1P7Q: HLA-A2

Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor. Determined by X-ray diffraction at 3.4 Å resolution. Released 14 Oct 2003.

Method: X-ray diffraction
Resolution: 3.4 Å
Organism: Homo sapiens
Chains: 4
Atoms: 4,498
Mol. weight: 66.69 kDa
Released: 14 Oct 2003

Explore 1P7Q in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1P7Q contains 18 α-helices and 59 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 13 helices, 24 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	1
α-helix	20	1
β-strand	21-28	8	1
β-strand	31-37	7	1
β-strand	46-47	2	1
α-helix	50-53	4
α-helix	57-84	28
β-strand	94-103	10	1
β-strand	109-118	10	1
β-strand	122-126	5	1
β-strand	133-134	2	1
α-helix	138-140	3
α-helix	141-150	10
α-helix	152-155	4
α-helix	157-159	3
α-helix	160-164	5
α-helix	165-174	10
α-helix	176-179	4
β-strand	183	1	2
α-helix	184-185	2
β-strand	186	1	3
β-strand	189-193	5	4
β-strand	198-203	6	4
β-strand	206	1	3
β-strand	208	1	5
β-strand	209	1	2
β-strand	214-217	4	6
β-strand	218	1	7
β-strand	223	1	7
β-strand	229-230	2	4
β-strand	234-235	2	5
β-strand	241-242	2	5
β-strand	245-250	6	4
α-helix	254-256	3
β-strand	258-262	5	6
α-helix	269	1
β-strand	270-273	4	6

Chain B: 0 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	2	1	8
β-strand	3	1	9
β-strand	6-11	6	10
β-strand	22-30	9	10
β-strand	31	1	9
β-strand	36-41	6	11
β-strand	44-45	2	11
β-strand	50-51	2	10
β-strand	55-56	2	10
β-strand	62-69	8	10
β-strand	78-83	6	11
β-strand	87	1	12
β-strand	91-94	4	11

Chain D: 5 helices, 22 β-strands

Element	Residues	Length	Sheet
β-strand	9-11	3	13
β-strand	16-17	2	12
β-strand	22-25	4	13
β-strand	36-39	4	14
α-helix	45-48	4
α-helix	52-55	4
β-strand	59-62	4	13
β-strand	71-76	6	14
α-helix	87-90	4
β-strand	91-93	3	14
β-strand	95-99	5	12
α-helix	100-102	3
β-strand	103-107	5	15
β-strand	111-113	3	16
β-strand	118-123	6	15
β-strand	126	1	8
β-strand	130-135	6	17
β-strand	143	1	17
β-strand	146-147	2	17
β-strand	149	1	15
β-strand	156-161	6	15
β-strand	171-178	8	17
β-strand	181-185	5	17
β-strand	186	1	12
α-helix	187-191	5
β-strand	192-193	2	17
β-strand	195-197	3	16

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
HLA class I histocompatibility antigen, A-2 alpha chain	A	protein	276	Homo sapiens	P04439 (AlphaFold model)
Beta-2-microglobulin	B	protein	99	Homo sapiens	P61769 (AlphaFold model)
POL polyprotein	C	protein	9		P12499
leukocyte immunoglobulin-like receptor 1	D	protein	197	Homo sapiens	Q8NHL6 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1P7Q_1 HLA class I histocompatibility antigen, A-2 alpha chain (chains A)
GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYW
DGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDG
KDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQ
RTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEP

Sequence of entity 2 (B), FASTA

>1P7Q_2 Beta-2-microglobulin (chains B)
IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDW
SFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Sequence of entity 3 (C), FASTA

>1P7Q_3 POL polyprotein (chains C)
ILKEPVHGV

Sequence of entity 4 (D), FASTA

>1P7Q_4 leukocyte immunoglobulin-like receptor 1 (chains D)
HLPKPTLWAEPGSVITQGSPVTLRCQGGQETQEYRLYREKKTAPWITRIPQELVKKGQFP
IPSITWEHAGRYRCYYGSDTAGRSESSDPLELVVTGAYIKPTLSAQPSPVVNSGGNVTLQ
CDSQVAFDGFILCKEGEDEHPQCLNSQPHARGSSRAIFSVGPVSPSRRWWYRCYAYDSNS
PYEWSLPSDLLELLVLG

Primary citation

Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor. Willcox, B.E., Thomas, L.M., Bjorkman, P.J. Nat Immunol (2003) 4:913-919. DOI 10.1038/ni961 · PubMed

Other PDB entries of the same protein (UniProt P04439 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3MRE 1.1 Å, Crystal Structure of MHC class I HLA-A2 molecule complexed with EBV bmlf1-280-288…
3D25 1.3 Å, Crystal structure of HA-1 minor histocompatibility antigen bound to human class I MHC…
3MRG 1.3 Å, Crystal Structure of MHC class I HLA-A2 molecule complexed with HCV NS3-1073-1081…
6JOZ 1.35 Å, Crystal structure of BRLF peptide from EBV in complex with HLA-A1101.
5C0G 1.37 Å, HLA-A02 carrying YLGGPDFPTI
5N1Y 1.39 Å, HLA-A02 carrying MVWGPDPLYV
1I4F 1.4 Å, Crystal structure of HLA-A*0201/MAGE-A4-peptide complex
1OGA 1.4 Å, A structural basis for immunodominant human T-cell receptor recognition.
3MRB 1.4 Å, Crystal Structure of MHC class I HLA-A2 molecule complexed with HCMV pp65-495-503…
3MRK 1.4 Å, Crystal Structure of MHC class I HLA-A2 molecule complexed with AFP137 nonapeptide
6J2A 1.4 Å, The structure of HLA-A*3003/NP44
1X7Q 1.45 Å, Crystal structure of HLA-A*1101 with sars nucleocapsid peptide

Browse structure collections

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