22GK: C5a bound C5aR2

C5a bound C5aR2 in complex with beta-arrestin1. Determined by electron microscopy at 2.84 Å resolution. Released 22 Jul 2026.

Method: Electron microscopy
Resolution: 2.84 Å
Organisms: Homo sapiens, Mus musculus, Bos taurus
Chains: 5
Atoms: 6,965
Mol. weight: 131.68 kDa
Released: 22 Jul 2026

Explore 22GK in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

22GK contains 34 α-helices and 54 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 28 β-strands

Element	Residues	Length	Sheet
β-strand	7-8	2	2
β-strand	9-12	4	7
β-strand	18-22	5	7
β-strand	26-28	3	8
β-strand	29-30	2	9
β-strand	33-34	2	9
α-helix	35-36	2
β-strand	37-43	7	7
β-strand	52-62	11	10
α-helix	68-70	3
β-strand	76-87	12	10
α-helix	99-108	10
β-strand	112-117	6	7
α-helix	123-126	4
β-strand	127-129	3	10
α-helix	138-140	3
β-strand	141-151	11	10
α-helix	160-162	3
β-strand	163-168	6	10
β-strand	169-171	3	8
β-strand	183-188	6	11
α-helix	196	1
β-strand	197-203	7	11
β-strand	207-208	2	12
β-strand	214-222	9	11
β-strand	228-241	14	13
β-strand	247-258	12	13
β-strand	262	1	13
β-strand	266-274	9	11
α-helix	279-281	3
β-strand	288-290	3	10
β-strand	300	1	10
α-helix	302-305	4
β-strand	317-320	4	13
β-strand	324-329	6	13
β-strand	342-346	5	13
β-strand	350-351	2	12

Chain C: 4 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	5-11	7
α-helix	18-23	6
α-helix	35-38	4
α-helix	45-64	20
β-strand	67-68	2	1

Chain H: 3 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	6-10	5	3
β-strand	13-14	2	4
β-strand	21-28	8	3
β-strand	35-42	8	4
β-strand	48-55	8	4
β-strand	60-63	4	4
α-helix	68-70	3
β-strand	71-76	6	3
α-helix	77-79	3
β-strand	81-86	6	3
α-helix	91-93	3
β-strand	95-103	9	4
β-strand	112-113	2	4
β-strand	117-120	4	4

Chain L: 3 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	5-8	4	5
β-strand	11-13	3	6
β-strand	20-26	7	5
β-strand	34-39	6	6
β-strand	46-50	5	6
β-strand	54-55	2	6
α-helix	56	1
β-strand	63-68	6	5
β-strand	71-76	6	5
α-helix	81-83	3
β-strand	86-91	6	6
α-helix	97	1
β-strand	98-99	2	6
β-strand	103-106	4	6

Chain R: 15 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	33-35	3
α-helix	38-57	20
α-helix	71-85	15
α-helix	87-95	9
α-helix	104-107	4
α-helix	110-137	28
α-helix	147-149	3
α-helix	152-165	14
α-helix	169-172	4
β-strand	173-179	7	1
β-strand	182-189	8	1
α-helix	195-205	11
α-helix	206-210	5
α-helix	211-226	16
α-helix	232-258	27
α-helix	264-280	17
α-helix	283-294	12
β-strand	327-328	2	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
C5a anaphylatoxin	C	protein	74	Homo sapiens	P01031 (AlphaFold model)
C5a anaphylatoxin chemotactic receptor 2	R	protein	337	Homo sapiens	Q9P296 (AlphaFold model)
Fab30 heavy chain	H	protein	229	Mus musculus
Fab30 light chain	L	protein	215	Mus musculus
Beta-arrestin-1	A	protein	347	Bos taurus	P17870 (AlphaFold model)

Sequence of entity 1 (C), FASTA

>22GK_1 C5a anaphylatoxin (chains C)
TLQKKIEEIAAKYKHSVVKKCCYDGARVNNDETCEQRAARISLGPRCIKAFTECCVVASQ
LRANISHKDMQLGR

Sequence of entity 2 (R), FASTA

>22GK_2 C5a anaphylatoxin chemotactic receptor 2 (chains R)
MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAPLPLYAAIFLVGVPGNAMVAWVA
GKVARRRVGATWLLHLAVADLLCCLSLPILAVPIARGGHWPYGAVGCRALPSIILLTMYA
SVLLLAALSADLCFLALGPAWWSTVQRACGVQVACGAAWTLALLLTVPSAIYRRLHQEHF
PARLQCVVDYGGSSSTENAVTAIRFLFGFLGPLVAVASCHSALLCWAARRCRPLGTAIVV
GFFVCWAPYHLLGLVLTVAAPNSALLARALRAEPLIVGLALAHSCLNPMLFLYFGRAQLR
RSLPAACHWALRESQGQDESVDSKKSTSHDLVSEMEV

Sequence of entity 3 (H), FASTA

>22GK_3 Fab30 heavy chain (chains H)
EISEVQLVESGGGLVQPGGSLRLSCAASGFNVYSSSIHWVRQAPGKGLEWVASISSYYGY
TYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARSRQFWYSGLDYWGQGTLVT
VSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVL
QSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKT

Sequence of entity 4 (L), FASTA

>22GK_4 Fab30 light chain (chains L)
SDIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVP
SRFSGSRSGTDFTLTISSLQPEDFATYYCQQYKYVPVTFGQGTKVEIKRTVAAPSVFIFP
PSDSQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTL
TLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

Sequence of entity 5 (A), FASTA

>22GK_5 Beta-arrestin-1 (chains A)
TRVFKKASPNGKLTVYLGKRDFVDHIDLVEPVDGVVLVDPEYLKERRVYVTLTCAFRYGR
EDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIPPNLPC
SVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIEKVQYAPERPGPQPTAE
TTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFN
TAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTL
LREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLM

Primary citation

Atypical signaling, ligand recognition and selective agonist discovery of complement receptor C5aR2. Qin, J., Cai, C., Shan, M. et al. Cell Res (2026) 36:718-733. DOI 10.1038/s41422-026-01273-1 · PubMed

Other PDB entries of the same protein (UniProt P01031 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9Y6C 2.0 Å, X-ray structure analysis of human Complement Component 5 TE domain in complex with the…
5B71 2.11 Å, Crystal structure of complement C5 in complex with SKY59
4UU9 2.12 Å, Crystal structure of the human c5a in complex with MEDI7814 a neutralising antibody
7AD7 2.3 Å, Crystal structure of human complement C5 in complex with the K8 bovine knob domain…
5B4P 2.4 Å, Complex structure of human C5a and its binding repebody
4P39 2.4 Å, Crystal structure of the human C5aR antagonist C5a-A8
7OP0 2.57 Å, Crystal structure of complement C5 in complex with chemically synthesized K92 knob domain.
3HQA 2.59 Å, Crystal structure of human desarg-C5A
5HCC 2.59 Å, Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Dermacentor…
22GM 2.7 Å, C5a bound C5aR1 in complex with beta-arrestin1
6RPT 2.7 Å, Structure of tick complement inhibitor CirpT1 complexed with macroglobubulin domain 4 of…
7AD6 2.75 Å, Crystal structure of human complement C5 in complex with the K92 bovine knob domain…

Browse structure collections

About this viewer

MolViewer shows 22GK directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.