1Q4G: Prostaglandin G/H synthase 1

2.0 Angstrom Crystal Structure of Ovine Prostaglandin H2 Synthase-1, in complex with alpha-methyl-4-biphenylacetic acid. Determined by X-ray diffraction at 2.0 Å resolution. Released 6 Jan 2004.

Method

X-ray diffraction

Resolution

2.0 Å

Organism

Ovis aries

Chains

2

Atoms

10,336

Mol. weight

136.1 kDa

Ligands

HEM, BFL, BOG

Released

6 Jan 2004

Explore 1Q4G in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1Q4G contains 94 α-helices and 62 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 46 helices, 31 β-strands

Molecules and chains

>1Q4G_1 Prostaglandin G/H synthase 1 (chains A, B)
PVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPEIWTWLRTTLRPSPSFIHF
LLTHGRWLWDFVNATFIRDTLMRLVLTVRSNLIPSPPTYNIAHDYISWESFSNVSYYTRI
LPSVPRDCPTPMGTKGKKQLPDAEFLSRRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFK
TSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQMLNGEVYPPSVEEAPV
LMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATIWLREHNRVCDLLKAEHPTWGDEQLFQT
ARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGAQFQYRNRIAMEFNQLYHWHPLM
PDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQPAGRIGGGRNIDHHILHVAVDV
IKESRVLRLQPFNEYRKRFGMKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEK
CHPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKASTFGGEVGFNLVKTATLKKLVCLN
TKTCPYVSFHVPD

Ligands and cofactors

Water and common crystallization additives (GOL) are not listed.

Primary citation

The 2.0A Resolution Crystal Structure of Prostaglandin H(2) Synthase-1: Structural Insights into an Unusual Peroxidase. Gupta, K., Selinsky, B.S., Kaub, C.J. et al. J Mol Biol (2004) 335:503-518. DOI 10.1016/j.jmb.2003.10.073 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P05979 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 2AYL 2.0 Å, 2.0 Angstrom Crystal Structure of Manganese Protoporphyrin IX-reconstituted Ovine…
• 4O1Z 2.4 Å, Crystal Structure of Ovine Cyclooxygenase-1 Complex with Meloxicam
• 3N8Y 2.6 Å, Structure of Aspirin Acetylated Cyclooxygenase-1 in Complex with Diclofenac
• 1EQG 2.61 Å, The 2.6 Å model of ovine cox-1 complexed with ibuprofen
• 1HT8 2.69 Å, The 2.7 Å resolution model of ovine cox-1 complexed with alclofenac
• 1EQH 2.7 Å, The 2.7 Å model of ovine cox-1 complexed with flurbiprofen
• 2OYU 2.7 Å, Indomethacin-(S)-alpha-ethyl-ethanolamide bound to Cyclooxygenase-1
• 1HT5 2.75 Å, The 2.75 Å resolution model of ovine cox-1 complexed with methyl ester flurbiprofen
• 3KK6 2.75 Å, Crystal Structure of Cyclooxygenase-1 in complex with celecoxib
• 3N8W 2.75 Å, Crystal Structure of R120Q/Native Cyclooxygenase-1 Heterodimer mutant in complex with…
• 3N8X 2.75 Å, Crystal Structure of Cyclooxygenase-1 in Complex with Nimesulide
• 5WBE 2.75 Å, Cox-1:MOFEZOLAC complex structure

Browse structure collections

About this viewer

MolViewer shows 1Q4G directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.