1TBG: Transducin

Beta-gamma dimer of the heterotrimeric G-protein transducin. Determined by X-ray diffraction at 2.1 Å resolution. Released 1 Apr 1997.

Method: X-ray diffraction
Resolution: 2.1 Å
Organism: Bos taurus
Chains: 8
Atoms: 13,273
Mol. weight: 181.59 kDa
Released: 1 Apr 1997

Explore 1TBG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1TBG contains 36 α-helices and 115 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	4-25	22
α-helix	30-33	4
α-helix	38-39	2
β-strand	47-51	5	1
β-strand	58-63	6	2
β-strand	69-74	6	2
β-strand	78-83	6	2
β-strand	88-94	7	2
β-strand	100-105	6	3
β-strand	111-116	6	3
β-strand	121-125	5	3
β-strand	135-139	5	3
β-strand	146-153	8	4
β-strand	156-161	6	4
β-strand	165-170	6	4
β-strand	175-181	7	4
β-strand	187-192	6	5
β-strand	198-203	6	5
β-strand	207-212	6	5
β-strand	217-222	6	5
β-strand	229-234	6	6
β-strand	240-245	6	6
β-strand	250-254	5	6
β-strand	259-264	6	6
α-helix	272	1
β-strand	273-278	6	7
β-strand	284-289	6	7
β-strand	294-298	5	7
β-strand	304-308	5	7
β-strand	315-320	6	1
β-strand	327-331	5	1
β-strand	336-339	4	1

Chain B: 3 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	4-23	20
α-helix	30-33	4
α-helix	38-39	2
β-strand	47-51	5	8
β-strand	58-63	6	9
β-strand	69-74	6	9
β-strand	78-83	6	9
β-strand	89-94	6	9
β-strand	100-105	6	10
β-strand	111-116	6	10
β-strand	120-125	6	10
β-strand	135-140	6	10
β-strand	146-151	6	11
β-strand	156-161	6	11
β-strand	166-170	5	11
β-strand	175-180	6	11
β-strand	187-192	6	12
β-strand	198-203	6	12
β-strand	208-212	5	12
β-strand	217-222	6	12
β-strand	229-234	6	13
β-strand	240-245	6	13
β-strand	250-254	5	13
β-strand	259-264	6	13
β-strand	273-278	6	14
β-strand	284-289	6	14
β-strand	293-298	6	14
β-strand	303-309	7	14
β-strand	315-320	6	8
β-strand	327-331	5	8
β-strand	336-339	4	8

Chain C: 3 helices, 28 β-strands

Element	Residues	Length	Sheet
α-helix	6-25	20
α-helix	30-33	4
α-helix	38-39	2
β-strand	47-51	5	15
β-strand	58-63	6	16
β-strand	69-74	6	16
β-strand	78-83	6	16
β-strand	89-94	6	16
β-strand	100-105	6	17
β-strand	111-116	6	17
β-strand	121-125	5	17
β-strand	135-139	5	17
β-strand	146-151	6	18
β-strand	156-161	6	18
β-strand	166-170	5	18
β-strand	175-180	6	18
β-strand	187-192	6	19
β-strand	198-203	6	19
β-strand	208-212	5	19
β-strand	217-222	6	19
β-strand	229-234	6	20
β-strand	240-245	6	20
β-strand	250-254	5	20
β-strand	259-264	6	20
β-strand	273-278	6	21
β-strand	284-289	6	21
β-strand	293-298	6	21
β-strand	303-309	7	21
β-strand	315-320	6	15
β-strand	327-331	5	15
β-strand	336-339	4	15

Chain D: 4 helices, 29 β-strands

Element	Residues	Length	Sheet
α-helix	4-25	22
α-helix	30-33	4
α-helix	37-39	3
β-strand	43	1	22
β-strand	47-51	5	23
β-strand	58-63	6	24
β-strand	69-74	6	24
β-strand	78-83	6	24
β-strand	88-94	7	24
β-strand	100-105	6	25
β-strand	111-116	6	25
β-strand	120-125	6	25
β-strand	135-140	6	25
β-strand	146-153	8	26
β-strand	156-161	6	26
β-strand	166-170	5	26
β-strand	175-180	6	26
β-strand	187-192	6	27
β-strand	198-203	6	27
β-strand	208-212	5	27
β-strand	217-222	6	27
β-strand	229-234	6	28
β-strand	240-245	6	28
β-strand	250-254	5	28
β-strand	259-264	6	28
α-helix	272	1
β-strand	273-278	6	22
β-strand	284-289	6	22
β-strand	293-298	6	22
β-strand	304-309	6	22
β-strand	315-320	6	23
β-strand	327-331	5	23
β-strand	336-339	4	23

Chain E: 6 helices, 0 β-strands

Element	Residues	Length
α-helix	503-505	3
α-helix	513-526	14
α-helix	530-532	3
α-helix	533-545	13
α-helix	552-555	4
α-helix	559-561	3

Chain F: 5 helices, 0 β-strands

Element	Residues	Length
α-helix	506-508	3
α-helix	511-526	16
α-helix	530-532	3
α-helix	533-545	13
α-helix	559-561	3

Chain G: 6 helices, 0 β-strands

Element	Residues	Length
α-helix	506-508	3
α-helix	511-525	15
α-helix	530-532	3
α-helix	533-545	13
α-helix	548-550	3
α-helix	552-555	4

Chain H: 5 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	502	1	29
β-strand	504	1	29
α-helix	511-525	15
α-helix	530-532	3
α-helix	533-548	16
α-helix	552-555	4
α-helix	559-561	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Transducin	A, B, C, D	protein	340	Bos taurus	P62871 (AlphaFold model)
Transducin	E, F, G, H	protein	68	Bos taurus	P02698 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>1TBG_1 TRANSDUCIN (chains A, B, C, D)
MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF
TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA
FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL
KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Sequence of entity 2 (E, F, G, H), FASTA

>1TBG_2 TRANSDUCIN (chains E, F, G, H)
APVINIEDLTEKDKLKMEVDQLKKEVTLERMLVSKCCEEFRDYVEERSGEDPLVKGIPED
KNPFKELK

Primary citation

Crystal structure of a G-protein beta gamma dimer at 2.1A resolution. Sondek, J., Bohm, A., Lambright, D.G. et al. Nature (1996) 379:369-374. DOI 10.1038/379369a0 · PubMed

Other PDB entries of the same protein (UniProt P62871 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5KDO 1.9 Å, Heterotrimeric complex of the 4 alanine insertion variant of the Gi alpha1 subunit and…
1GOT 2.0 Å, Heterotrimeric complex of a gt-alpha/gi-alpha chimera and the gt-beta-gamma subunits
3V5W 2.07 Å, Human G Protein-Coupled Receptor Kinase 2 in Complex with Soluble Gbetagamma Subunits…
1GP2 2.3 Å, G protein heterotrimer GI_ALPHA_1 BETA_1 GAMMA_2 with GDP bound
5WG4 2.31 Å, Human GRK2 in complex with Gbetagamma subunits and CCG257284
6B20 2.34 Å, Crystal structure of a complex between G protein beta gamma dimer and an inhibitory…
1GG2 2.4 Å, G protein heterotrimer mutant GI_ALPHA_1(G203A) BETA_1 GAMMA_2 with GDP bound
2TRC 2.4 Å, Phosducin/transducin beta-gamma complex
4MK0 2.4 Å, Crystal structure of G protein-coupled receptor kinase 2 in complex with a a rationally…
6U7C 2.44 Å, Human GRK2 in complex with Gbetagamma subunits and CCG258747
3PVU 2.48 Å, Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD101)
3PVW 2.49 Å, Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor…

Browse structure collections

About this viewer

MolViewer shows 1TBG directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.