1UMH: Sugar-recognizing ubiquitin ligase

Name: PDB 1UMH: Structural basis of sugar-recognizing ubiquitin ligase
Published: 2004-04-06
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: ligase

Structural basis of sugar-recognizing ubiquitin ligase. Determined by X-ray diffraction at 2.0 Å resolution. Released 6 Apr 2004.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: Mus musculus
Chains: 1
Atoms: 1,602
Mol. weight: 21.08 kDa
Ligands: NI
Released: 6 Apr 2004

Explore 1UMH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1UMH contains 4 α-helices and 11 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 11 β-strands

Element	Residues	Length	Sheet
α-helix	116-122	7
β-strand	141-144	4	1
β-strand	151-154	4	2
α-helix	157	1
β-strand	171-174	4	2
β-strand	180-187	8	1
α-helix	195-200	6
β-strand	204-212	9	2
β-strand	219-228	10	1
β-strand	234-239	6	1
β-strand	243-244	2	1
α-helix	245-246	2
β-strand	252-258	7	2
β-strand	267-276	10	1
β-strand	287-296	10	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
F-box only protein 2	A	protein	184	Mus musculus	Q80UW2 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1UMH_1 F-box only protein 2 (chains A)
GSHFYFLSKRRRNLLRNPCGEEDLEGWSDVEHGGDGWKVEELPGDNGVEFTQDDSVKKYF
ASSFEWCRKAQVIDLQAEGYWEELLDTTQPAIVVKDWYSGRTDAGSLYELTVRLLSENED
VLAEFATGQVAVPEDGSWMEISHTFIDYGPGVRFVRFEHGGQDSVYWKGWFGARVTNSSV
WVEP

Ligands and cofactors

ID	Name	Formula	Copies
NI	Nickel (II) ion	Ni	1

Primary citation

Structural basis of sugar-recognizing ubiquitin ligase. Mizushima, T., Hirao, T., Yoshida, Y. et al. Nat Struct Mol Biol (2004) 11:365-370. DOI 10.1038/nsmb732 · PubMed

Other PDB entries of the same protein (UniProt Q80UW2 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2RJ2 1.7 Å, Crystal Structure of the Sugar Recognizing SCF Ubiquitin Ligase at 1.7 Resolution
5B4N 2.3 Å, Structure analysis of function associated loop mutant of substrate recognition domain of…
1UMI 2.4 Å, Structural basis of sugar-recognizing ubiquitin ligase
2E31 2.4 Å, Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase
2E33 2.7 Å, Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase
2E32 3.52 Å, Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase

Browse structure collections

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