Structure of B. Anthrax Lethal factor in complex with a hydroxamate inhibitor. Determined by X-ray diffraction at 2.3 Å resolution. Released 31 May 2005.
Explore 1YQY in 3D Show helices and sheets RCSB PDB PDBe
1YQY contains 30 α-helices and 18 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 267-284 | 18 | |
| α-helix | 287-297 | 11 | |
| β-strand | 300 | 1 | 1 |
| α-helix | 301-303 | 3 | |
| α-helix | 304-310 | 7 | |
| α-helix | 313-321 | 9 | |
| α-helix | 324-326 | 3 | |
| α-helix | 332-346 | 15 | |
| α-helix | 351-356 | 6 | |
| α-helix | 370-382 | 13 | |
| β-strand | 386 | 1 | 1 |
| α-helix | 388-395 | 8 | |
| α-helix | 406-422 | 17 | |
| β-strand | 426 | 1 | 2 |
| α-helix | 432-434 | 3 | |
| β-strand | 437-441 | 5 | 3 |
| α-helix | 443-445 | 3 | |
| α-helix | 448-451 | 4 | |
| β-strand | 455 | 1 | 4 |
| β-strand | 463 | 1 | 4 |
| α-helix | 465-473 | 9 | |
| β-strand | 477-480 | 4 | 3 |
| β-strand | 485-487 | 3 | 3 |
| β-strand | 499-504 | 6 | 3 |
| β-strand | 510 | 1 | 2 |
| β-strand | 511-514 | 4 | 3 |
| β-strand | 518-521 | 4 | 3 |
| α-helix | 522 | 1 | |
| β-strand | 525-537 | 13 | 3 |
| β-strand | 540-550 | 11 | 3 |
| α-helix | 552-573 | 22 | |
| β-strand | 583-586 | 4 | 5 |
| α-helix | 592-609 | 18 | |
| α-helix | 612-624 | 13 | |
| β-strand | 629-632 | 4 | 5 |
| α-helix | 636-638 | 3 | |
| α-helix | 640-643 | 4 | |
| α-helix | 649-651 | 3 | |
| β-strand | 657-660 | 4 | 5 |
| α-helix | 661-663 | 3 | |
| β-strand | 665-669 | 5 | 5 |
| α-helix | 680-700 | 21 | |
| α-helix | 708-710 | 3 | |
| α-helix | 712-721 | 10 | |
| α-helix | 728-730 | 3 | |
| α-helix | 733-743 | 11 | |
| α-helix | 749-758 | 10 | |
| α-helix | 760-775 | 16 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Lethal factor | A | protein | 523 | Bacillus anthracis | P15917 (AlphaFold model) |
>1YQY_1 Lethal factor (chains A) GSKDPGMLSRYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKE LLKRIQIDSSDFLSTEEKEFLKKLQIDIRDSLSEEEKELLNRIQVDSSNPLSEKEKEFLK KLKLDIQPYDINQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYL YENMNINNLTATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINERPALDNE RLKWRIQLSPDTRAGYLENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVVPKSKIDT KIQEAQLNINQEWNKALGLPKYTKLITFNVHNRYASNIVESAYLILNEWKNNIQSDLIKK VTNYLVDGNGRFVFTDITLPNIAEQYTHQDEIYEQVHSKGLYVPESRSILLHGPSKGVEL RNDSEGFIHEFGHAVDDYAGYLLDKNQSDLVTNSKKFIDIFKEEGSNLTSYGRTNEAEFF AEAFRLMHSTDHAERLKVQKNAPKTFQFINDQIKFIINSLVPR
| ID | Name | Formula | Copies |
|---|---|---|---|
| 915 | (2R)-2-{[(4-fluoro-3-methylphenyl)sulfonyl]amino}-N-hydroxy-2-tetrahydro-2H-pyr… | C14 H19 F N2 O5 S | 1 |
| ZN | Zinc ion | Zn | 1 |
Anthrax lethal factor inhibition. Shoop, W.L., Xiong, Y., Wiltsie, J. et al. Proc Natl Acad Sci U S A (2005) 102:7958-7963. DOI 10.1073/pnas.0502159102 · PubMed
Other PDB entries of the same protein (UniProt P15917 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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