1UB6: Antibody 19G2 with sera ligand

Crystal structure of Antibody 19G2 with sera ligand. Determined by X-ray diffraction at 2.12 Å resolution. Released 20 Apr 2004.

Method: X-ray diffraction
Resolution: 2.12 Å
Organism: Mus musculus
Chains: 4
Atoms: 6,784
Mol. weight: 90.31 kDa
Released: 20 Apr 2004

Explore 1UB6 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1UB6 contains 29 α-helices and 92 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 5 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	13
β-strand	10-12	3	14
β-strand	18-25	8	13
α-helix	29-32	3
β-strand	36-41	6	14
β-strand	48-53	6	14
β-strand	59-60	2	14
β-strand	69-74	6	13
β-strand	79-84	6	13
α-helix	89-91	3
β-strand	93-99	7	14
β-strand	105-106	2	14
β-strand	110-114	5	14
α-helix	121-122	2
β-strand	123-127	5	15
β-strand	139-148	10	15
β-strand	154-157	4	16
β-strand	167-168	2	15
α-helix	169-171	3
β-strand	172-174	3	15
β-strand	177-186	10	15
β-strand	196-202	7	16
α-helix	203-205	3
β-strand	207-213	7	16

Chain B: 9 helices, 27 β-strands

Element	Residues	Length	Sheet
β-strand	4-5	2	17
β-strand	9	1	18
α-helix	10-12	3
β-strand	13-14	2	19
β-strand	19-25	7	17
β-strand	30	1	20
β-strand	36	1	20
β-strand	38-43	6	18
β-strand	50-54	5	18
β-strand	58-59	2	18
α-helix	60	1
β-strand	67-71	5	17
β-strand	75-80	6	17
α-helix	85-87	3
β-strand	89-95	7	18
α-helix	101	1
β-strand	102-103	2	18
β-strand	107-109	3	18
α-helix	110	1
β-strand	111-112	2	19
β-strand	116	1	21
β-strand	121-123	3	22
α-helix	124-126	3
α-helix	127-131	5
β-strand	134-144	11	22
β-strand	145	1	21
β-strand	149	1	23
β-strand	152-155	4	24
β-strand	158-159	2	24
β-strand	164-168	5	22
α-helix	169-172	4
β-strand	178-187	10	22
α-helix	188-191	4
β-strand	197-201	5	24
β-strand	203	1	23
β-strand	210-213	4	24

Chain H: 6 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	1
β-strand	10-12	3	2
β-strand	18-25	8	1
α-helix	29-32	3
β-strand	36-41	6	2
β-strand	48-53	6	2
β-strand	59-60	2	2
β-strand	69-74	6	1
β-strand	79-84	6	1
α-helix	89-91	3
β-strand	93-99	7	2
β-strand	105-106	2	2
β-strand	110-114	5	2
α-helix	118-119	2
α-helix	121-122	2
β-strand	123-127	5	3
β-strand	139-148	10	3
β-strand	154-157	4	4
β-strand	167-168	2	3
α-helix	169-171	3
β-strand	172-174	3	3
β-strand	177-186	10	3
β-strand	196-202	7	4
α-helix	203-205	3
β-strand	207-213	7	4

Chain L: 9 helices, 27 β-strands

Element	Residues	Length	Sheet
β-strand	4-5	2	5
β-strand	9	1	6
α-helix	10-12	3
β-strand	13-14	2	7
β-strand	19-25	7	5
β-strand	30	1	8
β-strand	36	1	8
β-strand	38-43	6	6
β-strand	50-54	5	6
β-strand	58-59	2	6
α-helix	60	1
β-strand	67-71	5	5
β-strand	75-80	6	5
α-helix	85-87	3
β-strand	89-95	7	6
α-helix	101	1
β-strand	102-103	2	6
β-strand	107-109	3	6
α-helix	110	1
β-strand	111-112	2	7
β-strand	116	1	9
β-strand	119-123	5	10
α-helix	124-126	3
α-helix	127-131	5
β-strand	134-144	11	10
β-strand	145	1	9
β-strand	149	1	11
β-strand	152-155	4	12
β-strand	158-159	2	12
β-strand	164-168	5	10
α-helix	169-172	4
β-strand	178-187	10	10
α-helix	188-191	4
β-strand	197-201	5	12
β-strand	203	1	11
β-strand	210-213	4	12

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
antibody 19G2, alpha chain	A, H	protein	208	Mus musculus	P01867 (AlphaFold model)
antibody 19G2, beta chain	B, L	protein	213	Mus musculus	P01837 (AlphaFold model)

Sequence of entity 1 (A, H), FASTA

>1UB6_1 antibody 19G2, alpha chain (chains A, H)
AALLESGGGLVKPGGSLKLSCTASGITFSRYIMSWVRQIPEKRLEWVASISSGGITYYPD
SVAGRFTISRDNVRNILYLQMSSLRSEDTALYYCARGQGRPYWGQGTLVTVSAAKTTPPS
VYPAAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGGSSVHTFPALLQSGLYTMSSSVT
VPSSTWPSTVTCSVAHPASGTTVDKKLE

Sequence of entity 2 (B, L), FASTA

>1UB6_2 antibody 19G2, beta chain (chains B, L)
AALTQSPVSNPVTLGTSASISCRSTKSLLHSNGITYLYWYLQKPGQSPQLLIYQMSNLAS
GVPNRFSSSGSGTDFTLRINTVEAEDVGVYYCAQNLELPPTFGAGTKLELKRADAAPTVS
IFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMS
STLTLTKDEYERHNGYTCEATHKTSTSPIVKSF

Primary citation

Structure and Dynamics of Blue Fluorescent Antibody 19G2 at Blue and Violet Fluorescent Temperatures. Beuscher, A.B., Wirsching, P., Lerner, R.A. et al. To be published.

Other PDB entries of the same protein (UniProt P01867 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1YNL 1.7 Å, Identification of Key residues of the NC6.8 Fab antibody fragment binding to synthetic…
1OSP 1.95 Å, Crystal structure of outer surface protein A of borrelia burgdorferi complexed with a…
1NBV 2.0 Å, An autoantibody to single-stranded DNA: comparison of the three-dimensional structures…
1UB5 2.0 Å, Crystal structure of Antibody 19G2 with hapten at 100K
1YNK 2.1 Å, Identification of Key residues of the NC6.8 Fab antibody fragment binding to synthetic…
2RGS 2.13 Å, FC-fragment of monoclonal antibody IGG2B from Mus musculus
2Q8B 2.3 Å, Structure of the malaria antigen AMA1 in complex with a growth-inhibitory antibody
6KRU 2.3 Å, Crystal structure of mouse IgG2b Fc
2Q8A 2.4 Å, Structure of the malaria antigen AMA1 in complex with a growth-inhibitory antibody
1FL3 2.45 Å, Crystal structure of the blue fluorescent antibody (19G2) in complex with stilbene…
1MAM 2.45 Å, Crystal structure to 2.45 a resolution of a monoclonal FAB specific for the brucella a…
2GK0 2.45 Å, Structure of Catalytic Elimination Antibody 13G5 from a twinned crystal in space group C2

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