1P4U: GGA3 gae domain

Crystal structure of GGA3 gae domain in complex with rabaptin-5 peptide. Determined by X-ray diffraction at 2.2 Å resolution. Released 29 Jul 2003.

Method: X-ray diffraction
Resolution: 2.2 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,373
Mol. weight: 17.84 kDa
Released: 29 Jul 2003

Explore 1P4U in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1P4U contains 6 α-helices and 17 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 6 helices, 15 β-strands

Element	Residues	Length	Sheet
α-helix	588-590	3
α-helix	591-592	2
β-strand	593	1	1
α-helix	597-598	2
β-strand	599-604	6	2
β-strand	607-613	7	2
β-strand	614	1	1
β-strand	624-633	10	2
β-strand	639	1	3
β-strand	640-647	8	4
β-strand	649	1	5
β-strand	653-656	4	2
α-helix	657-659	3
β-strand	664	1	3
α-helix	665-667	3
β-strand	668	1	6
β-strand	671	1	6
β-strand	675-683	9	2
β-strand	692-700	9	4
β-strand	703-711	9	4
α-helix	717-719	3

Chain B: 0 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	0	1	5
β-strand	4	1	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
ADP-ribosylation factor binding protein GGA3	A	protein	153	Homo sapiens	Q9NZ52 (AlphaFold model)
Rabaptin-5	B	protein	13		Q15276 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1P4U_1 ADP-ribosylation factor binding protein GGA3 (chains A)
GSPPKGPELSLASIHVPLESIKPSSALPVTAYDKNGFRILFHFAKECPPGRPDVLVVVVS
MLNMAPLPVKSIVLQAAAPKSMKVKLQPPSGTELSPFSPIQPPAAITQVMLLANPLKEKV
RLRYKLTFALGEQLSTEVGEVDQFPPVEQWGNL

Sequence of entity 2 (B), FASTA

>1P4U_2 Rabaptin-5 (chains B)
DESDFGPLVGADS

Primary citation

RECOGNITION OF ACCESSORY PROTEIN MOTIFS BY THE GAMMA-ADAPTIN EAR DOMAIN OF GGA3. MILLER, G.J., MATTERA, R., BONIFACINO, J.S. et al. Nat Struct Biol (2003) 10:599-606. DOI 10.1038/nsb953 · PubMed

Other PDB entries of the same protein (UniProt Q9NZ52 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1JUQ 2.2 Å, GGA3 VHS domain complexed with C-terminal peptide from cation-dependent Mannose…
1LF8 2.3 Å, Complex of GGA3-VHS Domain and CI-MPR C-terminal Phosphopeptide
1JPL 2.4 Å, GGA3 VHS domain complexed with C-terminal peptide from cation-independent mannose…
1WR6 2.6 Å, Crystal structure of GGA3 GAT domain in complex with ubiquitin
1YD8 2.8 Å, Complex of human GGA3 gat domain and ubiquitin

Browse structure collections

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