1W2S: Complement C3 precursor

Solution structure of CR2 SCR 1-2 in its complex with C3d by X-ray scattering. Determined by solution scattering. Released 29 Sept 2005.

Method

Solution scattering

Organism

HOMO SAPIENS

Chains

2

Atoms

449

Mol. weight

49.99 kDa

Released

29 Sept 2005

Explore 1W2S in 3D Show helices and sheets RCSB PDB PDBe

Molecules and chains

>1W2S_1 COMPLEMENT C3 PRECURSOR (chains A)
MLDAERLKHLIVTPSGAGEQNMIGMTPTVIAVHYLDETEQWEKFGLEKRQGALELIKKGY
TQQLAFRQPSSAFAAFVKRAPSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQK
PDGVFQEDAPVIHQEMIGGLRNNNEKDMALTAFVLISLQEAKDICEEQVNSLPGSITKAG
DFLEANYMNLQRSYTVAIAGYALAQMGRLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEAT
SYALLALLQLKDFDFVPPVVRWLNEQRYYGGGYGSTQATFMVFQALAQYQKDAPSDHQEL
NLDVSLQ

>1W2S_2 COMPLEMENT RECEPTOR TYPE 2 PRECURSOR, (chains B)
EAEAISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWD
KPAPKCQYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANN
MWGPTRLPTCVSVFPLEQKLIS

Primary citation

Solution Structure of the Complex between Cr2 Scr 1-2 and C3D of Human Complement: An X-Ray Scattering and Sedimentation Modelling Study. Gilbert, H.E., Eaton, J.T., Hannan, J.P. et al. J Mol Biol (2005) 346:859. DOI 10.1016/J.JMB.2004.12.006 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P01024 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 2WY7 1.7 Å, Staphylococcus aureus complement subversion protein Sbi-IV in complex with complement…
• 2WY8 1.7 Å, Staphylococcus aureus complement subversion protein Sbi-IV in complex with complement…
• 7UE9 1.75 Å, Structure of anti-C3d Fab(3d8b) in complex with C3d
• 1C3D 1.8 Å, X-ray crystal structure of C3D: a C3 fragment and ligand for complement receptor 2
• 6RMT 2.0 Å, Crystal structure of disulphide-linked human C3d dimer
• 7BAG 2.0 Å, C3b in complex with CP40
• 1GHQ 2.04 Å, CR2-C3D complex structure
• 3D5R 2.1 Å, Crystal Structure of Efb-C (N138A) / C3d Complex
• 3OXU 2.1 Å, Complement components factor H CCP19-20 and C3d in complex
• 4I6O 2.14 Å, Crystal structure of chemically synthesized human anaphylatoxin C3a
• 4ONT 2.15 Å, Ternary host recognition complex of complement factor H, C3d, and sialic acid
• 2GOX 2.2 Å, Crystal structure of Efb-C / C3d Complex

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