand	207-215	9	17
β-strand	226-235	10	17
β-strand	243-253	11	15
β-strand	258-262	5	17
β-strand	263	1	16
β-strand	270	1	15
β-strand	278-283	6	15

Chain F: 2 helices, 15 β-strands

Element	Residues	Length	Sheet
β-strand	146-151	6	18
α-helix	156-157	2
β-strand	158-160	3	19
β-strand	163-165	3	19
α-helix	166-167	2
β-strand	168-174	7	18
β-strand	178-181	4	19
β-strand	184-187	4	19
β-strand	191-201	11	18
β-strand	207-208	2	20
β-strand	211-215	5	19
β-strand	226-231	6	19
β-strand	234-235	2	20
β-strand	243-253	11	18
β-strand	258-263	6	19
β-strand	270	1	18
β-strand	278-283	6	18

Chains G, H, I, K and L: 0 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	24-26	3	21
β-strand	31-33	3	21

Chain J: 0 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	24	1	22
β-strand	33	1	22

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Tumor necrosis factor ligand superfamily member 13B	A, B, C, D, E, F	protein	208	Homo sapiens	Q9Y275 (AlphaFold model)
BR3 derived PEPTIDE	G, H, I, J, K, L	protein	12

Sequence of entity 1 (A, B, C, D, E, F), FASTA

>1OSG_1 Tumor necrosis factor ligand superfamily member 13B (chains A, B, C, D, E, F)
GSHMELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQG
PEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYG
QVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGD
ELQLAIPRENAQISLDGDVTFFGALKLL

Sequence of entity 2 (G, H, I, J, K, L), FASTA

>1OSG_2 BR3 derived PEPTIDE (chains G, H, I, J, K, L)
CHWDLLVRHWVC

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	4

Primary citation

BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site. Gordon, N.C., Pan, B., Hymowitz, S.G. et al. Biochemistry (2003) 42:5977-5983. DOI 10.1021/bi034017g · PubMed

Other PDB entries of the same protein (UniProt Q9Y275 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1KXG 2.0 Å, The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator.
5Y9J 2.05 Å, BAFF in complex with belimumab
4ZCH 2.43 Å, Single-chain human APRIL-BAFF-BAFF Heterotrimer
1OQE 2.5 Å, Crystal structure of sTALL-1 with BAFF-R
8ZUJ 2.58 Å, Pentagonal cluster of BAFF-BAFFR ectodomain complex
1OQD 2.6 Å, Crystal structure of sTALL-1 and BCMA
1KD7 2.8 Å, Crystal structure of an extracellular domain fragment of human BAFF
6FXN 2.9 Å, Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody…
1JH5 3.0 Å, Crystal Structure of sTALL-1 of TNF family ligand
3V56 3.0 Å, Re-refinement of PDB entry 1OSG - Complex between BAFF and a BR3 derived peptide…
4V46 3.3 Å, Crystal structure of the BAFF-BAFF-R complex

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