1OED: Acetylcholine receptor pore from electron images

Structure of acetylcholine receptor pore from electron images. Determined by electron microscopy at 4.0 Å resolution. Released 26 Jun 2003.

Method
Electron microscopy
Resolution
4.0 Å
Organism
Torpedo marmorata
Chains
5
Atoms
4,926
Mol. weight
137.86 kDa
Released
26 Jun 2003

Explore 1OED in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1OED contains 24 α-helices and 0 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and D: 5 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix213-23826
α-helix240-2423
α-helix243-27028
α-helix276-30126
α-helix405-43632
Chain B: 5 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix219-24426
α-helix246-2483
α-helix249-27628
α-helix284-30623
α-helix433-46129
Chain C: 4 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix227-25226
α-helix257-28428
α-helix290-31526
α-helix453-48331
Chain E: 5 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix222-2276
α-helix229-24517
α-helix251-27929
α-helix286-31025
α-helix446-47732

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Acetylcholine receptor subunit alphaA, Dprotein227Torpedo marmorataP02711 (AlphaFold model)
Acetylcholine receptor beta subunitBprotein250Torpedo marmorataP02712 (AlphaFold model)
Acetylcholine receptor delta subunitCprotein260Torpedo marmorataP02718 (AlphaFold model)
Acetylcholine receptor gamma subunitEprotein260Torpedo marmorataP02714 (AlphaFold model)
Sequence of entity 1 (A, D), FASTA
>1OED_1 Acetylcholine receptor subunit alpha (chains A, D)
PLYFVVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSA
VPLIGKYMLFTMIFVISSIIITVVVINTHHRSPSTHTMPQWVRKIFIDTIPNVMFFSTMK
RASKEKQENKIFADDIDISDISGKQVTGEVIFQTPLIKNPDVKSAIEGVKYIAEHMKSDE
ESSNAAEEWKYVAMVIDHILLCVFMLICIIGTVSVFAGRLIELSQEG
Sequence of entity 2 (B), FASTA
>1OED_2 Acetylcholine receptor beta subunit (chains B)
PLFYIVYTIIPCILISILAILVFYLPPDAGEKMSLSISALLAVTVFLLLLADKVPETSLS
VPIIIRYLMFIMILVAFSVILSVVVLNLHHRSPNTHTMPNWIRQIFIETLPPFLWIQRPV
TTPSPDSKPTIISRANDEYFIRKPAGDFVCPVDNARVAVQPERLFSEMKWHLNGLTQPVT
LPQDLKEAVEAIKYIAEQLESASEFDDLKKDWQYVAMVADRLFLYVFFVICSIGTFSIFL
DASHNVPPDN
Sequence of entity 3 (C), FASTA
>1OED_3 Acetylcholine receptor delta subunit (chains C)
PLFYVINFITPCVLISFLASLAFYLPAESGEKMSTAISVLLAQAVFLLLTSQRLPETALA
VPLIGKYLMFIMSLVTGVIVNCGIVLNFHFRTPSTHVLSTRVKQIFLEKLPRILHMSRAD
ESEQPDWQNDLKLRRSSSVGYISKAQEYFNIKSRSELMFEKQSERHGLVPRVTPRIGFGN
NNENIAASDQLHDEIKSGIDSTNYIVKQIKEKNAYDEEVGNWNLVGQTIDRLSMFIITPV
MVLGTIFIFVMGNFNHPPAK
Sequence of entity 4 (E), FASTA
>1OED_4 Acetylcholine receptor gamma subunit (chains E)
PLFYIINIIAPCVLISSLVVLVYFLPAQAGGQKCTLSISVLLAQTIFLFLIAQKVPETSL
NVPLIGKYLIFVMFVSMLIVMNCVIVLNVSLRTPNTHSLSEKIKHLFLGFLPKYLGMQLE
PSEETPEKPQPRRRSSFGIMIKAEEYILKKPRSELMFEEQKDRHGLKRVNKMTSDIDIGT
TVDLYKDLANFAPEIKSCVEACNFIAKSTKEQNDSGSENENWVLIGKVIDKACFWIALLL
FSIGTLAIFLTGHFNQVPEF

Primary citation

Structure and Gating Mechanism of the Acetylcholine Receptor Pore. Miyazawa, A., Fujiyoshi, Y., Unwin, N. Nature (2003) 423:949. DOI 10.1038/NATURE01748 · PubMed

Other PDB entries of the same protein (UniProt P02711 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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