1QU3: Isoleucyl-tRNA synthetase

Insights into editing from an ile-tRNA synthetase structure with trna(ile) and mupirocin. Determined by X-ray diffraction at 2.9 Å resolution. Released 31 Aug 1999.

Method
X-ray diffraction
Resolution
2.9 Å
Organism
Staphylococcus aureus
Chains
2
Atoms
8,870
Mol. weight
129.86 kDa
Ligands
ZN, MRC
Released
31 Aug 1999

Explore 1QU3 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1QU3 contains 46 α-helices and 45 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 46 helices, 45 β-strands

ElementResiduesLengthSheet
α-helix20-3415
α-helix36-449
β-strand4911
α-helix53-553
β-strand5812
α-helix65-8319
β-strand8711
β-strand93-9423
β-strand9512
α-helix100-1067
α-helix118-1214
α-helix122-1243
α-helix126-14116
β-strand152-15323
α-helix157-17115
β-strand178-18584
β-strand19214
α-helix195-1973
β-strand198-20035
β-strand208-20926
β-strand21217
β-strand213-21428
α-helix218-2203
β-strand22717
β-strand230-23126
α-helix237-2393
β-strand242-24549
β-strand26217
α-helix268-2747
α-helix290-2934
β-strand298-29928
α-helix301-3033
β-strand307-30828
β-strand309-31249
β-strand32619
α-helix332-3398
β-strand356110
β-strand358110
α-helix361-3644
α-helix369-37810
α-helix380-3834
β-strand38716
β-strand395-39735
β-strand402-40325
β-strand405-41284
β-strand413-414211
α-helix416-4194
α-helix422-4287
β-strand431-432212
α-helix436-44813
β-strand451-452211
β-strand455113
β-strand462113
β-strand466-467214
β-strand474114
α-helix479-49012
α-helix494-4974
α-helix501-5033
β-strand519-520214
β-strand524113
α-helix528-5325
α-helix5341
α-helix535-5395
β-strand549-555712
α-helix556-5583
α-helix564-57411
β-strand579-585712
β-strand588-589215
α-helix607-6137
α-helix615-6228
β-strand631-632215
α-helix635-65723
α-helix671-6733
α-helix676-69722
α-helix702-7109
α-helix711-72111
α-helix722-7287
α-helix736-74813
α-helix750-7567
α-helix761-7699
α-helix779-7813
α-helix783-7864
α-helix792-81726
β-strand827-832616
β-strand834117
β-strand837117
α-helix839-8424
α-helix849-8524
β-strand857-860416
β-strand870-871216
β-strand874-880716

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Isoleucyl-tRNATRNA75Staphylococcus aureus
Isoleucyl-tRNA synthetaseAprotein917Staphylococcus aureusP41972 (AlphaFold model)
Sequence of entity 1 (T), FASTA
>1QU3_1 ISOLEUCYL-TRNA (chains T)
GGGCUUGUAGCUCAGGUGGUUAGAGCGCACCCCUGAUAAGGGUGAGGUCGGUGGUUCAAG
UCCACUCAGGCCCAC
Sequence of entity 2 (A), FASTA
>1QU3_2 ISOLEUCYL-TRNA SYNTHETASE (chains A)
MDYEKTLLMPKTDFPMRGGLPNKEPQIQEKWDAEDQYHKALEKNKGNETFILHDGPPYAN
GNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPIEQALTKKGVDRKKMSTAEF
REKCKEFALEQIELQKKDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMADKGLIYKGK
KPVYWSPSSESSLAEAEIEYHDKRSASIYVAFNVKDDKGVVDADAKFIIWTTTPWTIPSN
VAITVHPELKYGQYNVNGEKYIIAEALSDAVAEALDWDKASIKLEKEYTGKELEWVVAQH
PFLDRESLVINGDHVTTDAGTGCVHTAPGHGEDDYIVGQQYELPVISPIDDKGVFTEEGG
QFEGMFYDKANKAVTDLLTEKGALLKLDFITHSYPHDWRTKKPVIFRATPQWFASISKVR
QDILDAIENTNFKVNWGKTRIYNMVRDRGEWVISRQRVWGVPLPVFYAENGEIIMTKETV
NHVADLFAEHGSNIWFEREAKDLLPEGFTHPGSPNGTFTKETDIMDVWFDSGSSHRGVLE
TRPELSFPADMYLEGSDQYRGWFNSSITTSVATRGVSPYKFLLSHGFVMDGEGKKMSKSL
GNVIVPDQVVKQKGADIARLWVSSTDYLADVRISDEILKQTSDDYRKIRNTLRFMLGNIN
DFNPDTDSIPESELLEVDRYLLNRLREFTASTINNYENFDYLNIYQEVQNFINVELSNFY
LDYGKDILYIEQRDSHIRRSMQTVLYQILVDMTKLLAPILVHTAEEVWSHTPHVKEESVH
LADMPKVVEVDQALLDKWRTFMNLRDDVNRALETARNEKVIGKSLEAKVTIASNDKFNAS
EFLTSFDALHQLFIVSQVKVVDKLDDQATAYEHGDIVIEHADGEKCERCWNYSEDLGAVD
ELTHLCPRCQQVVKSLV

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn1
MRCMupirocinC26 H44 O91

Primary citation

Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin. Silvian, L.F., Wang, J., Steitz, T.A. Science (1999) 285:1074-1077. DOI 10.1126/science.285.5430.1074 · PubMed

Other PDB entries of the same protein (UniProt P41972 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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