1S7P: Thermolysin digested microcin J25

Solution structure of thermolysin digested microcin J25. Determined by solution NMR. Released 15 Jun 2004.

Method: Solution NMR
Organism: Escherichia coli
Chains: 2
Atoms: 152
Mol. weight: 2.14 kDa
Released: 15 Jun 2004

Explore 1S7P in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1S7P contains 0 α-helices and 3 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 0 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	2	1	1
β-strand	6-7	2	1

Chain B: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	19-20	2	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
microcin J25	B	protein	11	Escherichia coli	Q9X2V7 (AlphaFold model)
microcin J25	A	protein	10	Escherichia coli	Q9X2V7 (AlphaFold model)

Sequence of entity 1 (B), FASTA

>1S7P_1 microcin J25 (chains B)
VGIGTPISFYG

Sequence of entity 2 (A), FASTA

>1S7P_2 microcin J25 (chains A)
GGAGHVPEYF

Primary citation

Structure of thermolysin cleaved microcin J25: extreme stability of a two-chain antimicrobial peptide devoid of covalent links. Rosengren, K.J., Blond, A., Afonso, C. et al. Biochemistry (2004) 43:4696-4702. DOI 10.1021/bi0361261 · PubMed

Other PDB entries of the same protein (UniProt Q9X2V7 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4CU4 2.3 Å, FhuA from E. coli in complex with the lasso peptide microcin J25 (MccJ25)
6N60 3.68 Å, Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA…
1PP5 Structure of Antibacterial Peptide Microcin J25: a 21-Residue Lariat Protoknot
1Q71 The structure of microcin J25 is a threaded sidechain-to-backbone ring structure and not…
23FQ Dipeptide removal from MccJ25 yields a new lasso peptide delta-VG
2MMT Lasso peptide-based integrin inhibitor: Microcin J25 variant with RGDF substitution of…
2MMW Lasso peptide based integrin inhibitor: microcin J25 variant with rgd substitution of…
5T56 [3]catenane from MccJ25 G12R/I13C/G21C lasso peptide

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