22BC: PDB entry 22BC

ICA-1103811 bound KCNQ2/3 heteromer with 3:1 stoichiometry, state 3. Determined by electron microscopy at 2.8 Å resolution. Released 3 Jun 2026.

Method
Electron microscopy
Resolution
2.8 Å
Organism
Homo sapiens
Chains
4
Atoms
8,135
Mol. weight
385.75 kDa
Ligands
A1E3Q
Released
3 Jun 2026

Explore 22BC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

22BC contains 53 α-helices and 0 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 14 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix72-8615
α-helix90-923
α-helix93-11422
α-helix116-1183
α-helix119-15032
α-helix157-1637
α-helix167-18317
α-helix196-20914
α-helix213-2153
α-helix218-22710
α-helix229-25426
α-helix264-27512
α-helix288-30518
α-helix307-32721
Chain B: 13 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix73-8614
α-helix90-11021
α-helix116-1183
α-helix119-14830
α-helix152-1543
α-helix156-1649
α-helix167-18216
α-helix196-20914
α-helix216-22712
α-helix229-25426
α-helix264-27512
α-helix288-30518
α-helix307-32721
Chain C: 14 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix71-8616
α-helix90-923
α-helix93-11119
α-helix116-1183
α-helix119-14729
α-helix148-1503
α-helix174-1785
α-helix197-20913
α-helix213-2153
α-helix216-22712
α-helix229-25426
α-helix266-27510
α-helix288-30518
α-helix307-32620
Chain D: 12 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix104-11613
α-helix120-14324
α-helix149-17830
α-helix187-1948
α-helix197-20812
α-helix222-2254
α-helix231-2377
α-helix238-2403
α-helix245-25612
α-helix258-28326
α-helix303-31412
α-helix327-36640

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Potassium voltage-gated channel subfamily KQT member 2A, B, Cprotein872Homo sapiensO43526 (AlphaFold model)
Potassium voltage-gated channel subfamily KQT member 3Dprotein872Homo sapiensO43525 (AlphaFold model)
Sequence of entity 1 (A, B, C), FASTA
>22BC_1 Potassium voltage-gated channel subfamily KQT member 2 (chains A, B, C)
MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG
GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK
SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI
AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF
LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI
GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW
QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSP
CRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV
PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI
RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAIT
DKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFG
AKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQP
QSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGN
LRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESD
TDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK
Sequence of entity 2 (D), FASTA
>22BC_2 Potassium voltage-gated channel subfamily KQT member 3 (chains D)
MGLKARRAAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLALGAG
ADKDGTLLLEGGGRDEGQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRG
WALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLETFAIFIFGAEFALRIWAAGC
CCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATSLRSLRFLQILRMLRM
DRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEF
ETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQ
EQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATWRFYESVVSFPFFRKEQLEAAS
SQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKEPKPVGLNNKERFRTAFRMKA
YAFWQSSEDAGTGDPMAEDRGYGNDFPIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRP
YDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPSTPKHKKSQKGSAFTFPSQQSPR
NEPYVARPSTSEIEDQSMMGKFVKVERQVQDMGKKLDFLVDMHMQHMERLQVQVTEYYPT
KGTSSPAEAEKKEDNRYSDLKTIICNYSETGPPEPPYSFHQVTIDKVSPYGFFAHDPVNL
PRGGPSSGKVQATPPSSATTYVERPTVLPILTLLDSRVSCHSQADLQGPYSDRISPRQRR
SITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYVFGPNGGSSWMREKRYLAEGETDT
DTDPFTPSGSMPLSSTGDGISDSVWTPSNKPI

Ligands and cofactors

IDNameFormulaCopies
A1E3Q4-chloranyl-~{N}-(6-chloranylpyridin-3-yl)benzamideC12 H8 Cl2 N2 O3

Water and common crystallization additives (K) are not listed.

Primary citation

Structural basis for the assembly and modulation of human M-channels. Lu, F., Huang, X., Cai, G. et al. To be published.

Other PDB entries of the same protein (UniProt O43526 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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