1T38: Human O6-alkylguanine-DNA alkyltransferase

Human O6-alkylguanine-DNA alkyltransferase bound to DNA containing O6-methylguanine. Determined by X-ray diffraction at 3.2 Å resolution. Released 13 Jul 2004.

Method: X-ray diffraction
Resolution: 3.2 Å
Organism: Homo sapiens
Chains: 3
Atoms: 1,697
Mol. weight: 28.3 kDa
Released: 13 Jul 2004

Explore 1T38 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1T38 contains 7 α-helices and 8 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	8-12	5	1
β-strand	19-24	6	1
β-strand	27-33	7	1
α-helix	57-71	15
α-helix	73-75	3
α-helix	80-83	4
β-strand	84	1	1
α-helix	94-105	12
β-strand	112-113	2	2
α-helix	114-121	8
α-helix	127-136	10
β-strand	140	1	3
β-strand	143	1	3
β-strand	148-149	2	2
α-helix	163-171	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
5'-D(GPCPCPAPTPGP(6OG)PCPTPAPGPTP*A)-3'	B	DNA	13
5'-d(tpapcptpapgpcpcpaptpgpgp*c)-3'	C	DNA	13
Methylated-DNA--protein-cysteine methyltransferase	A	protein	188	Homo sapiens	P16455 (AlphaFold model)

Sequence of entity 1 (B), FASTA

>1T38_1 5'-D(*GP*CP*CP*AP*TP*GP*(6OG)P*CP*TP*AP*GP*TP*A)-3' (chains B)
GCCATGGCTAGTA

Sequence of entity 2 (C), FASTA

>1T38_2 5'-D(*TP*AP*CP*TP*AP*GP*CP*CP*AP*TP*GP*GP*C)-3' (chains C)
TACTAGCCATGGC

Sequence of entity 3 (A), FASTA

>1T38_3 Methylated-DNA--protein-cysteine methyltransferase (chains A)
MRGSHHHHHHGSMDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAVEVPA
PAAVLGGPEPLMQCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKF
GEVISYQQLAALAGNPKAARAVGGAMRGNPVPILIPSHRVVCSSGAVGNYSGGLAVKEWL
LAHEGHRL

Primary citation

DNA binding and nucleotide flipping by the human DNA repair protein AGT. Daniels, D.S., Woo, T.T., Luu, K.X. et al. Nat Struct Mol Biol (2004) 11:714-720. DOI 10.1038/nsmb791 · PubMed

Other PDB entries of the same protein (UniProt P16455 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1QNT 1.9 Å, X-ray structure of human O6alkylguanine-DNA alkyltransferase
1EH6 2.0 Å, Human O6-alkylguanine-DNA alkyltransferase
1EH7 2.0 Å, Methylated human O6-alkylguanine-DNA alkyltransferase
9QF2 2.42 Å, Cryo-EM structure of the fully Coronin-1B-decorated actin filament in the ADP state.
1EH8 2.5 Å, Benzylated human O6-alkylguanine-DNA alkyltransferase
28OP 2.7 Å, Structure of the human inner kinetochore CCAN and CENP-C bound to DNA
9QEY 2.74 Å, Cryo-EM structure of the actin filament bound by a single Coronin-1B molecule.
9QFB 2.74 Å, Cryo-EM structure of the fully Coronin-1B-decorated actin filament in the ADP state.
9QFQ 2.76 Å, Cryo-EM structure of the cofilactin barbed end bound by AIP1
1YFH 3.01 Å, wt Human O6-Alkylguanine-DNA Alkyltransferase Bound To DNA Containing an Alkylated…
9DI0 3.1 Å, Cryo-EM structure of Kif18A bound to a microtubule
9QFE 3.12 Å, Cryo-EM structure of the actin filament hetero-decorated by Coronin-1 and Cofilin-1 on…

Browse structure collections

About this viewer

MolViewer shows 1T38 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.